CA2955265A1 - Method for inhibiting intracellular activated ras using intact immunoglobulin-type antibody having cytosol-penatrating ability and use thereof - Google Patents
Method for inhibiting intracellular activated ras using intact immunoglobulin-type antibody having cytosol-penatrating ability and use thereof Download PDFInfo
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- CA2955265A1 CA2955265A1 CA2955265A CA2955265A CA2955265A1 CA 2955265 A1 CA2955265 A1 CA 2955265A1 CA 2955265 A CA2955265 A CA 2955265A CA 2955265 A CA2955265 A CA 2955265A CA 2955265 A1 CA2955265 A1 CA 2955265A1
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140092687 | 2014-07-22 | ||
| KR10-2014-0092687 | 2014-07-22 | ||
| KR10-2015-0103214 | 2015-07-21 | ||
| KR1020150103214A KR101602876B1 (ko) | 2014-07-22 | 2015-07-21 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| PCT/KR2015/007627 WO2016013871A1 (ko) | 2014-07-22 | 2015-07-22 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2955265A1 true CA2955265A1 (en) | 2016-01-28 |
Family
ID=55354089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2955265A Abandoned CA2955265A1 (en) | 2014-07-22 | 2015-07-22 | Method for inhibiting intracellular activated ras using intact immunoglobulin-type antibody having cytosol-penatrating ability and use thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10851177B2 (enExample) |
| EP (1) | EP3173099B1 (enExample) |
| JP (1) | JP6798988B2 (enExample) |
| KR (2) | KR101602876B1 (enExample) |
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| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| CA3025757A1 (en) | 2016-05-27 | 2017-11-30 | Orum Therapeutics Inc. | Cytosol-penetrating antibody and use thereof |
| EP3712180A4 (en) * | 2017-11-16 | 2021-08-11 | Orum Therapeutics Inc. | RAS INHIBITOR ANTIBODIES ACTIVATED IN A CELL BY INTERNALIZATION IN CYTOSOL OF THE CELL, AND ITS USE |
| US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
| JP2021532135A (ja) * | 2018-07-23 | 2021-11-25 | 中外製薬株式会社 | 標的細胞特異的な細胞質侵入抗原結合分子 |
| KR20200088780A (ko) * | 2019-01-15 | 2020-07-23 | 오름테라퓨틱 주식회사 | 세포질 침투성이 증진된 항체 |
| US20220177603A1 (en) * | 2019-05-01 | 2022-06-09 | Universidade De Santiago De Compostela | Intracellular delivery of anti-kras antibodies formulated into nanocapsules |
| TW202204420A (zh) * | 2020-04-30 | 2022-02-01 | 美商建南德克公司 | Ｋｒａｓ特異性抗體及其用途 |
| IL307396A (en) * | 2021-04-02 | 2023-12-01 | Massachusetts Gen Hospital | Methods for inhibiting RAS |
| CN117916258A (zh) | 2021-07-20 | 2024-04-19 | 亚洲大学校产学协力团 | 穿透进细胞以降解和去除靶蛋白的细胞穿透降解抗体及其用途 |
| US20250122308A1 (en) * | 2021-09-17 | 2025-04-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Targeting mutant kras with a mutation specific iga |
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| FR2706486B1 (fr) | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
| CN1241574A (zh) | 1998-07-02 | 2000-01-19 | 中国人民解放军第四军医大学 | 抗肝癌单克隆抗体HAb25及其单链抗体和双功能抗体 |
| AU2003219277A1 (en) * | 2002-03-14 | 2003-09-29 | Medical Research Council | Intracellular antibodies |
| GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
| WO2004046188A2 (en) | 2002-11-15 | 2004-06-03 | Medical Research Council | Anti-activated ras antibodies |
| KR20090008290A (ko) * | 2006-03-27 | 2009-01-21 | 글로브이뮨 | Ｒａｓ 돌연변이와 그에 관련된 조성물 및 방법 |
| MX2010007357A (es) | 2008-01-03 | 2011-03-03 | The Scripps Res Institute Star | Puesta de anti-cuerpos en objetivo mediante un dominio de reconocimiento modular. |
