CA2964282C - Ripk2 inhibitors and method of treating cancer with same - Google Patents

Ripk2 inhibitors and method of treating cancer with same Download PDF

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Publication number
CA2964282C
CA2964282C CA2964282A CA2964282A CA2964282C CA 2964282 C CA2964282 C CA 2964282C CA 2964282 A CA2964282 A CA 2964282A CA 2964282 A CA2964282 A CA 2964282A CA 2964282 C CA2964282 C CA 2964282C
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CA
Canada
Prior art keywords
optionally substituted
compound
pyrrolo
amine
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2964282A
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English (en)
French (fr)
Other versions
CA2964282A1 (en
Inventor
Mark R. Bray
Richard BROKX
Radoslaw Laufer
Sze-Wan Li
Jacqueline M. Mason
Grace Ng
Heinz W. Pauls
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Health Network
Original Assignee
University Health Network
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Publication date
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Publication of CA2964282A1 publication Critical patent/CA2964282A1/en
Application granted granted Critical
Publication of CA2964282C publication Critical patent/CA2964282C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2964282A 2014-10-27 2015-10-09 Ripk2 inhibitors and method of treating cancer with same Active CA2964282C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462068985P 2014-10-27 2014-10-27
US62/068,985 2014-10-27
PCT/CA2015/051024 WO2016065461A1 (en) 2014-10-27 2015-10-09 Ripk2 inhibitors and method of treating cancer with same

Publications (2)

Publication Number Publication Date
CA2964282A1 CA2964282A1 (en) 2016-05-06
CA2964282C true CA2964282C (en) 2023-03-07

Family

ID=55856305

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2964282A Active CA2964282C (en) 2014-10-27 2015-10-09 Ripk2 inhibitors and method of treating cancer with same

Country Status (6)

Country Link
US (3) US10239881B2 (enExample)
EP (1) EP3212652B1 (enExample)
JP (1) JP6545262B2 (enExample)
CN (1) CN107454899B (enExample)
CA (1) CA2964282C (enExample)
WO (1) WO2016065461A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239881B2 (en) 2014-10-27 2019-03-26 University Health Network RIPK2 inhibitors and method of treating cancer with same
UA123287C2 (uk) * 2016-09-15 2021-03-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Гетероарилкарбоксамідні сполуки як інгібітори ripk2
WO2018052773A1 (en) * 2016-09-15 2018-03-22 Boehringer Ingelheim International Gmbh Pyridine and pyrazine compounds as inhibitors of ripk2
JP6965083B2 (ja) * 2017-10-04 2021-11-10 公益財団法人微生物化学研究会 化合物、及び発光化合物
CN113874015B (zh) * 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN114957280B (zh) * 2021-12-31 2024-09-17 成都赜灵生物医药科技有限公司 噻吩[2,3-d]嘧啶衍生物及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
CA2402516A1 (en) * 2000-03-20 2001-09-27 Roopa Rai Non-amidine containing protease inhibitors
EP1182263A1 (en) 2000-08-11 2002-02-27 Evotec OAI AG Process for detecting threonine/serine kinase activity
US6426221B1 (en) 2001-08-01 2002-07-30 Isis Pharmaceuticals, Inc. Antisense modulation of RIP2 expression
WO2003042369A2 (en) 2001-11-13 2003-05-22 Phylos, Inc. Cellular kinase targets and inhibitors, and methods for their use
AU2008323628B2 (en) 2007-11-15 2013-10-17 Ym Biosciences Australia Pty Ltd N-containing heterocyclic compounds
US20110218211A1 (en) 2008-08-16 2011-09-08 Genentech, Inc. Azaindole inhibitors of iap
WO2010046215A2 (en) 2008-10-21 2010-04-29 Syngenta Participations Ag Diaza-indole derivatives and their use as fungicides
US20110207736A1 (en) * 2009-12-23 2011-08-25 Gatekeeper Pharmaceuticals, Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
WO2011140442A1 (en) 2010-05-07 2011-11-10 Glaxo Group Limited Amino-quinolines as kinase inhibitors
US8889684B2 (en) * 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
SG192769A1 (en) * 2011-03-04 2013-09-30 Glaxosmithkline Ip No 2 Ltd Amino-quinolines as kinase inhibitors
WO2013078254A1 (en) 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors
US10239881B2 (en) 2014-10-27 2019-03-26 University Health Network RIPK2 inhibitors and method of treating cancer with same

Also Published As

Publication number Publication date
US10875863B2 (en) 2020-12-29
EP3212652A1 (en) 2017-09-06
JP2017531686A (ja) 2017-10-26
US20180282335A1 (en) 2018-10-04
CN107454899B (zh) 2020-05-29
EP3212652A4 (en) 2018-04-25
US10239881B2 (en) 2019-03-26
CA2964282A1 (en) 2016-05-06
US20190225617A1 (en) 2019-07-25
US20210261554A1 (en) 2021-08-26
WO2016065461A1 (en) 2016-05-06
JP6545262B2 (ja) 2019-07-17
CN107454899A (zh) 2017-12-08
HK1243407A1 (zh) 2018-07-13
EP3212652B1 (en) 2021-02-17

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