CA2951063C - Antigen-loaded chitosan nanoparticles for immunotherapy - Google Patents

Antigen-loaded chitosan nanoparticles for immunotherapy Download PDF

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Publication number
CA2951063C
CA2951063C CA2951063A CA2951063A CA2951063C CA 2951063 C CA2951063 C CA 2951063C CA 2951063 A CA2951063 A CA 2951063A CA 2951063 A CA2951063 A CA 2951063A CA 2951063 C CA2951063 C CA 2951063C
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Canada
Prior art keywords
nanoparticles
microparticles
chitosan
kda
antigen
Prior art date
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Application number
CA2951063A
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English (en)
French (fr)
Other versions
CA2951063A1 (en
Inventor
Andrea Hanefeld
Markus Weigandt
Michael Wolf
Percy Knolle
Matthias Schroeder
Regina SCHERLIESS
Peter Walden
Andrea DIEDRICH
Hartwig Steckel
Renato Brito BALEEIRO
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
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Publication of CA2951063A1 publication Critical patent/CA2951063A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2951063A 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy Active CA2951063C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14001974 2014-06-06
EP14001974.6 2014-06-06
PCT/EP2015/000974 WO2015185180A1 (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Publications (2)

Publication Number Publication Date
CA2951063A1 CA2951063A1 (en) 2015-12-10
CA2951063C true CA2951063C (en) 2022-10-04

Family

ID=50897334

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2951063A Active CA2951063C (en) 2014-06-06 2015-05-12 Antigen-loaded chitosan nanoparticles for immunotherapy

Country Status (10)

Country Link
US (1) US10369217B2 (enExample)
EP (1) EP3151856B1 (enExample)
JP (1) JP6730937B2 (enExample)
CN (1) CN106456746B (enExample)
AR (1) AR100745A1 (enExample)
AU (1) AU2015271295B2 (enExample)
CA (1) CA2951063C (enExample)
ES (1) ES2754507T3 (enExample)
IL (1) IL249357B (enExample)
WO (1) WO2015185180A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3698773A1 (en) 2019-02-21 2020-08-26 Università degli Studi di Parma Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination
CN110974805A (zh) * 2019-12-23 2020-04-10 中国科学院海洋研究所 具有增强抗原提呈细胞提呈抗原作用的壳聚糖衍生物纳米粒及制备
GB202018665D0 (en) * 2020-11-26 2021-01-13 Provost Fellows And Scholars Of Trinity College Dublin Immunotherapy for cancer
WO2023168541A1 (en) * 2022-03-09 2023-09-14 Shenzhen Genius Biotech Service Co., Ltd. Chitosan nanoparticles (cnps) and preparation method thereof
WO2024083221A1 (zh) * 2022-10-21 2024-04-25 北京安必奇生物科技有限公司 一种黏膜给药制剂及其制备方法和应用
CN117379393A (zh) * 2023-10-11 2024-01-12 北京安必奇生物科技有限公司 一种核酸药物黏膜给药制剂及其制备方法和应用
CN119506406A (zh) * 2023-08-24 2025-02-25 康希诺生物股份公司 一种表征吸入疫苗性能的方法
CN117398482B (zh) * 2023-09-18 2026-04-24 浙江理工大学 一种卵清蛋白负载硝基自由基氮氧化物纳米复合材料及其制备方法和应用
WO2025209535A1 (en) * 2024-04-03 2025-10-09 Suzhou Xinxin Biopharma Co., Ltd Compositions and associated methods for chitosan-based nano-carriers for therapeutic agents and their applications

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100638041B1 (ko) * 2003-12-24 2006-10-23 주식회사 삼양사 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법
US8137697B1 (en) * 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
EP2397123A1 (en) * 2006-07-07 2011-12-21 Aarhus Universitet Nanoparticles for nucleic acid delivery
WO2008039390A2 (en) * 2006-09-22 2008-04-03 Government Of The Usa., Dept. Of Health & Human Services Compositions and methods for chitosan enhanced immune response
WO2010001932A1 (ja) * 2008-07-01 2010-01-07 日東電工株式会社 表面被覆微粒子の医薬組成物
CN107875127A (zh) * 2012-02-28 2018-04-06 艾塞尤提卡控股公司 可吸入药物组合物

Also Published As

Publication number Publication date
IL249357A0 (en) 2017-02-28
EP3151856B1 (en) 2019-08-07
AU2015271295B2 (en) 2020-04-16
US10369217B2 (en) 2019-08-06
EP3151856A1 (en) 2017-04-12
JP2017516834A (ja) 2017-06-22
CN106456746A (zh) 2017-02-22
IL249357B (en) 2021-01-31
CA2951063A1 (en) 2015-12-10
WO2015185180A1 (en) 2015-12-10
AR100745A1 (es) 2016-10-26
JP6730937B2 (ja) 2020-07-29
ES2754507T3 (es) 2020-04-17
AU2015271295A1 (en) 2017-01-19
US20170143822A1 (en) 2017-05-25
CN106456746B (zh) 2021-03-26

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