BR112016012128A2 - Uso de um peptídeo e/ou peptidomimético, capaz de automontar e formar um hidrogel, método para preparar um hidrogel, método para preparar fibras contínuas, uso de um hidrogel, método para obter um vetor multicelular, vetor multicelular e uso de um vetor biológico 3d - Google Patents

Uso de um peptídeo e/ou peptidomimético, capaz de automontar e formar um hidrogel, método para preparar um hidrogel, método para preparar fibras contínuas, uso de um hidrogel, método para obter um vetor multicelular, vetor multicelular e uso de um vetor biológico 3d

Info

Publication number
BR112016012128A2
BR112016012128A2 BR112016012128A BR112016012128A BR112016012128A2 BR 112016012128 A2 BR112016012128 A2 BR 112016012128A2 BR 112016012128 A BR112016012128 A BR 112016012128A BR 112016012128 A BR112016012128 A BR 112016012128A BR 112016012128 A2 BR112016012128 A2 BR 112016012128A2
Authority
BR
Brazil
Prior art keywords
hydrogel
vector
preparing
multicell
obtaining
Prior art date
Application number
BR112016012128A
Other languages
English (en)
Portuguese (pt)
Inventor
Hauser Charlotte
LOO Yihua
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of BR112016012128A2 publication Critical patent/BR112016012128A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
BR112016012128A 2013-11-30 2014-12-01 Uso de um peptídeo e/ou peptidomimético, capaz de automontar e formar um hidrogel, método para preparar um hidrogel, método para preparar fibras contínuas, uso de um hidrogel, método para obter um vetor multicelular, vetor multicelular e uso de um vetor biológico 3d BR112016012128A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG2013088919 2013-11-30
PCT/SG2014/000569 WO2015080671A1 (en) 2013-11-30 2014-12-01 Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing

Publications (1)

Publication Number Publication Date
BR112016012128A2 true BR112016012128A2 (pt) 2017-08-08

Family

ID=56101817

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016012128A BR112016012128A2 (pt) 2013-11-30 2014-12-01 Uso de um peptídeo e/ou peptidomimético, capaz de automontar e formar um hidrogel, método para preparar um hidrogel, método para preparar fibras contínuas, uso de um hidrogel, método para obter um vetor multicelular, vetor multicelular e uso de um vetor biológico 3d

Country Status (11)

