CA2954780A1 - Neutralizing anti-influenza b antibodies and uses thereof - Google Patents

Neutralizing anti-influenza b antibodies and uses thereof Download PDF

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Publication number
CA2954780A1
CA2954780A1 CA2954780A CA2954780A CA2954780A1 CA 2954780 A1 CA2954780 A1 CA 2954780A1 CA 2954780 A CA2954780 A CA 2954780A CA 2954780 A CA2954780 A CA 2954780A CA 2954780 A1 CA2954780 A1 CA 2954780A1
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CA
Canada
Prior art keywords
seq
antibody
influenza
lcdr
hcdr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2954780A
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English (en)
French (fr)
Inventor
Davide Corti
Antonio Lanzavecchia
Nicole KALLEWAARD-LELAY
Qing Zhu
Ebony BENJAMIN
Leslie WACHTER
Andy Yuan
Josephine Mary MCAULIFFE
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Humabs Biomed SA
MedImmune LLC
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MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of CA2954780A1 publication Critical patent/CA2954780A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2954780A 2014-07-15 2015-07-14 Neutralizing anti-influenza b antibodies and uses thereof Pending CA2954780A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024804P 2014-07-15 2014-07-15
US62/024,804 2014-07-15
PCT/US2015/040385 WO2016011035A2 (en) 2014-07-15 2015-07-14 Neutralizing anti-influenza b antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CA2954780A1 true CA2954780A1 (en) 2016-01-21

Family

ID=55079157

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2954780A Pending CA2954780A1 (en) 2014-07-15 2015-07-14 Neutralizing anti-influenza b antibodies and uses thereof

Country Status (10)

Country Link
US (6) US10294292B2 (enExample)
EP (1) EP3169407B1 (enExample)
JP (4) JP6837434B2 (enExample)
CN (4) CN113563462B (enExample)
AU (3) AU2015289805B2 (enExample)
BR (1) BR112017000640A2 (enExample)
CA (1) CA2954780A1 (enExample)
MX (3) MX392761B (enExample)
RU (2) RU2711932C2 (enExample)
WO (1) WO2016011035A2 (enExample)

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CN112048006B (zh) * 2020-09-08 2021-04-27 扬州大学 一种替代中和效力测定的elisa方法及其应用
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JP2023052268A (ja) 2023-04-11
US20220025020A1 (en) 2022-01-27
RU2017104638A (ru) 2018-08-15
RU2739952C2 (ru) 2020-12-30
MX2022006561A (es) 2022-07-11
EP3169407A4 (en) 2018-04-25
US11174304B2 (en) 2021-11-16
RU2711932C2 (ru) 2020-01-23
JP2024069341A (ja) 2024-05-21
JP7209754B2 (ja) 2023-01-20
US12325740B2 (en) 2025-06-10
CN106573154A (zh) 2017-04-19
US20190233504A1 (en) 2019-08-01
AU2024202231A1 (en) 2024-05-02
CN113173990B (zh) 2024-10-29
US20240076357A1 (en) 2024-03-07
JP7453430B2 (ja) 2024-03-19
US10294292B2 (en) 2019-05-21
CN113173990A (zh) 2021-07-27
AU2015289805A1 (en) 2017-03-02
US20200190169A1 (en) 2020-06-18
RU2020100073A (ru) 2020-03-03
AU2015289805B2 (en) 2020-06-25
EP3169407B1 (en) 2026-02-11
MX2017000595A (es) 2017-10-12
US20250263470A1 (en) 2025-08-21
CN113563462B (zh) 2024-08-13
JP2017523805A (ja) 2017-08-24
WO2016011035A3 (en) 2016-03-10
US10519221B2 (en) 2019-12-31
CN113563462A (zh) 2021-10-29
CN119161468A (zh) 2024-12-20
JP6837434B2 (ja) 2021-03-03
CN106573154B (zh) 2021-06-15
AU2020233635B2 (en) 2024-01-18
BR112017000640A2 (pt) 2017-11-14
US20170218054A1 (en) 2017-08-03
AU2020233635A1 (en) 2020-10-08
MX392761B (es) 2025-03-21
US11787853B2 (en) 2023-10-17
RU2017104638A3 (enExample) 2019-07-17
JP2021074013A (ja) 2021-05-20
EP3169407A2 (en) 2017-05-24
WO2016011035A8 (en) 2016-12-08
MX2022006558A (es) 2022-07-11
WO2016011035A2 (en) 2016-01-21
RU2020100073A3 (enExample) 2020-06-10

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