CA2950727A1 - Preparation and use of crystalline beta-d-nicotinamide riboside - Google Patents
Preparation and use of crystalline beta-d-nicotinamide riboside Download PDFInfo
- Publication number
- CA2950727A1 CA2950727A1 CA2950727A CA2950727A CA2950727A1 CA 2950727 A1 CA2950727 A1 CA 2950727A1 CA 2950727 A CA2950727 A CA 2950727A CA 2950727 A CA2950727 A CA 2950727A CA 2950727 A1 CA2950727 A1 CA 2950727A1
- Authority
- CA
- Canada
- Prior art keywords
- nicotinamide riboside
- beta
- chloride
- pyridin
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000002360 preparation method Methods 0.000 title abstract description 101
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 125
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- YABIFCKURFRPPO-IVOJBTPCSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride Chemical compound [Cl-].NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 YABIFCKURFRPPO-IVOJBTPCSA-N 0.000 claims description 111
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- 229910019142 PO4 Inorganic materials 0.000 claims description 3
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Landscapes
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| US201462006434P | 2014-06-02 | 2014-06-02 | |
| US62/006,434 | 2014-06-02 | ||
| PCT/IB2015/054181 WO2015186068A1 (en) | 2014-06-02 | 2015-06-02 | Preparation and use of crystalline beta-d-nicotinamide riboside |
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| CA2950727A1 true CA2950727A1 (en) | 2015-12-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4656189A1 (en) | 2023-02-01 | 2025-12-03 | Benethera (Shaoxing) Biotechnology Co., Ltd. | Compound and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2956163C (en) | 2014-07-24 | 2023-01-10 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| ES2963057T3 (es) * | 2015-03-09 | 2024-03-25 | Grace W R & Co | Forma cristalina de ribósido de nicotinamida |
| US9855289B2 (en) | 2015-08-05 | 2018-01-02 | Metro International Biotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| WO2017042198A2 (en) * | 2015-09-08 | 2017-03-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| US10611790B2 (en) | 2015-11-02 | 2020-04-07 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
| CN109562104A (zh) * | 2016-04-14 | 2019-04-02 | 可劳迈戴斯有限公司 | 烟酰胺核苷、烟酸核苷、烟酰胺单核苷酸、和烟碱基化合物衍生物在婴儿配方中的用途 |
| GB2553001A (en) * | 2016-08-19 | 2018-02-21 | The Queen's Univ Of Belfast | Lactone intermediates of nicotinamide riboside and nicotinate riboside |
| JP7132907B2 (ja) | 2016-08-22 | 2022-09-07 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシド及びプテロスチルベン組成物及び神経変性障害の治療方法 |
| NZ803738A (en) | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| EP3554285A4 (en) | 2016-11-29 | 2021-01-20 | University of Iowa Research Foundation | USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring |
| US20190328761A1 (en) | 2016-12-21 | 2019-10-31 | Newsouth Innovations Pty Limited | Methods for enhancing vascular density |
| EP3568488A4 (en) * | 2017-01-13 | 2020-09-23 | The Regents of The University of Colorado, A Body Corporate | METHODS OF TREATMENT OF HYPERTENSION AND ARTERIAL RIGIDITY |
| US11129843B2 (en) | 2017-04-24 | 2021-09-28 | Elysium Health, Inc. | Treating and preventing kidney damage |
| EP3624808A4 (en) * | 2017-05-18 | 2021-03-03 | Elysium Health, Inc. | PROCEDURES AND COMPOSITIONS FOR IMPROVED SLEEP |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| WO2018236747A1 (en) * | 2017-06-21 | 2018-12-27 | Yale University | COMPOUNDS AND COMPOSITIONS FOR EXTENDING THE DURATION OF A SUBJECT |
| JP2020526511A (ja) * | 2017-06-30 | 2020-08-31 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシドの合成方法 |
| KR101990681B1 (ko) * | 2017-07-05 | 2019-06-18 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| KR101982923B1 (ko) * | 2017-07-05 | 2019-05-27 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| EP3727400A4 (en) * | 2017-12-22 | 2021-10-20 | Elysium Health, Inc. | CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE |
| WO2019133815A1 (en) | 2017-12-28 | 2019-07-04 | Kansas State University Research Foundation | Nicotinamide riboside treatments of domesticated meat animals |
| WO2019152416A1 (en) | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN110283221A (zh) * | 2018-03-19 | 2019-09-27 | 药源药物化学（上海）有限公司 | 杂环化合物的制备和纯化方法 |
| WO2019209840A1 (en) * | 2018-04-23 | 2019-10-31 | Elysium Health, Inc. | Methods and compositions for treating rheumatoid arthritis |
| CN110452277A (zh) * | 2018-05-07 | 2019-11-15 | 明特奇点医疗科技(成都)有限公司 | 一种烟酰胺核糖的制备方法 |
| CN112135833A (zh) * | 2018-05-18 | 2020-12-25 | 弗·哈夫曼-拉罗切有限公司 | (硫代)烟酰胺呋喃核糖苷盐及其组合物、制备方法和用途 |
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| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
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| EP4656189A1 (en) | 2023-02-01 | 2025-12-03 | Benethera (Shaoxing) Biotechnology Co., Ltd. | Compound and use thereof |
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