CA2932021A1 - Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing - Google Patents

Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing Download PDF

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Publication number
CA2932021A1
CA2932021A1 CA2932021A CA2932021A CA2932021A1 CA 2932021 A1 CA2932021 A1 CA 2932021A1 CA 2932021 A CA2932021 A CA 2932021A CA 2932021 A CA2932021 A CA 2932021A CA 2932021 A1 CA2932021 A1 CA 2932021A1
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Canada
Prior art keywords
seq
cells
peptide
hydrogel
peptidomimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA2932021A
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English (en)
French (fr)
Inventor
Charlotte Hauser
Yihua LOO
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Agency for Science Technology and Research Singapore
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Agency for Science Technology and Research Singapore
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Publication of CA2932021A1 publication Critical patent/CA2932021A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Peptides Or Proteins (AREA)
CA2932021A 2013-11-30 2014-12-01 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing Abandoned CA2932021A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SG2013088919 2013-11-30
SG201308891-9 2013-11-30
PCT/SG2014/000569 WO2015080671A1 (en) 2013-11-30 2014-12-01 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing

Publications (1)

Publication Number Publication Date
CA2932021A1 true CA2932021A1 (en) 2015-06-04

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ID=56101817

Family Applications (1)

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CA2932021A Abandoned CA2932021A1 (en) 2013-11-30 2014-12-01 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing

Country Status (11)

Country Link
US (1) US10179194B2 (enExample)
EP (1) EP3074416A4 (enExample)
JP (1) JP2017501136A (enExample)
KR (1) KR20160091993A (enExample)
CN (1) CN105960411A (enExample)
AU (1) AU2014355214A1 (enExample)
BR (1) BR112016012128A2 (enExample)
CA (1) CA2932021A1 (enExample)
HK (1) HK1225745A1 (enExample)
MX (1) MX2016006990A (enExample)
WO (1) WO2015080671A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021223674A1 (en) * 2020-05-05 2021-11-11 International Business Machines Corporation Bioprinted living tissue with therapy capability

