CA2915474A1 - Use of nk-1 receptor antagonist serlopitant in pruritus - Google Patents
Use of nk-1 receptor antagonist serlopitant in pruritus Download PDFInfo
- Publication number
- CA2915474A1 CA2915474A1 CA2915474A CA2915474A CA2915474A1 CA 2915474 A1 CA2915474 A1 CA 2915474A1 CA 2915474 A CA2915474 A CA 2915474A CA 2915474 A CA2915474 A CA 2915474A CA 2915474 A1 CA2915474 A1 CA 2915474A1
- Authority
- CA
- Canada
- Prior art keywords
- serlopitant
- cream
- administered
- day
- ointment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- FLNYCRJBCNNHRH-OIYLJQICSA-N 3-[(3ar,4r,5s,7as)-5-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one Chemical compound C1([C@H]2[C@@H]3CN(C[C@H]3CC[C@@H]2O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C=2CCC(=O)C=2)=CC=C(F)C=C1 FLNYCRJBCNNHRH-OIYLJQICSA-N 0.000 title claims abstract description 160
- 229950011343 serlopitant Drugs 0.000 title claims abstract description 152
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 126
- 229940044551 receptor antagonist Drugs 0.000 title abstract description 17
- 239000002464 receptor antagonist Substances 0.000 title abstract description 17
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title abstract description 12
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 64
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 37
- 238000011282 treatment Methods 0.000 claims abstract description 33
- 239000003908 antipruritic agent Substances 0.000 claims abstract description 25
- 230000007958 sleep Effects 0.000 claims abstract description 17
- 239000006071 cream Substances 0.000 claims description 67
- 239000002674 ointment Substances 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 39
- 238000012423 maintenance Methods 0.000 claims description 34
- 238000011068 loading method Methods 0.000 claims description 29
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- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 9
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- 230000001624 sedative effect Effects 0.000 claims description 8
- POPFMWWJOGLOIF-XWCQMRHXSA-N Flurandrenolide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O POPFMWWJOGLOIF-XWCQMRHXSA-N 0.000 claims description 7
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- WBGKWQHBNHJJPZ-LECWWXJVSA-N desonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O WBGKWQHBNHJJPZ-LECWWXJVSA-N 0.000 claims description 7
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims description 7
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 6
- 206010037083 Prurigo Diseases 0.000 claims description 6
- 239000001961 anticonvulsive agent Substances 0.000 claims description 6
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 6
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- BMCQMVFGOVHVNG-TUFAYURCSA-N cortisol 17-butyrate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O BMCQMVFGOVHVNG-TUFAYURCSA-N 0.000 claims description 5
- FZCHYNWYXKICIO-FZNHGJLXSA-N cortisol 17-valerate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O FZCHYNWYXKICIO-FZNHGJLXSA-N 0.000 claims description 5
- 229960004511 fludroxycortide Drugs 0.000 claims description 5
- 229960000289 fluticasone propionate Drugs 0.000 claims description 5
- 229960002870 gabapentin Drugs 0.000 claims description 5
- 208000019423 liver disease Diseases 0.000 claims description 5
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims description 5
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims description 4
- 206010019663 Hepatic failure Diseases 0.000 claims description 4
- FBRAWBYQGRLCEK-RJFLZJKCSA-N [(8s,9s,10s,13s,14r,16r,17r)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-yl] butanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@]2(F)[C@@H]1[C@H]1C[C@@H](C)[C@@](C(=O)CCl)(OC(=O)CCC)[C@@]1(C)CC2=O FBRAWBYQGRLCEK-RJFLZJKCSA-N 0.000 claims description 4
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- 229940018869 cutivate Drugs 0.000 claims description 4
- 229960002475 halometasone Drugs 0.000 claims description 4
- GGXMRPUKBWXVHE-MIHLVHIWSA-N halometasone Chemical compound C1([C@@H](F)C2)=CC(=O)C(Cl)=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O GGXMRPUKBWXVHE-MIHLVHIWSA-N 0.000 claims description 4
- 239000002955 immunomodulating agent Substances 0.000 claims description 4
- 229940121354 immunomodulator Drugs 0.000 claims description 4
