CA2957868C - Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative - Google Patents
Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative Download PDFInfo
- Publication number
- CA2957868C CA2957868C CA2957868A CA2957868A CA2957868C CA 2957868 C CA2957868 C CA 2957868C CA 2957868 A CA2957868 A CA 2957868A CA 2957868 A CA2957868 A CA 2957868A CA 2957868 C CA2957868 C CA 2957868C
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- Prior art keywords
- compound
- rsv
- formula
- salt
- pharmaceutical composition
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188494 | 2014-10-10 | ||
| EP14188494.0 | 2014-10-10 | ||
| PCT/GB2015/052944 WO2016055791A1 (en) | 2014-10-10 | 2015-10-08 | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2957868A1 CA2957868A1 (en) | 2016-04-14 |
| CA2957868C true CA2957868C (en) | 2023-02-28 |
Family
ID=51842340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2957868A Active CA2957868C (en) | 2014-10-10 | 2015-10-08 | Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9732098B2 (show.php) |
| EP (2) | EP3204389B1 (show.php) |
| JP (2) | JP2017531039A (show.php) |
| KR (1) | KR20170058921A (show.php) |
| CN (1) | CN106852144B (show.php) |
| AU (1) | AU2015329789B2 (show.php) |
| BR (1) | BR112017005104B1 (show.php) |
| CA (1) | CA2957868C (show.php) |
| EA (1) | EA201790796A8 (show.php) |
| IL (1) | IL250823A0 (show.php) |
| MX (1) | MX2017004652A (show.php) |
| SG (1) | SG11201701184WA (show.php) |
| WO (2) | WO2016055791A1 (show.php) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204389B1 (en) | 2014-10-10 | 2019-06-26 | Pulmocide Limited | Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative |
| JP6694886B2 (ja) | 2014-12-18 | 2020-05-20 | プルモシデ リミテド | ４，５−ジヒドロ−６Ｈ−チエノ［３，２−ｄ］ベンゾアゼピン誘導体及び呼吸器合胞体ウイルス（ＲＳＶ）感染を治療するためのその使用 |
| MY197231A (en) | 2015-07-22 | 2023-06-06 | Enanta Pharm Inc | Benzodiazepine derivatives as rsv inhibitors |
| US20170226129A1 (en) | 2016-01-15 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| ES2877808T3 (es) * | 2016-02-03 | 2021-11-17 | Janssen Sciences Ireland Unlimited Co | Producto combinado para tratar o mejorar una infección por virus respiratorio sincicial |
| WO2017175000A1 (en) | 2016-04-08 | 2017-10-12 | Pulmocide Limited | Compounds |
| US10398706B2 (en) | 2017-01-06 | 2019-09-03 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as RSV inhibitors |
| NZ756805A (en) | 2017-02-16 | 2025-10-31 | Enanta Pharm Inc | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| WO2019006291A1 (en) * | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| BR112020006334A2 (pt) | 2017-09-29 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | combinação de agentes farmacêuticos como inibidores de rsv |
| EP3710009B1 (en) | 2017-11-13 | 2025-07-30 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| WO2019199908A1 (en) * | 2018-04-11 | 2019-10-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| WO2020190935A1 (en) | 2019-03-18 | 2020-09-24 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as rsv inhibitors |
| WO2020210246A1 (en) * | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| JP7681009B2 (ja) | 2019-10-04 | 2025-05-21 | エナンタ ファーマシューティカルズ インコーポレイテッド | 抗ウイルス性複素環化合物 |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2022010882A1 (en) * | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CA3173354A1 (en) | 2021-02-26 | 2022-09-01 | Adam SZYMANIAK | A 2,3-dihydrofuro[2,3-c]pyridine-3-carboxamide compound and its antiviral use |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693635A (en) | 1993-07-29 | 1997-12-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| PL351470A1 (en) | 1999-04-28 | 2003-04-22 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| EP2240029A4 (en) * | 2008-01-07 | 2012-08-22 | Synta Pharmaceuticals Corp | COMPOUNDS FOR USE AGAINST INFLAMMATORY AND IMMUNOMIC DISEASES |
| US8999969B2 (en) | 2009-07-09 | 2015-04-07 | Gilead Sciences, Inc. | Anti-RSV compounds |
| KR101804588B1 (ko) | 2009-10-13 | 2017-12-04 | 리간드 파마슈티칼스 인코포레이티드 | 조혈 성장 인자 모방체 소분자 화합물 및 이의 용도 |
| US8791136B2 (en) | 2010-07-29 | 2014-07-29 | Rigel Pharmaceuticals, Inc. | Substituted pyridine, pyridazine, pyrazine and pyrimidine compounds and methods for using the same |
| WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| RU2017106742A (ru) | 2014-08-05 | 2018-09-06 | Элиос Биофарма, Инк. | Комбинированная терапия для лечения парамиксовируса |
| EP3204389B1 (en) * | 2014-10-10 | 2019-06-26 | Pulmocide Limited | Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative |
| US20170226129A1 (en) | 2016-01-15 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| ES2877808T3 (es) | 2016-02-03 | 2021-11-17 | Janssen Sciences Ireland Unlimited Co | Producto combinado para tratar o mejorar una infección por virus respiratorio sincicial |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
-
2015
- 2015-10-08 EP EP15784440.8A patent/EP3204389B1/en active Active
- 2015-10-08 KR KR1020177006394A patent/KR20170058921A/ko not_active Withdrawn
- 2015-10-08 MX MX2017004652A patent/MX2017004652A/es unknown
- 2015-10-08 WO PCT/GB2015/052944 patent/WO2016055791A1/en not_active Ceased
- 2015-10-08 US US15/305,003 patent/US9732098B2/en active Active
- 2015-10-08 US US15/516,809 patent/US10189863B2/en active Active
- 2015-10-08 WO PCT/GB2015/052945 patent/WO2016055792A1/en not_active Ceased
- 2015-10-08 SG SG11201701184WA patent/SG11201701184WA/en unknown
- 2015-10-08 CA CA2957868A patent/CA2957868C/en active Active
- 2015-10-08 AU AU2015329789A patent/AU2015329789B2/en active Active
- 2015-10-08 EA EA201790796A patent/EA201790796A8/ru unknown
- 2015-10-08 JP JP2017538467A patent/JP2017531039A/ja not_active Withdrawn
- 2015-10-08 BR BR112017005104-4A patent/BR112017005104B1/pt active IP Right Grant
- 2015-10-08 JP JP2017538466A patent/JP6675407B2/ja active Active
- 2015-10-08 EP EP15782045.7A patent/EP3204388B1/en active Active
- 2015-10-08 CN CN201580054496.3A patent/CN106852144B/zh active Active
-
2017
- 2017-02-27 IL IL250823A patent/IL250823A0/en active IP Right Grant
- 2017-07-06 US US15/642,637 patent/US9926335B2/en active Active
-
2018
- 2018-02-22 US US15/902,077 patent/US10035810B2/en active Active
- 2018-07-12 US US16/033,464 patent/US10273249B2/en active Active
-
2019
- 2019-03-11 US US16/298,460 patent/US10472375B2/en active Active
Also Published As
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| CA2957868C (en) | Novel 5,6-dihydro-4h-benzo[b]thieno-[2,3-d]azepine derivative | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200908 |
|
| EEER | Examination request |
Effective date: 20200908 |
|
| EEER | Examination request |
Effective date: 20200908 |
|
| EEER | Examination request |
Effective date: 20200908 |
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| EEER | Examination request |
Effective date: 20200908 |