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9815871B2 (en) 2013-04-23 2017-11-14 President And Fellows Of Harvard College Genetic reprogramming of bacterial biofilms
EP3074415A4 (en) * 2013-11-30 2017-09-20 Agency For Science, Technology And Research Novel ultrashort hydrophobic peptides that self-assemble into nanofibrous hydrogels and their uses
WO2015080671A1 (en) 2013-11-30 2015-06-04 Agency For Science, Technology And Research Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing
SG11201708050RA (en) * 2015-03-31 2017-10-30 Agency Science Tech & Res Self-assembling ultrashort aliphatic cyclic peptides for biomedical applications
JP6916524B2 (ja) 2015-04-06 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的タンパク質配列をディスプレイする生合成アミロイドに基づく材料
US10058502B2 (en) 2015-12-31 2018-08-28 L'oreal Nail polish compositions
US11098133B2 (en) * 2016-05-19 2021-08-24 President And Fellows Of Harvard College Methods of making gels and films using curli nanofibers
CN107915848A (zh) * 2016-10-11 2018-04-17 中国海洋大学 一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法
EP3551240A1 (en) * 2016-12-09 2019-10-16 Biogelx Limited 3d printing and drug delivery
CN106699841B (zh) * 2017-01-05 2020-07-24 北京大学深圳研究生院 一种自组装的多肽纳米棒及其制备方法
CN106946982B (zh) * 2017-03-29 2020-08-28 中国石油大学(华东) 一种具有抗肿瘤功能的多肽
WO2018207036A1 (en) * 2017-05-11 2018-11-15 King Abdullah University Of Science And Technology A peptide capable of forming a gel for use in tissue engineering and bioprinting
KR102418307B1 (ko) * 2017-05-11 2022-07-06 킹 압둘라 유니버시티 오브 사이언스 앤드 테크놀로지 미세유체공학-기반 3d 바이오프린팅용 장치 및 방법
US11534401B2 (en) * 2017-11-07 2022-12-27 The Royal College Of Surgeons In Ireland Thermo-responsive hydrogel for intratumoral administration as a treatment in solid tumor cancers
KR102219828B1 (ko) * 2018-04-11 2021-02-24 연세대학교 산학협력단 pH 감응성 펩타이드 구조체, 및 이의 용도
AU2019288588B2 (en) 2018-06-21 2024-06-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ECM) hydrogel as a submucosal fluid cushion
CA3103973A1 (en) * 2018-06-21 2019-12-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of a urinary bladder ecm hydrogel as an esophageal submucosal fluid cushion
SG11202100335QA (en) * 2018-07-24 2021-02-25 Newsouth Innovations Pty Ltd Bio-ink for 3d printing
CN109276755B (zh) * 2018-10-11 2021-04-20 山东大学齐鲁医院(青岛) 基于自组装纳米多肽和干细胞的3d打印组织工程血管及其制备方法
ES2754824A1 (es) * 2018-10-17 2020-04-20 Univ Valladolid Composicion a base de biopolimeros recombinantes y usos de la misma como biotinta
CN109730976B (zh) * 2018-12-24 2020-06-09 华中科技大学 一种基于自由基氧化制备白蛋白纳米粒的方法
CN110394985B (zh) * 2019-06-21 2021-08-20 南京大学 一种利用Taylor喷射效应构造双层液锥进行三维连续分子自组装的装置及其方法
KR102228400B1 (ko) * 2019-09-24 2021-03-16 고려대학교 산학협력단 뇌 오가노이드 제조 방법
WO2021111503A1 (ja) * 2019-12-02 2021-06-10 花王株式会社 光吸収層及びその製造方法、分散液、光電変換素子、並びに太陽電池
CN111840636B (zh) * 2020-07-30 2022-01-18 齐鲁工业大学 伯氨基暴露量为5％的多肽单层膜及其制备方法与应用
WO2022035778A1 (en) * 2020-08-10 2022-02-17 Gel4Med, Inc. Delivery of cells and tissues with self-assembling peptide hydrogel materials
US11673324B2 (en) 2020-08-20 2023-06-13 King Abdullah University Of Science And Technology Nozzle for 3D bioprinting
US12109327B2 (en) 2020-08-20 2024-10-08 King Abdullah University Of Science And Technology Scaffolds from self-assembling tetrapeptides support 3D spreading, osteogenic differentiation and angiogenesis of mesenchymal stem cells
US20220056074A1 (en) * 2020-08-20 2022-02-24 King Abdullah University Of Science And Technology Peptide compound with repetitive sequences
WO2022049508A1 (en) * 2020-09-02 2022-03-10 King Adbullah University Of Science And Technology Peptide-based dopa containing adhesive gels
WO2022049494A1 (en) * 2020-09-02 2022-03-10 King Adbullah University Of Science And Technology Air-loaded gas vesicle nanoparticles for promoting cell growth in 3d bioprinted tissue constructs
EP4232558A4 (en) * 2020-10-21 2024-10-16 King Abdullah University Of Science And Technology DELIVERY OF ENDOTHELIAL CELL-LOADED MICROGEL INDUCING ANGIOGENESIS IN SELF-ASSEMBLED ULTRASHORT PEPTIDE HYDROGELS
WO2022107089A1 (en) 2020-11-23 2022-05-27 King Adbullah University Of Science And Technology Developing lateral flow immunochromatography (lfia) peptide-based test strips for rapid detection of antigens and antibodies against specific antigens
CN112263547B (zh) * 2020-11-26 2022-12-20 深圳大学 一种多功能纳米药物载体及其制备方法与载药组合物
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
CN113321706B (zh) * 2021-07-15 2022-01-07 南开大学 一种自组装多肽衍生物及其制备的水凝胶
CN115583990B (zh) * 2022-11-22 2023-04-21 潍坊医学院 一种响应性小分子肽、纳米载药载体及应用
GB2628663A (en) * 2023-03-31 2024-10-02 Univ Belfast An injectable delivery system for long-acting administration of drugs
WO2024233707A1 (en) * 2023-05-09 2024-11-14 William Marsh Rice University 3d printing of self-assembling multidomain peptide hydrogels and fabrication of aligned nanofibrous self-assembling peptide hydrogels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003079985A2 (en) 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
CA2701884A1 (en) 2007-10-15 2009-04-23 Wake Forest University Health Sciences Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
US8999916B2 (en) * 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
US9067084B2 (en) * 2010-03-31 2015-06-30 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
BR112014005746A2 (pt) * 2011-09-12 2017-03-28 Organovo Inc tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos
SG11201401964TA (en) * 2011-11-04 2014-05-29 Agency Science Tech & Res Self-assembled composite ultrasmall peptide-polymer hydrogels
SG193042A1 (en) 2012-02-22 2013-09-30 Agency Science Tech & Res Organogels from ultrasmall peptides that can be used for biological and non-biological applications
GB201203085D0 (en) 2012-02-22 2012-04-04 Univ Manchester Hydrogels
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
WO2014104974A2 (en) * 2012-12-24 2014-07-03 Agency For Science, Technology And Research Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
SG2012096699A (en) 2012-12-31 2014-07-30 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
CN105102469A (zh) * 2013-01-28 2015-11-25 新加坡科技研究局 交联的肽水凝胶
CN105828838B (zh) * 2013-10-18 2020-03-10 新加坡科技研究局 含有纳米粒子的水凝胶
EP3074415A4 (en) 2013-11-30 2017-09-20 Agency For Science, Technology And Research Novel ultrashort hydrophobic peptides that self-assemble into nanofibrous hydrogels and their uses
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MX2016006990A (es) 2017-05-04
EP3074416A4 (en) 2017-09-13
KR20160091993A (ko) 2016-08-03
CN105960411A (zh) 2016-09-21
US10179194B2 (en) 2019-01-15
US20160375177A1 (en) 2016-12-29
AU2014355214A1 (en) 2016-07-07
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