CA2931219A1 - Piperidine compounds having multimodal activity against pain - Google Patents

Piperidine compounds having multimodal activity against pain Download PDF

Info

Publication number
CA2931219A1
CA2931219A1 CA2931219A CA2931219A CA2931219A1 CA 2931219 A1 CA2931219 A1 CA 2931219A1 CA 2931219 A CA2931219 A CA 2931219A CA 2931219 A CA2931219 A CA 2931219A CA 2931219 A1 CA2931219 A1 CA 2931219A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
methyl
phenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2931219A
Other languages
English (en)
French (fr)
Inventor
Felix Cuevas Cordobes
Carmen ALMANSA-ROSALES
Eva Maria AYET GALCERA
Maria Teresa SERAFINI CABANES
Monica Garcia Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of CA2931219A1 publication Critical patent/CA2931219A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2931219A 2013-12-20 2014-12-19 Piperidine compounds having multimodal activity against pain Abandoned CA2931219A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13384005 2013-12-20
EP13384005.8 2013-12-20
PCT/EP2014/078811 WO2015091988A1 (en) 2013-12-20 2014-12-19 Piperidine compounds having multimodal activity against pain

Publications (1)

Publication Number Publication Date
CA2931219A1 true CA2931219A1 (en) 2015-06-25

Family

ID=49998041

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2931219A Abandoned CA2931219A1 (en) 2013-12-20 2014-12-19 Piperidine compounds having multimodal activity against pain

Country Status (8)

Country Link
US (1) US9902711B2 (enExample)
EP (1) EP3083595B1 (enExample)
JP (1) JP6498672B2 (enExample)
CN (1) CN105829297B (enExample)
CA (1) CA2931219A1 (enExample)
ES (1) ES2806408T3 (enExample)
MX (1) MX2016006603A (enExample)
WO (1) WO2015091988A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017502010A (ja) 2013-12-20 2017-01-19 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対して多重モードの活性を有するピペリジン誘導体
CN107001368B (zh) * 2014-11-21 2019-05-31 埃斯特韦制药股份公司 具有多重模式抗疼痛活性的1,9-二氮杂螺环十一烷化合物
MX2018000419A (es) * 2015-07-29 2018-05-07 Esteve Labor Dr Derivados de amida sustituida que tienen actividad multimodal contra el dolor.
TW201734009A (zh) * 2015-10-23 2017-10-01 艾斯提夫博士實驗股份有限公司 具有抗疼痛活性的經取代的□啉衍生物
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2083476B (en) * 1980-09-12 1984-02-08 Wyeth John & Brother Ltd Heterocyclic compounds
ZA871335B (en) * 1986-02-27 1987-09-30 Duphar Int Res New aryl-substituted(n-piperidinyl)methyl-and(n-piperazinyl)-methylazoles having antipsychotic properties
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
DE4321366A1 (de) * 1993-06-26 1995-01-05 Merck Patent Gmbh Piperidine und Piperazine
EP1053235A1 (en) * 1998-02-03 2000-11-22 American Home Products Corporation Oxazole derivatives as serotonin-1a receptor agonists
US6248755B1 (en) * 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
JP3893960B2 (ja) * 2001-01-12 2007-03-14 トヨタ自動車株式会社 動力伝達装置
EP1648881A1 (en) * 2003-07-04 2006-04-26 GlaxoSmithKline S.p.A. Substituted indole ligands for the orl-1 receptor
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
WO2008157844A1 (en) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
WO2011072275A2 (en) * 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
WO2011137331A2 (en) * 2010-04-30 2011-11-03 Kinentia Biosciences Llc 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
JP2013189395A (ja) * 2012-03-14 2013-09-26 Dainippon Sumitomo Pharma Co Ltd ジヒドロピロロピラジノン誘導体
JP2016028016A (ja) * 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途

Also Published As

Publication number Publication date
WO2015091988A1 (en) 2015-06-25
JP6498672B2 (ja) 2019-04-10
US20170001979A1 (en) 2017-01-05
JP2016540793A (ja) 2016-12-28
CN105829297A (zh) 2016-08-03
EP3083595B1 (en) 2020-05-27
MX2016006603A (es) 2016-09-06
EP3083595A1 (en) 2016-10-26
ES2806408T3 (es) 2021-02-17
CN105829297B (zh) 2019-08-09
US9902711B2 (en) 2018-02-27

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210309

FZDE Discontinued

Effective date: 20210309