CA2933548C - Structured substrates for improving detection of light emissions and methods relating to the same - Google Patents

Structured substrates for improving detection of light emissions and methods relating to the same Download PDF

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Publication number
CA2933548C
CA2933548C CA2933548A CA2933548A CA2933548C CA 2933548 C CA2933548 C CA 2933548C CA 2933548 A CA2933548 A CA 2933548A CA 2933548 A CA2933548 A CA 2933548A CA 2933548 C CA2933548 C CA 2933548C
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nanostructures
plasmonic nanostructures
nanoparticles
array according
reaction
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English (en)
French (fr)
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CA2933548A1 (en
Inventor
M. Shane Bowen
Bala Murali VENKATESAN
Hui Han
Sang Ryul Park
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Illumina Inc
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Illumina Inc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/628—Detection means characterised by use of a special device being a surface plasmon resonance spectrometer

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2933548A 2013-12-23 2014-12-23 Structured substrates for improving detection of light emissions and methods relating to the same Active CA2933548C (en)

Priority Applications (1)

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CA3198424A CA3198424A1 (en) 2013-12-23 2014-12-23 Structured substrates for improving detection of light emissions and methods relating to the same

Applications Claiming Priority (3)

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US201361920244P 2013-12-23 2013-12-23
US61/920,244 2013-12-23
PCT/US2014/072256 WO2015100373A2 (en) 2013-12-23 2014-12-23 Structured substrates for improving detection of light emissions and methods relating to the same

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CA2933548A1 CA2933548A1 (en) 2015-07-02
CA2933548C true CA2933548C (en) 2023-07-11

