CA2967826C - A combination of ibudilast and riluzole and methods of using same - Google Patents
A combination of ibudilast and riluzole and methods of using same Download PDFInfo
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- CA2967826C CA2967826C CA2967826A CA2967826A CA2967826C CA 2967826 C CA2967826 C CA 2967826C CA 2967826 A CA2967826 A CA 2967826A CA 2967826 A CA2967826 A CA 2967826A CA 2967826 C CA2967826 C CA 2967826C
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- Canada
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- ibudilast
- riluzole
- disease
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- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
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- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 125000005591 trimellitate group Chemical group 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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- 230000035899 viability Effects 0.000 description 1
- 231100000747 viability assay Toxicity 0.000 description 1
- 238000003026 viability measurement method Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
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- 238000009736 wetting Methods 0.000 description 1
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- 239000011701 zinc Substances 0.000 description 1
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Landscapes
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| PCT/US2015/062456 WO2016085998A1 (en) | 2014-11-26 | 2015-11-24 | Combination of ibudilast and riluzole and methods of using same |
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| CA2967826A1 CA2967826A1 (en) | 2016-06-02 |
| CA2967826C true CA2967826C (en) | 2024-01-16 |
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| JP2021530543A (ja) * | 2018-07-22 | 2021-11-11 | バイオヘイブン・セラピューティクス・リミテッドBiohaven Therapeutics Ltd. | アルツハイマー病を処置するためのリルゾールプロドラッグの使用 |
| MX2021001563A (es) * | 2018-08-16 | 2021-06-15 | Biohaven Therapeutics Ltd | Uso de tabletas de desintegracion oral de riluzol para tratar enfermedades. |
| JP7430719B2 (ja) * | 2018-10-19 | 2024-02-13 | メディシノバ・インコーポレイテッド | イブジラストを用いて眼疾患／障害または損傷を治療する方法 |
| WO2021055890A1 (en) * | 2019-09-20 | 2021-03-25 | Icahn School Of Medicine At Mount Sinai | Controlled release formulations of riluzole and their uses |
| EP4240308A4 (en) * | 2020-10-05 | 2024-10-30 | Icahn School of Medicine at Mount Sinai | Riluzole for the treatment of alzheimer's disease |
| CN117940128A (zh) | 2021-07-26 | 2024-04-26 | 美迪诺亚公司 | 异丁司特用于防止眼癌转移 |
| US12042485B2 (en) | 2021-10-07 | 2024-07-23 | Medicinova, Inc. | Methods of minimizing cancer metastasis |
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| FR2585246A1 (fr) | 1985-07-26 | 1987-01-30 | Cortial | Procede d'obtention de formes pharmaceutiques solides a liberation prolongee |
| US4788055A (en) | 1985-12-09 | 1988-11-29 | Ciba-Geigy Corporation | Resinate sustained release dextromethorphan composition |
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| GB8613688D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
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| US4996047A (en) | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
| CA2002492A1 (en) | 1988-11-11 | 1990-05-11 | Sandra T. A. Malkowska | Pharmaceutical ion exchange resin composition |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| WO2000074676A1 (en) | 1999-06-04 | 2000-12-14 | Vereniging Voor Christelijk Wetenschappelikjk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
| WO2004105756A2 (en) | 2003-05-29 | 2004-12-09 | Novartis Ag | Combination comprising (a) a neuroprotecting agent and (b) an agent binding to gadph and pharmaceutical use thereof |
| AU2005218625A1 (en) * | 2004-03-03 | 2005-09-15 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and riluzole |
| BRPI0518829A2 (pt) | 2004-12-06 | 2008-12-09 | Avigen Inc | mÉtodo para o tratamento de dor neuropÁtica e sÍndromes associadas |
| CA2970273C (en) | 2007-07-11 | 2020-04-14 | Medicinova, Inc. | Treatment of progressive neurodegenerative disease with ibudilast |
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| EP3223815A1 (en) | 2017-10-04 |
| US10258611B2 (en) | 2019-04-16 |
| EP3223815A4 (en) | 2018-06-27 |
| ES2891306T3 (es) | 2022-01-27 |
| BR112017010700A2 (pt) | 2018-05-08 |
| US20170360762A1 (en) | 2017-12-21 |
| JP6827924B2 (ja) | 2021-02-10 |
| CA2967826A1 (en) | 2016-06-02 |
| KR20170086058A (ko) | 2017-07-25 |
| KR102462638B1 (ko) | 2022-11-03 |
| EP3223815B1 (en) | 2021-07-28 |
| US20200030301A1 (en) | 2020-01-30 |
| JP2017535569A (ja) | 2017-11-30 |
| CN107205986A (zh) | 2017-09-26 |
| US11278531B2 (en) | 2022-03-22 |
| US20210000804A1 (en) | 2021-01-07 |
| WO2016085998A1 (en) | 2016-06-02 |
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