CA2948601A1 - Mth1 inhibitors for treatment of inflammatory and autoimmune conditions - Google Patents

Mth1 inhibitors for treatment of inflammatory and autoimmune conditions Download PDF

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Publication number
CA2948601A1
CA2948601A1 CA2948601A CA2948601A CA2948601A1 CA 2948601 A1 CA2948601 A1 CA 2948601A1 CA 2948601 A CA2948601 A CA 2948601A CA 2948601 A CA2948601 A CA 2948601A CA 2948601 A1 CA2948601 A1 CA 2948601A1
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Canada
Prior art keywords
optionally substituted
groups selected
diamine
chloro
ring
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Abandoned
Application number
CA2948601A
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English (en)
French (fr)
Inventor
Martin Scobie
Olov Wallner
Tobias Koolmeister
Karl Sven Axel VALLIN
Carl Martin HENRIKSSON
Evert Homan
Thomas Helleday
Sylvain JACQUES
Matthieu Desroses
Marie-Caroline JACQUES-CORDONNIER
Roland Julius Yu FISKESUND
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
THOMAS HELLEDAYS STIFTELSE FOR MEDICINSK FORSKNING
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THOMAS HELLEDAYS STIFTELSE FOR MEDICINSK FORSKNING
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Publication of CA2948601A1 publication Critical patent/CA2948601A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52Purines, e.g. adenine
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    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CA2948601A 2014-06-04 2015-06-04 Mth1 inhibitors for treatment of inflammatory and autoimmune conditions Abandoned CA2948601A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1450681-0 2014-06-04
SE1450681 2014-06-04
PCT/SE2015/050654 WO2015187089A1 (en) 2014-06-04 2015-06-04 Mth1 inhibitors for treatment of inflammatory and autoimmune conditions

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CA2948601A1 true CA2948601A1 (en) 2015-12-10

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CA2948601A Abandoned CA2948601A1 (en) 2014-06-04 2015-06-04 Mth1 inhibitors for treatment of inflammatory and autoimmune conditions

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US (2) US10064869B2 (OSRAM)
EP (1) EP3151833A4 (OSRAM)
JP (1) JP6635949B2 (OSRAM)
CN (1) CN106794181A (OSRAM)
AU (1) AU2015268962A1 (OSRAM)
CA (1) CA2948601A1 (OSRAM)
IL (1) IL249223A0 (OSRAM)
RU (1) RU2016151390A (OSRAM)
SG (1) SG11201609981RA (OSRAM)
WO (1) WO2015187089A1 (OSRAM)

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