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US (2) US20180073065A1 (enExample)
EP (2) EP3778890B1 (enExample)
JP (1) JP7082860B2 (enExample)
KR (2) KR102333635B1 (enExample)
CN (1) CN106062212A (enExample)
AU (1) AU2014369879B2 (enExample)
BR (1) BR112016014923B1 (enExample)
CA (2) CA2933548C (enExample)
ES (1) ES2848062T3 (enExample)
WO (1) WO2015100373A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12324663B2 (en) 2014-05-12 2025-06-10 President And Fellows Of Harvard College Systems and methods for making and using sensors, probes, and other devices
US9861710B1 (en) * 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
CN108449971B (zh) * 2015-04-14 2020-10-16 亿明达股份有限公司 用于改进对光发射的检测的结构化基底及涉及其的方法
CA2986072C (en) 2015-06-01 2023-05-02 California Institute Of Technology Compositions and methods for screening t cells with antigens for specific populations
AT517746B1 (de) * 2015-09-16 2018-03-15 Fianostics Gmbh Substrat
WO2017164403A1 (ja) * 2016-03-25 2017-09-28 大日本印刷株式会社 電磁波応答性積層体
US12258613B2 (en) 2017-03-08 2025-03-25 California Institute Of Technology Pairing antigen specificity of a T cell with T cell receptor sequences
CN106873234B (zh) * 2017-03-16 2019-10-25 京东方科技集团股份有限公司 发光显示器件及其制作方法、发光显示装置
WO2018222839A1 (en) 2017-06-01 2018-12-06 Radiabeam Technologies, Llc Split structure particle accelerators
JP7043051B2 (ja) * 2017-09-01 2022-03-29 学校法人関西学院 表面プラズモン励起増強蛍光検出装置および検出方法
WO2019051181A1 (en) 2017-09-08 2019-03-14 President And Fellows Of Harvard College METHODS AND APPARATUSES BASED ON NANOCAPTERS FOR THE DETERMINATION OF ANALYTES
RU2751517C2 (ru) 2017-12-21 2021-07-14 Иллюмина, Инк. Проточные ячейки с покрытием из гидрогеля
WO2019200265A1 (en) * 2018-04-14 2019-10-17 Centrillion Technologies, Inc. Dna bridge methods for capturing dna molecules
CN112041666B (zh) * 2018-08-24 2024-08-20 松下知识产权经营株式会社 金属微细结构体和检测装置
CN112005101A (zh) * 2018-08-28 2020-11-27 松下知识产权经营株式会社 传感器基板及其制造方法
WO2020049557A1 (en) * 2018-09-06 2020-03-12 Ramot At Tel-Aviv University Ltd. Method of producing metal nanoparticles and uses thereof
WO2020061204A1 (en) 2018-09-21 2020-03-26 Radiabeam Technologies, Llc Modified split structure particle accelerators
US11841310B2 (en) 2018-12-17 2023-12-12 Illumina, Inc. Flow cells and sequencing kits
EP3931561A4 (en) 2019-02-27 2022-11-09 NanoMosaic Inc. NANOSENSORS AND USE THEREOF
NL2023516B1 (en) * 2019-05-28 2020-12-08 Illumina Inc Manufacturing a flowcell with a planar waveguide
CN110218628B (zh) * 2019-06-19 2021-01-29 中国科学院半导体研究所 一种数字pcr芯片及其制备方法
WO2021215541A1 (ja) * 2020-04-20 2021-10-28 公立大学法人大阪 センサー
EP4244377B1 (en) 2020-11-16 2025-10-29 Illumina Cambridge Limited Functionalized plasmonic nanostructures
MX2022014810A (es) * 2020-11-16 2023-03-06 Illumina Cambridge Ltd Alteración de señales de celdas de flujo.
KR102760542B1 (ko) * 2021-06-29 2025-02-03 광주과학기술원 측면 흐름 분석-기반의 면역 검출용 이중 나노입자 및 이를 이용한 면역 검출 센서
WO2023205353A1 (en) * 2022-04-21 2023-10-26 Ultima Genomics, Inc. Self assembly of beads on substrates
US12055737B2 (en) * 2022-05-18 2024-08-06 GE Precision Healthcare LLC Aligned and stacked high-aspect ratio metallized structures
CN115639185B (zh) * 2022-11-04 2025-07-15 东南大学 一种a-b-a纳米三聚体阵列的制备方法及应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US7172864B1 (en) * 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20050244870A1 (en) 1999-04-20 2005-11-03 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
EP1368460B1 (en) 2000-07-07 2007-10-31 Visigen Biotechnologies, Inc. Real-time sequence determination
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
WO2004018497A2 (en) 2002-08-23 2004-03-04 Solexa Limited Modified nucleotides for polynucleotide sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
EP1636337A4 (en) 2003-06-20 2007-07-04 Illumina Inc METHODS AND COMPOSITIONS USEFUL FOR THE AMPLIFICATION AND GENOTYPING OF THE GENOME
ES2949821T3 (es) 2004-01-07 2023-10-03 Illumina Cambridge Ltd Matrices moleculares
AU2005296200B2 (en) 2004-09-17 2011-07-14 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7274458B2 (en) * 2005-03-07 2007-09-25 3M Innovative Properties Company Thermoplastic film having metallic nanoparticle coating
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP5122555B2 (ja) 2006-03-31 2013-01-16 ソレクサ・インコーポレイテッド 合成解析による配列決定システムおよび装置
KR20090067174A (ko) * 2006-09-14 2009-06-24 더 리전트 오브 더 유니버시티 오브 캘리포니아 뉴클레아제 활성 및 ｄｎａ 풋프린팅을 위한 나노플라즈몬 분자 계측자
EP2089517A4 (en) 2006-10-23 2010-10-20 Pacific Biosciences California POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
JP5268444B2 (ja) * 2008-06-23 2013-08-21 株式会社日立ハイテクノロジーズ 単分子リアルタイムシーケンス装置，核酸分析装置及び単分子リアルタイムシーケンス方法
EP2338053A1 (en) * 2008-09-12 2011-06-29 Modpro AB Detection method and device based on nanoparticle aggregation
KR101041606B1 (ko) * 2009-08-18 2011-06-15 (주)아벨리노 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법
WO2011112465A1 (en) 2010-03-06 2011-09-15 Illumina, Inc. Systems, methods, and apparatuses for detecting optical signals from a sample
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
WO2012024658A2 (en) * 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012103110A2 (en) 2011-01-24 2012-08-02 Mohammad Naraghi Building facade surface for seasonal selectiveness of solar irradiation absorption and reflection
US8796185B2 (en) * 2011-03-08 2014-08-05 Lightspeed Genomics, Inc. Self-assembling high density ordered patterned biomolecule array and method for making and using the same
US9671327B2 (en) * 2011-03-18 2017-06-06 The Regents Of The University Of Colorado, A Body Corporate Ultrasensitive biochemical sensing device and method of sensing analytes
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
WO2013063382A2 (en) * 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
AU2013246359B2 (en) * 2012-04-10 2017-03-30 The Trustees Of Princeton University Ultra-sensitive sensor
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US9592001B2 (en) * 2012-07-29 2017-03-14 Hewlett-Packard Development Company, L.P. Implantable nanosensor
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
CN103308462A (zh) * 2013-06-26 2013-09-18 南京邮电大学 银金核-卫星结构表面等离子体共振探针及其制备方法

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