CA2923963C - Nouveaux processus et systeme pour separation magnetique - Google Patents

Nouveaux processus et systeme pour separation magnetique Download PDF

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Publication number
CA2923963C
CA2923963C CA2923963A CA2923963A CA2923963C CA 2923963 C CA2923963 C CA 2923963C CA 2923963 A CA2923963 A CA 2923963A CA 2923963 A CA2923963 A CA 2923963A CA 2923963 C CA2923963 C CA 2923963C
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Canada
Prior art keywords
magnetic
particles
magnetic particles
molecules
derivatives
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CA2923963A
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English (en)
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CA2923963A1 (fr
Inventor
Sven Oscarsson
Kristofer Eriksson
Per-Olov ERIKSSON
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LAB-ON-A-BEAD AB
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LAB-ON-A-BEAD AB
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3861—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36 using an external stimulus
    • B01D15/3885—Using electrical or magnetic means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28009—Magnetic properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un processus pour séparation à grande échelle de molécules, comprenant les étapes consistant à : fournir des particules poreuses magnétiques ayant une affinité pour lesdites molécules à séparer ; mélanger lesdites particules poreuses magnétiques avec une solution contenant lesdites molécules ; amener ledit mélange en contact avec un dispositif de séparation magnétique comprenant un canal d'écoulement et au moins un élément magnétique ; retirer ledit au moins un élément magnétique et collecter les particules poreuses magnétiques portant lesdites molécules ; séparer lesdites molécules à partir desdites particules poreuses magnétiques ; obtenir une fraction concentrée desdites molécules ; et faire recirculer les particules poreuses magnétiques. L'invention concerne également un système pour réaliser ce processus.
CA2923963A 2013-09-09 2014-09-09 Nouveaux processus et systeme pour separation magnetique Active CA2923963C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1351038-3 2013-09-09
SE1351038 2013-09-09
SE1450206 2014-02-20
SE1450206-6 2014-02-20
PCT/SE2014/051036 WO2015034428A1 (fr) 2013-09-09 2014-09-09 Nouveaux processus et système pour séparation magnétique

Publications (2)

Publication Number Publication Date
CA2923963A1 CA2923963A1 (fr) 2015-03-12
CA2923963C true CA2923963C (fr) 2022-06-14

Family

ID=52628752

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2923963A Active CA2923963C (fr) 2013-09-09 2014-09-09 Nouveaux processus et systeme pour separation magnetique

Country Status (6)

Country Link
US (1) US20160184737A1 (fr)
EP (1) EP3043903B1 (fr)
JP (1) JP6525341B2 (fr)
CN (1) CN105792926B (fr)
CA (1) CA2923963C (fr)
WO (1) WO2015034428A1 (fr)

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* Cited by examiner, † Cited by third party
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AU2016271497B2 (en) 2015-06-05 2022-03-03 Novartis Ag Flow-through paramagnetic particle-based cell separation and paramagnetic particle removal
CN106216334A (zh) * 2016-08-10 2016-12-14 新奥科技发展有限公司 除垢方法和除垢系统
US10329554B2 (en) 2016-11-07 2019-06-25 Wavesense, Inc. System and method for sequestering substances in bulk liquids
US11846635B2 (en) * 2016-12-28 2023-12-19 Cytiva Sweden Ab Magnetic immunoglobulin-binding particles
CN108333343A (zh) * 2017-01-19 2018-07-27 深圳市新产业生物医学工程股份有限公司 免疫磁性复合物、其制备方法、包括其的抗原捕获剂、试剂盒、系统及应用
CN111226116B (zh) * 2017-06-19 2024-05-03 微球实验公司 组合式分离
JP7396777B2 (ja) * 2018-09-28 2023-12-12 オクタン バイオテック インコーポレーテッド 磁気分離
CN109395875B (zh) * 2018-12-11 2023-10-20 苏州英赛斯智能科技有限公司 一种磁珠分离机构、装置以及磁珠分离方法
US20220389053A1 (en) * 2019-10-05 2022-12-08 Lab-On-A-Bead Ab Purification process based on magnetic beads
US20210260600A1 (en) * 2020-02-01 2021-08-26 Sunil Mehta Automated device and method to purify biomaterials from a mixture by using magnetic particles and disposable product-contact materials
JP2022086721A (ja) * 2020-11-30 2022-06-09 マイクロ波化学株式会社 磁性ナノ粒子の洗浄分離方法及び洗浄分離システム

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US4861705A (en) * 1983-01-31 1989-08-29 Yeda Research And Development Company, Ltd. Method for removing components of biological fluids
US5110624A (en) * 1989-09-19 1992-05-05 The University Of Colorado Foundation, Inc. Method for preparing magnetizable porous particles
US6036857A (en) * 1998-02-20 2000-03-14 Florida State University Research Foundation, Inc. Apparatus for continuous magnetic separation of components from a mixture
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
GB0116358D0 (en) * 2001-07-04 2001-08-29 Genovision As Preparation of polymer particles
EP1638662A2 (fr) * 2003-06-27 2006-03-29 Dynal Biotech ASA Conjuges de particules magnetiques polymeriques et acide aspartique carboxymethyle
GB0406015D0 (en) * 2004-03-17 2004-04-21 Dynal Biotech Asa Improvements in magnetic polymer particles
CA2839092C (fr) * 2004-08-03 2018-04-03 Becton, Dickinson And Company Utilisation d'un materiau magnetique permettant de proceder a l'isoleme t de composes et le fractionnement d'echantillons constitues de plusieu s parties
JP2006341212A (ja) * 2005-06-10 2006-12-21 Magnetec Japan Ltd 磁性異物類除去清掃装置
US7547473B2 (en) * 2005-11-18 2009-06-16 National Cheng Kung University Magnetic nanoparticles and method for producing the same
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Also Published As

Publication number Publication date
US20160184737A1 (en) 2016-06-30
EP3043903B1 (fr) 2022-04-06
EP3043903A1 (fr) 2016-07-20
EP3043903A4 (fr) 2017-05-17
JP2016536132A (ja) 2016-11-24
CN105792926B (zh) 2018-06-22
CA2923963A1 (fr) 2015-03-12
CN105792926A (zh) 2016-07-20
WO2015034428A1 (fr) 2015-03-12
JP6525341B2 (ja) 2019-06-05

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Effective date: 20190906