| KR100849941B1 (ko) * | 2008-04-29 | 2008-08-01 | 원우이에프엔지니어링주식회사 | 열 및 연기 화재감지장치 복합시험기 |
| US20110159569A1 (en) * | 2008-04-30 | 2011-06-30 | Ajou University IndustryAcademic Cooperation Found | Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same |
| KR101075123B1 (ko) * | 2008-10-24 | 2011-10-19 | 아주대학교산학협력단 | 핵산가수분해 능 및 암세포내 침투능력을 갖는 인간화된 항체 및 그 용도 |
| CN102209726A (zh) | 2008-11-11 | 2011-10-05 | 亚州大学校产学协力团 | 具有细胞穿透性、序列特异性和核酸水解性的抗体、其制备方法及包含所述抗体的药物组合物 |
| CN101402675B (zh) | 2008-11-28 | 2012-05-30 | 中国人民解放军第三军医大学第三附属医院 | 一种靶向抑制ανβ3阳性细胞增殖的环肽 |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| GB201103631D0 (en) * | 2011-03-03 | 2011-04-13 | Univ Leeds | Identification of candidate therapeutics |
| WO2012135831A1 (en) | 2011-04-01 | 2012-10-04 | Yale University | Cell-penetrating anti-dna antibodies and uses thereof inhibit dna repair |
| US9283272B2 (en) | 2012-03-30 | 2016-03-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
| WO2014042209A1 (ja) | 2012-09-14 | 2014-03-20 | 公益財団法人がん研究会 | ＥｐＣＡＭに結合するペプチド |
| US10011635B2 (en) | 2013-09-27 | 2018-07-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
| WO2016013870A1 (ko) | 2014-07-22 | 2016-01-28 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| EP3277314A4 (en) | 2015-04-03 | 2018-08-29 | Eureka Therapeutics, Inc. | Constructs targeting afp peptide/mhc complexes and uses thereof |
| KR101790669B1 (ko) | 2015-10-14 | 2017-10-26 | 아주대학교산학협력단 | 개선된 분할 녹색 형광 단백질 상보 시스템 및 이의 용도 |
| CA3025757A1 (en) | 2016-05-27 | 2017-11-30 | Orum Therapeutics Inc. | Cytosol-penetrating antibody and use thereof |
| KR101836392B1 (ko) | 2016-08-17 | 2018-03-08 | 한림대학교 산학협력단 | 사이클릭 펩타이드를 포함하는 백신 조성물, 사이클릭 펩타이드에 대한 항체 또는 이를 포함하는 항암 조성물 |
| EP3712180A4 (en) | 2017-11-16 | 2021-08-11 | Orum Therapeutics Inc. | RAS INHIBITOR ANTIBODIES ACTIVATED IN A CELL BY INTERNALIZATION IN CYTOSOL OF THE CELL, AND ITS USE |
| US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
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2015
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- 2015-07-22 JP JP2017525496A patent/JP6798988B2/ja not_active Expired - Fee Related
- 2015-07-22 BR BR112017001306-1A patent/BR112017001306A2/pt not_active Application Discontinuation
- 2015-07-22 EP EP15825508.3A patent/EP3173099B1/en active Active
- 2015-07-22 MX MX2017001012A patent/MX2017001012A/es unknown
- 2015-07-22 RU RU2017103679A patent/RU2017103679A/ru not_active Application Discontinuation
- 2015-07-22 AU AU2015292956A patent/AU2015292956B2/en not_active Ceased
- 2015-07-22 CN CN201580045140.3A patent/CN106999575A/zh active Pending
- 2015-07-22 CA CA2955265A patent/CA2955265A1/en not_active Abandoned
- 2015-07-22 US US15/327,539 patent/US10851177B2/en not_active Expired - Fee Related
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| US10851177B2 (en) | 2020-12-01 |
| RU2017103679A (ru) | 2018-08-06 |
| KR20160033670A (ko) | 2016-03-28 |
| AU2015292956A1 (en) | 2017-02-09 |
| AU2015292956B2 (en) | 2020-04-02 |
| MX2017001012A (es) | 2018-06-19 |
| KR101732553B1 (ko) | 2017-05-08 |
| BR112017001306A2 (pt) | 2018-01-30 |
| KR20160011599A (ko) | 2016-02-01 |
| IL250137A0 (en) | 2017-03-30 |
| US20170158777A1 (en) | 2017-06-08 |
| JP2017529870A (ja) | 2017-10-12 |
| KR101602876B1 (ko) | 2016-03-11 |
| EP3173099B1 (en) | 2020-03-04 |
| EP3173099A1 (en) | 2017-05-31 |
| JP6798988B2 (ja) | 2020-12-09 |
| EP3173099A4 (en) | 2018-03-14 |
| IL250137B (en) | 2020-05-31 |
| CN106999575A (zh) | 2017-08-01 |
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