CA2918096C - Method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid - Google Patents

Method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid Download PDF

Info

Publication number
CA2918096C
CA2918096C CA2918096A CA2918096A CA2918096C CA 2918096 C CA2918096 C CA 2918096C CA 2918096 A CA2918096 A CA 2918096A CA 2918096 A CA2918096 A CA 2918096A CA 2918096 C CA2918096 C CA 2918096C
Authority
CA
Canada
Prior art keywords
compound
reaction
ethoxy
equation
route
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2918096A
Other languages
English (en)
French (fr)
Other versions
CA2918096A1 (en
Inventor
Yue Zhang
Tingting Liu
Yifeng YU
Zhenhua SHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hebei University of Science and Technology
Original Assignee
Hebei University of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hebei University of Science and Technology filed Critical Hebei University of Science and Technology
Publication of CA2918096A1 publication Critical patent/CA2918096A1/en
Application granted granted Critical
Publication of CA2918096C publication Critical patent/CA2918096C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2918096A 2014-03-13 2014-05-04 Method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid Active CA2918096C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410091929.XA CN103880679B (zh) 2014-03-13 2014-03-13 3-乙氧基-4-乙氧羰基苯乙酸的合成方法
CN201410091929.X 2014-03-13
PCT/CN2014/000458 WO2015135096A1 (zh) 2014-03-13 2014-05-04 3-乙氧基-4-乙氧羰基苯乙酸的合成方法

Publications (2)

Publication Number Publication Date
CA2918096A1 CA2918096A1 (en) 2015-09-17
CA2918096C true CA2918096C (en) 2018-08-14

Family

ID=50949849

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2918096A Active CA2918096C (en) 2014-03-13 2014-05-04 Method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid

Country Status (3)

Country Link
CN (1) CN103880679B (zh)
CA (1) CA2918096C (zh)
WO (1) WO2015135096A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106316837B (zh) * 2015-06-24 2020-04-24 浙江九洲药业股份有限公司 一种取代苯乙酸衍生物的制备方法
CN110483292A (zh) * 2019-08-29 2019-11-22 杭州中美华东制药有限公司 一种瑞格列奈关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215040C (zh) * 2002-11-12 2005-08-17 上海三维制药有限公司 4－羧甲基－2－乙氧基苯甲酸乙酯的合成方法
US20040249188A1 (en) * 2003-05-29 2004-12-09 Dr. Reddy's Laboratories Limited Process for the preparation of 3-ethoxy-4-(alkoxy carbonyl)-phenyl acetic acid. (an intermediate of repaglinide)
CN100368375C (zh) * 2005-12-31 2008-02-13 浙江海翔药业股份有限公司 3-烷氧基-4-烷氧羰基苯乙酸酯及3-烷氧基-4-烷氧羰基苯乙酸的合成方法
CN101891621B (zh) * 2010-07-15 2015-05-13 启东市沪东化工有限公司 3-乙氧基-4-乙氧羰基苯乙酸的合成方法
WO2013058824A1 (en) * 2011-04-07 2013-04-25 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
CN102311352B (zh) * 2011-07-11 2013-10-16 上海应用技术学院 一种2-甲氧基-4-甲基苄胺的合成方法

Also Published As

Publication number Publication date
WO2015135096A1 (zh) 2015-09-17
CN103880679A (zh) 2014-06-25
CN103880679B (zh) 2015-02-11
CA2918096A1 (en) 2015-09-17

Similar Documents

Publication Publication Date Title
EP2504322B1 (de) Verfahren zur herstellung 5,5-disubstituierter 4,5-dihydroisoxazol-3-thiocarboxamidin-salze
DE2524929C3 (de) 2-Hydroxyäthylidencyanessigsäureanilide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Mittel
CA2918096C (en) Method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid
EP1819659B1 (de) Verfahren zur herstellung von phthalsauredichlorid
DE4020052A1 (de) Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
EP2072497A1 (de) Verfahren zum Herstellen von 2-Fluoracyl-3-amino-acrylsäure-Derivaten
US4209445A (en) Process for the preparation of piperonylidenecrotonic acid amides
DE2823938A1 (de) Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
CN110283103A (zh) 一种碱催化的脱羧胺化制备氨基酸酯/酰胺的方法
EP1340747A1 (de) Verfahren zur Herstellung von 2-Halogenalkyl-Nicotinsäurealkylester
EP0002735A2 (de) Verfahren zur Herstellung von Piperonylidencrotonsäureamiden
Sarel et al. Communications-Base-Catalyzed Rearrangement of α-Haloacetanilide into α-Anilinoacid Derivatives
DE2708304C2 (de) Verfahren zur Herstellung von Halogenacetalen ausgehend von Estern
EP0909749A1 (de) Verfahren zur Herstellung von Pentafluorpentanol
CN105198835B (zh) 苯并噻唑‑2‑甲酸的合成工艺
DE2240398A1 (de) Verfahren zur herstellung von arylessigsaeurealkylestern
JPH05279330A (ja) アルキル環状アミド誘導体の製造法
CN106458928A (zh) 含醚性氧原子的全氟烷基取代嘧啶环化合物及其制造方法
DE2240399A1 (de) Verfahren zur herstellung von arylessigsaeurealkylestern
Barlow et al. Preparations, structures and reactions of mono-alkene alkyne complexes of rhodium (I): The crystal structures of acetylacetonato (ethylene)(hexafluorobut-2-yne) rhodium (I) and acetylacetonato (cyclo-octene)(hexafluorobut-2-yne) rhodium (I)
EP0508217B1 (de) Verfahren zur Herstellung von 2-Chlorpyridinen
DE191547C (zh)
CN115710238A (zh) 一种β-羰基氨基甲酸酯类化合物、其制备方法及应用
DE1670001C3 (de) Verfahren zur Herstellung von Indol-3-essigsäurederivaten
JP5715456B2 (ja) アルキルスルホニルカルバメートの製造方法

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160112