CA2953159A1 - Inhibiteurs de matriptase et utilisations associees - Google Patents

Inhibiteurs de matriptase et utilisations associees Download PDF

Info

Publication number
CA2953159A1
CA2953159A1 CA2953159A CA2953159A CA2953159A1 CA 2953159 A1 CA2953159 A1 CA 2953159A1 CA 2953159 A CA2953159 A CA 2953159A CA 2953159 A CA2953159 A CA 2953159A CA 2953159 A1 CA2953159 A1 CA 2953159A1
Authority
CA
Canada
Prior art keywords
disorders
compound
treatment
prevention
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2953159A
Other languages
English (en)
Inventor
Pierre-Luc Boudreault
Eloic Colombo
Martin Richter
Richard Leduc
Eric Marsault
Baptiste Plancq
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neomed Institute
Original Assignee
Neomed Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neomed Institute filed Critical Neomed Institute
Priority to CA2953168A priority Critical patent/CA2953168A1/fr
Priority to CA2953159A priority patent/CA2953159A1/fr
Priority to CA2953166A priority patent/CA2953166A1/fr
Priority to CA3085853A priority patent/CA3085853A1/fr
Priority to PCT/CA2017/051575 priority patent/WO2018112648A1/fr
Priority to US16/471,979 priority patent/US10988505B2/en
Publication of CA2953159A1 publication Critical patent/CA2953159A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2953159A 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees Abandoned CA2953159A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2953168A CA2953168A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953159A CA2953159A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953166A CA2953166A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA3085853A CA3085853A1 (fr) 2016-12-23 2017-12-21 Inhibiteurs de la matriptase et leurs utilisations
PCT/CA2017/051575 WO2018112648A1 (fr) 2016-12-23 2017-12-21 Inhibiteurs de la matriptase et leurs utilisations
US16/471,979 US10988505B2 (en) 2016-12-23 2017-12-21 Matriptase inhibitors and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2953168A CA2953168A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953159A CA2953159A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953166A CA2953166A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees

Publications (1)

Publication Number Publication Date
CA2953159A1 true CA2953159A1 (fr) 2018-06-23

Family

ID=62624057

Family Applications (4)

Application Number Title Priority Date Filing Date
CA2953168A Abandoned CA2953168A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953166A Abandoned CA2953166A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953159A Abandoned CA2953159A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA3085853A Pending CA3085853A1 (fr) 2016-12-23 2017-12-21 Inhibiteurs de la matriptase et leurs utilisations

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA2953168A Abandoned CA2953168A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees
CA2953166A Abandoned CA2953166A1 (fr) 2016-12-23 2016-12-23 Inhibiteurs de matriptase et utilisations associees

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3085853A Pending CA3085853A1 (fr) 2016-12-23 2017-12-21 Inhibiteurs de la matriptase et leurs utilisations

Country Status (3)

Country Link
US (1) US10988505B2 (fr)
CA (4) CA2953168A1 (fr)
WO (1) WO2018112648A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112996529A (zh) * 2018-10-02 2021-06-18 迪斯克医药公司 Matriptase 2抑制剂及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2836511C (fr) 2011-06-02 2021-10-19 SOCPRA Sciences Sante et Humaines S.E.C. Inhibiteurs de matriptase et utilisations de ceux-ci contre les infections a orthomyxoviridae

Also Published As

Publication number Publication date
CA2953166A1 (fr) 2018-06-23
CA3085853A1 (fr) 2018-06-28
US20190337981A1 (en) 2019-11-07
WO2018112648A1 (fr) 2018-06-28
CA2953168A1 (fr) 2018-06-23
US10988505B2 (en) 2021-04-27

Similar Documents

Publication Publication Date Title
RU2607045C2 (ru) Бензиламиновые производные как ингибиторы калликреина плазмы
JP5226679B2 (ja) 酵素阻害のための化合物
JP6034802B2 (ja) 大環状ラクタムの調製のための方法および中間体
JP2001527058A (ja) ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
US10975119B2 (en) Selective cysteine protease inhibitors and uses thereof
JPH06504547A (ja) ペプチドケトアミド、ケト酸およびケトエステル
CA2934964C (fr) Nouveaux derives cyp-eicosanoide
US10988505B2 (en) Matriptase inhibitors and uses thereof
CA3196153A1 (fr) Derives de pyrido[4,3-b]indole et leur utilisation comme produits pharmaceutiques
WO2013070118A1 (fr) Acides (3k,4k,58)-4-acylamion-5-amino-3-(1-étyl-propoxy)-cyclohex-1-ène-carboniques, leurs éthers et procdé d'application
TW201412745A (zh) Ｎ－［２－（｛２－［（２Ｓ）－２－氰基吡咯啶－１－基］－２－側氧乙基｝胺基）－２－甲基丙基］－２－甲基吡唑并［１，５－ａ］嘧啶－６－甲醯胺之結晶
US6172256B1 (en) Chiral-β-amino acid compounds and derivatives thereof
KR20040081182A (ko) 엘라스타제-저해 활성을 가진 이종고리 화합물 및 그 중간체
JP2001139534A (ja) バリン誘導体およびその用途
ZA200300080B (en) Thrombin inhibitors comprising an aminoisoquinoline group.
CN111171025B (zh) 靶向eEF2K降解剂的制备及其抗乳腺癌的应用
CN104529833B (zh) 取代的环丁烷羧酸类化合物及其用途
JPH0548237B2 (fr)
JP2006070014A (ja) ２−アミノベンゾチアゾール誘導体
WO2020010021A1 (fr) Composés et méthodes thérapeutiques

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190716