CA2956550A1 - Bruton's tyrosine kinase inhibitor combinations and uses thereof - Google Patents
Bruton's tyrosine kinase inhibitor combinations and uses thereof Download PDFInfo
- Publication number
- CA2956550A1 CA2956550A1 CA2956550A CA2956550A CA2956550A1 CA 2956550 A1 CA2956550 A1 CA 2956550A1 CA 2956550 A CA2956550 A CA 2956550A CA 2956550 A CA2956550 A CA 2956550A CA 2956550 A1 CA2956550 A1 CA 2956550A1
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- Prior art keywords
- inhibitor
- anticancer agent
- cell
- lymphoma
- mcl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K38/19—Cytokines; Lymphokines; Interferons
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
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- Zoology (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US201462034997P | 2014-08-08 | 2014-08-08 | |
| US62/034,997 | 2014-08-08 | ||
| US201462082972P | 2014-11-21 | 2014-11-21 | |
| US62/082,972 | 2014-11-21 | ||
| US201462086162P | 2014-12-01 | 2014-12-01 | |
| US62/086,162 | 2014-12-01 | ||
| US201562196251P | 2015-07-23 | 2015-07-23 | |
| US62/196,251 | 2015-07-23 | ||
| PCT/US2015/044095 WO2016022853A1 (en) | 2014-08-08 | 2015-08-06 | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
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| TW (1) | TWI586354B (OSRAM) |
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| EA201890869A3 (ru) | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| LT3179991T (lt) | 2014-08-11 | 2021-11-10 | Acerta Pharma B.V. | Terapiniai btk inhibitoriaus ir bcl-2 inhibitoriaus deriniai |
| WO2016071770A2 (en) * | 2014-11-05 | 2016-05-12 | Janssen Pharmaceutica Nv | Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same |
| MX2018014577A (es) | 2016-05-27 | 2019-05-20 | Tg Therapeutics Inc | Combinacion de anticuerpo anti-cd20, inhibidor selectivo de quinasa p13-delta, e inhibidor de btk para tratar trastornos proliferativos de celulas b. |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| AU2018251898A1 (en) | 2017-04-13 | 2019-10-31 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| RS65207B1 (sr) | 2017-07-14 | 2024-03-29 | Janssen Pharmaceutica Nv | Formulacije bedakvilina sa dugim delovanjem |
| WO2019070777A2 (en) * | 2017-10-04 | 2019-04-11 | University Of Maryland, Baltimore County | PIM KINASE INHIBITORS IN COMBINATION WITH AUTOPHAGIA INHIBITORS FOR THE TREATMENT OF CANCERS |
| TW202014184A (zh) * | 2018-04-30 | 2020-04-16 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之組合 |
| EP3787751A1 (en) | 2018-05-03 | 2021-03-10 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| CN111053777A (zh) * | 2018-10-16 | 2020-04-24 | 正大天晴药业集团股份有限公司 | 伊布替尼的药物组合物及其应用 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EA202191903A1 (ru) * | 2019-01-09 | 2021-11-12 | Селджин Корпорейшн | Антипролиферативные соединения и вторые активные агенты для комбинированного применения |
| ES2966132T3 (es) | 2019-02-22 | 2024-04-18 | Janssen Pharmaceutica Nv | Forma cristalina de monohidrato de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifluorometil)-(2-(trifluorometil)piridin-4-il)- 1h-pirazol-4-carboxamida |
| BR112021019799A2 (pt) | 2019-04-11 | 2021-12-07 | Janssen Pharmaceutica Nv | Derivados contendo anéis de piridina como inibidores de malt1 |
| EP3871665B1 (en) | 2020-02-28 | 2025-12-24 | Martin-Luther-Universität Halle-Wittenberg | Inhibitors of rna-binding proteins as anti-cancer drugs |
| WO2021176098A1 (en) * | 2020-03-05 | 2021-09-10 | Université de Lausanne | Modulators of aralar for treating neurological disorders |
| WO2022008643A1 (en) * | 2020-07-09 | 2022-01-13 | Janssen Pharmaceutica Nv | Long-acting formulations |
| WO2022038252A1 (en) * | 2020-08-21 | 2022-02-24 | Janssen Pharmaceutica Nv | Amorphous form of a malt1 inhibitor and formulations thereof |
| EP3967307A1 (en) * | 2020-09-15 | 2022-03-16 | Instytut Hematologii I Transfuzologii | Use of pim kinase inhibitors to augment the efficacy of anti-cd20 antibody-based therapies in hematologic malignancies and non-malignant conditions |
| CN114469949A (zh) * | 2020-10-27 | 2022-05-13 | 正大天晴药业集团股份有限公司 | 用于治疗弥漫大b细胞淋巴瘤的喹啉衍生物 |
| EP4301365A1 (en) * | 2021-03-03 | 2024-01-10 | Janssen Pharmaceutica NV | Combination therapy using a malt1 inhibitor and a btk inhibitor |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| WO2025002340A1 (zh) * | 2023-06-29 | 2025-01-02 | 上海翰森生物医药科技有限公司 | 三并环类抑制剂与抗癌剂在制备抗肿瘤药物中的联合应用 |
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| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| US7832117B2 (en) * | 2006-07-17 | 2010-11-16 | Nike, Inc. | Article of footwear including full length composite plate |
| PT2201840E (pt) | 2006-09-22 | 2012-02-14 | Pharmacyclics Inc | Inibidores da tirosina quinase de bruton |
| ES2547229T3 (es) | 2007-08-07 | 2015-10-02 | Purdue Research Foundation | Inhibidores de cinasa y usos de los mismos |
| EA201890869A3 (ru) | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| KR102054468B1 (ko) * | 2011-10-19 | 2019-12-11 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(btk)의 억제제의 용도 |
| CA3218491A1 (en) * | 2012-06-04 | 2013-12-12 | Pharmacyclics Llc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
| JP6280546B2 (ja) * | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
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- 2015-08-06 BR BR112017002232A patent/BR112017002232A2/pt not_active Application Discontinuation
- 2015-08-07 TW TW104125847A patent/TWI586354B/zh not_active IP Right Cessation
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2016022853A1 (en) | 2016-02-11 |
| US9730938B2 (en) | 2017-08-15 |
| MX2017001656A (es) | 2017-07-24 |
| US20160038495A1 (en) | 2016-02-11 |
| TWI586354B (zh) | 2017-06-11 |
| EP3177366A4 (en) | 2018-04-04 |
| JP2017523207A (ja) | 2017-08-17 |
| CN106714909A (zh) | 2017-05-24 |
| BR112017002232A2 (pt) | 2018-07-24 |
| TW201609107A (zh) | 2016-03-16 |
| US20180071295A1 (en) | 2018-03-15 |
| EP3177366A1 (en) | 2017-06-14 |
| AU2015300966A1 (en) | 2017-02-16 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20200831 |