Country Link
US (1) US10179194B2 (enExample)
EP (1) EP3074416A4 (enExample)
JP (1) JP2017501136A (enExample)
KR (1) KR20160091993A (enExample)
CN (1) CN105960411A (enExample)
AU (1) AU2014355214A1 (enExample)
BR (1) BR112016012128A2 (enExample)
CA (1) CA2932021A1 (enExample)
HK (1) HK1225745A1 (enExample)
MX (1) MX2016006990A (enExample)
WO (1) WO2015080671A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6618892B2 (ja) 2013-04-23 2019-12-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 細菌バイオフィルムの遺伝的リプログラミング
EP3074416A4 (en) 2013-11-30 2017-09-13 Agency for Science, Technology and Research Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing
CN106414477A (zh) * 2013-11-30 2017-02-15 新加坡科技研究局 自组装为纳米纤维水凝胶的新超短疏水性肽及其用途
CN107406486A (zh) * 2015-03-31 2017-11-28 新加坡科技研究局 用于生物医学应用的自组装超短脂族环肽
EP3280397A4 (en) 2015-04-06 2018-08-22 President and Fellows of Harvard College Biosynthetic amyloid-based materials displaying functional protein sequences
US10058502B2 (en) 2015-12-31 2018-08-28 L'oreal Nail polish compositions
WO2017201428A1 (en) * 2016-05-19 2017-11-23 President And Fellows Of Harvard College Methods of making gels and film using curli nanofibers
CN107915848A (zh) * 2016-10-11 2018-04-17 中国海洋大学 一种甲壳素晶须/羟丁基壳聚糖温敏水凝胶的制备方法
US20190321291A1 (en) * 2016-12-09 2019-10-24 Biogelx Limited 3D Printing and Drug Delivery
CN106699841B (zh) * 2017-01-05 2020-07-24 北京大学深圳研究生院 一种自组装的多肽纳米棒及其制备方法
CN106946982B (zh) * 2017-03-29 2020-08-28 中国石油大学(华东) 一种具有抗肿瘤功能的多肽
US11702623B2 (en) 2017-05-11 2023-07-18 King Abdullah University Of Science And Technology Device and method for microfluidics-based 3D bioprinting
SG11201910191RA (en) * 2017-05-11 2019-11-28 Univ King Abdullah Sci & Tech A peptide capable of forming a gel for use in tissue engineering and bioprinting
CN111615380B (zh) * 2017-11-07 2024-08-23 爱尔兰皇家外科医学院 用于作为实体瘤癌症的治疗的瘤内给药的热响应性水凝胶
KR102219828B1 (ko) * 2018-04-11 2021-02-24 연세대학교 산학협력단 pH 감응성 펩타이드 구조체, 및 이의 용도
JP2021527518A (ja) * 2018-06-21 2021-10-14 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 食道粘膜下流体クッションとしての膀胱ｅｃｍヒドロゲルの使用
CA3103093A1 (en) 2018-06-21 2019-12-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ecm) hydrogel as a submucosal fluid cushion
AU2019310647B2 (en) * 2018-07-24 2025-03-06 Newsouth Innovations Pty Limited Bio-ink for 3D printing
CN109276755B (zh) * 2018-10-11 2021-04-20 山东大学齐鲁医院(青岛) 基于自组装纳米多肽和干细胞的3d打印组织工程血管及其制备方法
ES2754824A1 (es) * 2018-10-17 2020-04-20 Univ Valladolid Composicion a base de biopolimeros recombinantes y usos de la misma como biotinta
CN109730976B (zh) * 2018-12-24 2020-06-09 华中科技大学 一种基于自由基氧化制备白蛋白纳米粒的方法
CN110394985B (zh) * 2019-06-21 2021-08-20 南京大学 一种利用Taylor喷射效应构造双层液锥进行三维连续分子自组装的装置及其方法
KR102228400B1 (ko) * 2019-09-24 2021-03-16 고려대학교 산학협력단 뇌 오가노이드 제조 방법
WO2021111503A1 (ja) * 2019-12-02 2021-06-10 花王株式会社 光吸収層及びその製造方法、分散液、光電変換素子、並びに太陽電池
US11559389B2 (en) * 2020-05-05 2023-01-24 International Business Machines Corporation Bioprinted living tissue with therapy capability
CN111840636B (zh) * 2020-07-30 2022-01-18 齐鲁工业大学 伯氨基暴露量为5％的多肽单层膜及其制备方法与应用
CA3188208A1 (en) * 2020-08-10 2022-02-17 Yewoo LEE Delivery of cells and tissues with self-assembling peptide hydrogel materials
US11673324B2 (en) 2020-08-20 2023-06-13 King Abdullah University Of Science And Technology Nozzle for 3D bioprinting
US20220056074A1 (en) * 2020-08-20 2022-02-24 King Abdullah University Of Science And Technology Peptide compound with repetitive sequences
US12109327B2 (en) 2020-08-20 2024-10-08 King Abdullah University Of Science And Technology Scaffolds from self-assembling tetrapeptides support 3D spreading, osteogenic differentiation and angiogenesis of mesenchymal stem cells
US20230279344A1 (en) * 2020-09-02 2023-09-07 King Abdullah University Of Science And Technology Air-loaded gas vesicle nanoparticles for promoting cell growth in 3d bioprinted tissue constructs
US12116421B2 (en) 2020-09-02 2024-10-15 King Abdullah University Of Science And Technology Peptide-based Dopa containing adhesive gels
WO2022084874A1 (en) * 2020-10-21 2022-04-28 King Adbullah University Of Science And Technology Delivery of endothelial cell-laden microgel elicits angiogenesis in self-assembling ultrashort peptide hydrogels
US11994520B2 (en) 2020-11-23 2024-05-28 King Abdullah University Of Science And Technology Developing lateral flow immunochromatography (LFIA) peptide-based test strips for rapid detection of antigens and antibodies against specific antigens
CN112263547B (zh) * 2020-11-26 2022-12-20 深圳大学 一种多功能纳米药物载体及其制备方法与载药组合物
KR20230158005A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출
CN113321706B (zh) * 2021-07-15 2022-01-07 南开大学 一种自组装多肽衍生物及其制备的水凝胶
CN115583990B (zh) * 2022-11-22 2023-04-21 潍坊医学院 一种响应性小分子肽、纳米载药载体及应用
GB2628663A (en) * 2023-03-31 2024-10-02 Univ Belfast An injectable delivery system for long-acting administration of drugs
WO2024233707A1 (en) * 2023-05-09 2024-11-14 William Marsh Rice University 3d printing of self-assembling multidomain peptide hydrogels and fabrication of aligned nanofibrous self-assembling peptide hydrogels

