CA2976383C - Iloperidone for the treatment of schizophrenia - Google Patents

Iloperidone for the treatment of schizophrenia Download PDF

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Publication number
CA2976383C
CA2976383C CA2976383A CA2976383A CA2976383C CA 2976383 C CA2976383 C CA 2976383C CA 2976383 A CA2976383 A CA 2976383A CA 2976383 A CA2976383 A CA 2976383A CA 2976383 C CA2976383 C CA 2976383C
Authority
CA
Canada
Prior art keywords
iloperidone
daily dose
acceptable salt
patients
maintenance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2976383A
Other languages
English (en)
French (fr)
Other versions
CA2976383A1 (en
Inventor
Mihael H. Polymeropoulos
Curt D. Wolfgang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanda Pharmaceuticals Inc
Original Assignee
Vanda Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanda Pharmaceuticals Inc filed Critical Vanda Pharmaceuticals Inc
Publication of CA2976383A1 publication Critical patent/CA2976383A1/en
Application granted granted Critical
Publication of CA2976383C publication Critical patent/CA2976383C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2976383A 2015-02-17 2016-02-17 Iloperidone for the treatment of schizophrenia Active CA2976383C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562117173P 2015-02-17 2015-02-17
US62/117,173 2015-02-17
US201562172436P 2015-06-08 2015-06-08
US62/172,436 2015-06-08
PCT/US2016/018316 WO2016134049A1 (en) 2015-02-17 2016-02-17 Iloperidone for the treatment of schizophrenia

Publications (2)

Publication Number Publication Date
CA2976383A1 CA2976383A1 (en) 2016-08-25
CA2976383C true CA2976383C (en) 2023-05-23

Family

ID=55532275

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2976383A Active CA2976383C (en) 2015-02-17 2016-02-17 Iloperidone for the treatment of schizophrenia

Country Status (9)

Country Link
US (2) US10441580B2 (enExample)
EP (1) EP3258935B1 (enExample)
JP (1) JP6885649B2 (enExample)
KR (1) KR102870956B1 (enExample)
CN (2) CN116211857A (enExample)
BR (1) BR112017017608A2 (enExample)
CA (1) CA2976383C (enExample)
ES (1) ES2870498T3 (enExample)
WO (1) WO2016134049A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11214827B2 (en) * 2018-08-30 2022-01-04 Vanda Pharmaceuticals Inc. Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone
WO2024137439A1 (en) * 2022-12-19 2024-06-27 Vanda Pharmaceuticals Inc. Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia
KR20260019503A (ko) 2023-06-02 2026-02-10 반다 파마슈티칼즈, 인코퍼레이티드. 일로페리돈을 사용한 치료 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2398434T3 (es) 2001-08-31 2013-03-19 Novartis Ag Isómeros ópticos de un metabolito de iloperidona
ES2358416T3 (es) 2001-10-30 2011-05-10 Novartis Ag Formulaciones de liberación prolongada de iloperidona y polímero en forma de estrella.
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
EP1799865B1 (en) * 2004-09-30 2012-06-06 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
US20100063093A1 (en) 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
JP5535914B2 (ja) * 2007-09-10 2014-07-02 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｓｎｐ遺伝子型に基づく抗精神病薬治療
CN101932327A (zh) * 2007-12-19 2010-12-29 詹森药业有限公司 与长效注射用帕潘立酮酯相关的给药方案
JP2012526562A (ja) * 2009-05-15 2012-11-01 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｄｒｄ２又はａｎｋｋ１のｓｎｐ遺伝子型に基づく抗精神病治療
CN104220074A (zh) * 2011-12-02 2014-12-17 大日本住友制药株式会社 鲁拉西酮新给药方案以及其用于治疗、预防和/或控制至少一种cns病症的用途
CA2865845C (en) 2012-03-14 2020-02-18 Vanda Pharmaceuticals Inc. An iloperidone metabolite for use in the treatment of psychiatric disorders
PL2887944T3 (pl) * 2012-08-21 2022-02-21 Sage Therapeutics, Inc. Allopregnanolon do leczenia lekoopornego stanu padaczkowego

Also Published As

Publication number Publication date
EP3258935B1 (en) 2021-04-07
JP2018505901A (ja) 2018-03-01
HK1248551A1 (zh) 2018-10-19
EP3258935A1 (en) 2017-12-27
WO2016134049A1 (en) 2016-08-25
US10441580B2 (en) 2019-10-15
US20180021324A1 (en) 2018-01-25
BR112017017608A2 (en) 2018-05-08
KR102870956B1 (ko) 2025-10-16
ES2870498T3 (es) 2021-10-27
US10987346B2 (en) 2021-04-27
KR20170118830A (ko) 2017-10-25
CN107249586A (zh) 2017-10-13
CA2976383A1 (en) 2016-08-25
JP6885649B2 (ja) 2021-06-16
CN116211857A (zh) 2023-06-06
US20190388412A1 (en) 2019-12-26

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