CA2936952C - Chromene derivatives as cox-2 inhibitors - Google Patents

Chromene derivatives as cox-2 inhibitors Download PDF

Info

Publication number
CA2936952C
CA2936952C CA2936952A CA2936952A CA2936952C CA 2936952 C CA2936952 C CA 2936952C CA 2936952 A CA2936952 A CA 2936952A CA 2936952 A CA2936952 A CA 2936952A CA 2936952 C CA2936952 C CA 2936952C
Authority
CA
Canada
Prior art keywords
chromene
trifluoromethyl
nitrooxy
cancer
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2936952A
Other languages
English (en)
French (fr)
Other versions
CA2936952A1 (en
Inventor
John J. Talley
Eduardo J. Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euclises Pharmaceuticals Inc
Original Assignee
Euclises Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euclises Pharmaceuticals Inc filed Critical Euclises Pharmaceuticals Inc
Publication of CA2936952A1 publication Critical patent/CA2936952A1/en
Application granted granted Critical
Publication of CA2936952C publication Critical patent/CA2936952C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2936952A 2014-01-14 2015-01-14 Chromene derivatives as cox-2 inhibitors Active CA2936952C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461927344P 2014-01-14 2014-01-14
US61/927,344 2014-01-14
PCT/US2015/011454 WO2015109011A1 (en) 2014-01-14 2015-01-14 No-releasing nitrooxy-chromene conjugates

Publications (2)

Publication Number Publication Date
CA2936952A1 CA2936952A1 (en) 2015-07-23
CA2936952C true CA2936952C (en) 2023-01-24

Family

ID=53543408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2936952A Active CA2936952C (en) 2014-01-14 2015-01-14 Chromene derivatives as cox-2 inhibitors

Country Status (10)

Country Link
US (1) US10266511B2 (pt)
EP (1) EP3094333B1 (pt)
CN (1) CN106102747A (pt)
AU (1) AU2015206528B2 (pt)
BR (1) BR112016016386B1 (pt)
CA (1) CA2936952C (pt)
ES (1) ES2836374T3 (pt)
IL (1) IL246794B (pt)
MX (1) MX369245B (pt)
WO (2) WO2015109013A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105585547A (zh) * 2016-03-09 2016-05-18 中国科学院广州生物医药与健康研究院 一种4-五氟化硫苯酚类化合物及制备方法以及五氟化硫取代苯并吡喃类化合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050101563A1 (en) * 2001-08-14 2005-05-12 Pharmacia Corporation Method and compositions for the treatment and prevention of pain and inflammation
ITMI20021391A1 (it) 2002-06-25 2003-12-29 Nicox Sa Nitroderivati di inibitori della cicloossigenasi-2
CA2503063A1 (en) 2002-10-22 2004-05-06 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Nitric oxide releasing selective cyclooxygenase-2 inhibitors
CA2518506A1 (en) 2003-03-13 2004-11-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
US20050148627A1 (en) * 2003-03-31 2005-07-07 Jeffery Carter Benzopyran compounds for use in the treatment and prevention of inflammation related conditions
US7259266B2 (en) * 2003-03-31 2007-08-21 Pharmacia Corporation Benzopyran compounds useful for treating inflammatory conditions
US20080287407A1 (en) 2003-12-10 2008-11-20 Nitromed, Inc. Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
WO2006040646A1 (en) * 2004-10-14 2006-04-20 Pfizer, Inc. Benzimidazole or indole amides as inhibitors of pin1
WO2009009776A2 (en) 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Patient selection and therapeutic methods using markers of prostaglandin metabolism
CN103012350B (zh) * 2012-12-07 2015-02-04 中国科学院广州生物医药与健康研究院 苯并吡喃类手性化合物的合成方法

Also Published As

Publication number Publication date
CN106102747A (zh) 2016-11-09
AU2015206528B2 (en) 2019-04-18
WO2015109011A1 (en) 2015-07-23
ES2836374T3 (es) 2021-06-24
EP3094333A4 (en) 2017-09-06
EP3094333B1 (en) 2020-10-14
MX369245B (es) 2019-11-01
EP3094333A1 (en) 2016-11-23
AU2015206528A1 (en) 2016-08-04
US10266511B2 (en) 2019-04-23
BR112016016386B1 (pt) 2023-02-23
WO2015109013A1 (en) 2015-07-23
IL246794B (en) 2020-04-30
BR112016016386A2 (pt) 2017-08-08
MX2016009222A (es) 2017-03-06
CA2936952A1 (en) 2015-07-23
US20160340330A1 (en) 2016-11-24
IL246794A0 (en) 2016-08-31

Similar Documents

Publication Publication Date Title
EP3445749B1 (en) Compounds and compositions for treating conditions associated with nlrp activity
CN105008343B (zh) 作为选择性雌激素受体降解剂的苯并噻吩衍生物及其组合物
CN111770914B (zh) 作为神经激肽-1受体拮抗剂的化合物及其用途
ES2371932T3 (es) Derivados de pirazina como moduladores de los canales de sodio para el tratamiento del dolor.
JP5944823B2 (ja) 複素環化合物及びｐ２７Ｋｉｐ１分解阻害剤
CN106478500B (zh) 羧酸取代的（杂）芳环类衍生物及其制备方法和用途
US10676438B2 (en) KCNQ2-5 channel activator
JP6315848B2 (ja) Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法
WO2016155545A1 (zh) 含氨磺酰基的1,2,5-噁二唑类衍生物、其制备方法及其在医药上的应用
CN103189361A (zh) 雌激素受体调节剂及其用途
KR20220052918A (ko) 치료제로서의 사이토톡신의 펩티드 접합체
WO2017101791A1 (zh) 化合物及其在制备药物中的用途
CN117597341A (zh) 磺酰胺衍生物、其制备方法及其在医药上的应用
CN109963836B (zh) 氘原子取代的吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
WO2015109014A1 (en) No-releasing nonoate(oxygen-bound)chromene conjugates
US20150197500A1 (en) No-releasing guanidine-chromene conjugates
CA2936952C (en) Chromene derivatives as cox-2 inhibitors
US9044464B2 (en) No-releasing guanidine-coxib anti-cancer agents
JP2023531020A (ja) スルホン誘導体
US20150197494A1 (en) No-releasing nitrooxy-methylene-linked-coxib conjugates
WO2024109917A1 (zh) 一种三唑衍生物及其在医药上的应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200110

EEER Examination request

Effective date: 20200110

EEER Examination request

Effective date: 20200110

EEER Examination request

Effective date: 20200110

EEER Examination request

Effective date: 20200110

EEER Examination request

Effective date: 20200110