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003224710A1 (en) 2002-03-18 2003-10-08 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
EP2203129A4 (en) 2007-10-15 2011-11-23 Univ Wake Forest Health Sciences METHOD AND COMPOSITIONS FOR PRINTING BIOCOMPATIBLE NANOROUS COMPOSITES FROM AUTOLOGOUS TISSUE
WO2011123061A1 (en) * 2010-03-31 2011-10-06 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8999916B2 (en) * 2010-03-31 2015-04-07 Agency For Science, Technology And Research Crosslinked peptide hydrogels
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
BR112014005746A2 (pt) 2011-09-12 2017-03-28 Organovo Inc tecidos engendrados para usos em pesquisa in vitro, arranjos destes, e métodos de fabricar os mesmos
US10449257B2 (en) * 2011-11-04 2019-10-22 Agency For Science, Technology And Research Self-assembled composite ultrasmall peptide-polymer hydrogels
SG193042A1 (en) * 2012-02-22 2013-09-30 Agency Science Tech & Res Organogels from ultrasmall peptides that can be used for biological and non-biological applications
GB201203085D0 (en) 2012-02-22 2012-04-04 Univ Manchester Hydrogels
US9120841B2 (en) * 2012-09-28 2015-09-01 Agency For Science, Technology And Research Amphiphilic linear peptidepeptoid and hydrogel comprising the same
US10117946B2 (en) * 2012-12-24 2018-11-06 Agency For Science, Technology And Research Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
SG2012096699A (en) 2012-12-31 2014-07-30 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
WO2014116187A1 (en) * 2013-01-28 2014-07-31 Agency For Science, Technology And Research Crosslinked peptide hydrogels
WO2015057170A1 (en) * 2013-10-18 2015-04-23 Agency For Science, Technology And Research Nanoparticle-containing hydrogels
EP3074416A4 (en) 2013-11-30 2017-09-13 Agency for Science, Technology and Research Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing
CN106414477A (zh) 2013-11-30 2017-02-15 新加坡科技研究局 自组装为纳米纤维水凝胶的新超短疏水性肽及其用途

Also Published As

Publication number Publication date
HK1225745A1 (zh) 2017-09-15
US20160375177A1 (en) 2016-12-29
KR20160091993A (ko) 2016-08-03
MX2016006990A (es) 2017-05-04
CN105960411A (zh) 2016-09-21
WO2015080671A1 (en) 2015-06-04
JP2017501136A (ja) 2017-01-12
AU2014355214A1 (en) 2016-07-07
CA2932021A1 (en) 2015-06-04
EP3074416A1 (en) 2016-10-05
EP3074416A4 (en) 2017-09-13
US10179194B2 (en) 2019-01-15

Similar Documents

Publication Publication Date Title
BR112016012128A2 (pt) Uso de um peptídeo e/ou peptidomimético, capaz de automontar e formar um hidrogel, método para preparar um hidrogel, método para preparar fibras contínuas, uso de um hidrogel, método para obter um vetor multicelular, vetor multicelular e uso de um vetor biológico 3d
MX2017006866A (es) Pares de unión para producción de péptidos.
MX2016006988A (es) Nuevos peptidos hidrofobos ultracortos que se autoensamblan en hidrogeles nanofibrosos y sus usos.
MX2019006374A (es) Receptores inmunes sinteticos y metodos de usos de ellos.
PH12018501280A1 (en) Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
MX2023011785A (es) Metodos y composiciones para produccion de proteina de clara de huevo.
MX384212B (es) Metodos para cosechar cultivos de celulas de mamifero.
MX392416B (es) Métodos y composiciones para terapia celular adoptiva.
WO2016070166A3 (en) Messenger una molecules and uses thereof
PH12017501115A1 (en) Anti-myostatin antibodies, polypeptides containing variant fc regions, and method of use
BR112017014031A2 (pt) n-oligossacaril-transferase recombinante, mutante de n-oligossacaril-transferase recombinante, ácido nucleico, célula hospedeira, e, método para produção de um bioconjugado.
PH12015502125A1 (en) Il-22 polypeptides and il-22 fc fusion proteins and methods of use
WO2015109323A3 (en) Systems and methods for three-dimensional imaging
EP2866640A4 (en) MULTI-VIEW IRIDOCORNENE ANGULAR OPHTHALMIC IMAGING SYSTEM
CY1117214T1 (el) Συνθεση για ελεγχομενη διεγερση των ωοθηκων
MY180745A (en) Silicone hydrogel lenses with relatively-long thermal stability
PH12015502816B1 (en) Stable liquid formulation of etelcalcetide (amg 416)
MX2020012356A (es) Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes.
BR112015018001A2 (pt) laminação retrorrefletiva tendo elementos de canto cúbico deformados
MX2020001223A (es) Proteinas de fusion tatk-cdkl5, composiciones, formulaciones y uso de estas.
WO2014200997A3 (en) Method for preparing three-dimensional, organotypic cell cultures and uses thereof
EP3448884C0 (en) Engineered mammalian cells for production of recombinant proteins
CL2016002358A1 (es) Aumento de la expresión de proteína recombinante con cobre.
WO2016007424A3 (en) Zwitterionic hydrogels for delivery of biomolecules
CL2014002410A1 (es) Método para la producción de proteínas recombinantes en glándula mamaria de mamíferos mediante la transformación del epítelio glandular mamario con vectores adenoasociados.

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.