- 231100000835 liver failure Toxicity 0.000 claims description 4
- 208000007903 liver failure Diseases 0.000 claims description 4
- 229960001233 pregabalin Drugs 0.000 claims description 4
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 4
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 3
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 claims description 3
- MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 claims description 3
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 3
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims description 3
- KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 claims description 3
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 3
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 3
- 229960003792 acrivastine Drugs 0.000 claims description 3
- PWACSDKDOHSSQD-IUTFFREVSA-N acrivastine Chemical compound C1=CC(C)=CC=C1C(\C=1N=C(\C=C\C(O)=O)C=CC=1)=C/CN1CCCC1 PWACSDKDOHSSQD-IUTFFREVSA-N 0.000 claims description 3
- 229960003099 amcinonide Drugs 0.000 claims description 3
- ILKJAFIWWBXGDU-MOGDOJJUSA-N amcinonide Chemical compound O([C@@]1([C@H](O2)C[C@@H]3[C@@]1(C[C@H](O)[C@]1(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]13)C)C(=O)COC(=O)C)C12CCCC1 ILKJAFIWWBXGDU-MOGDOJJUSA-N 0.000 claims description 3
- 229960004574 azelastine Drugs 0.000 claims description 3
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 claims description 3
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- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims description 3
- OFYVIGTWSQPCLF-NWDGAFQWSA-N bicifadine Chemical compound C1=CC(C)=CC=C1[C@@]1(CNC2)[C@H]2C1 OFYVIGTWSQPCLF-NWDGAFQWSA-N 0.000 claims description 3
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- ACCMWZWAEFYUGZ-UHFFFAOYSA-N bilastine Chemical compound N=1C2=CC=CC=C2N(CCOCC)C=1C(CC1)CCN1CCC1=CC=C(C(C)(C)C(O)=O)C=C1 ACCMWZWAEFYUGZ-UHFFFAOYSA-N 0.000 claims description 3
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 3
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- MJJALKDDGIKVBE-UHFFFAOYSA-N ebastine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)CCCN1CCC(OC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MJJALKDDGIKVBE-UHFFFAOYSA-N 0.000 claims description 3
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- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims description 3
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims description 3
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- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims description 3
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- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims description 3
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- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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Landscapes
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838784P | 2013-06-24 | 2013-06-24 | |
| US13/925,509 US8906951B1 (en) | 2013-06-24 | 2013-06-24 | Use of NK-1 receptor antagonists in pruritus |
| US13/925,509 | 2013-06-24 | ||
| US61/838,784 | 2013-06-24 | ||
| PCT/US2014/043811 WO2014209962A1 (en) | 2013-06-24 | 2014-06-24 | Use of nk-1 receptor antagonist serlopitant in pruritus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2915474A1 true CA2915474A1 (en) | 2014-12-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2915474A Abandoned CA2915474A1 (en) | 2013-06-24 | 2014-06-24 | Use of nk-1 receptor antagonist serlopitant in pruritus |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP3013336A1 (ko) |
| JP (2) | JP2016523260A (ko) |
| KR (1) | KR20160023692A (ko) |
| CN (1) | CN105473138A (ko) |
| AU (2) | AU2014302694B2 (ko) |
| BR (1) | BR112015031724A2 (ko) |
| CA (1) | CA2915474A1 (ko) |
| HK (1) | HK1223820A1 (ko) |
| IL (1) | IL243189A0 (ko) |
| MX (2) | MX366728B (ko) |
| PH (2) | PH12015502777A1 (ko) |
| RU (1) | RU2666219C2 (ko) |
| WO (1) | WO2014209962A1 (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| JP6741655B2 (ja) | 2014-09-19 | 2020-08-19 | ヘロン セラピューティクス， インコーポレイテッドＨｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | アプレピタントのエマルジョン製剤 |
| KR20230173743A (ko) * | 2015-03-04 | 2023-12-27 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피턴트에 의한 치료 방법 |
| US9974742B2 (en) | 2016-02-01 | 2018-05-22 | Heron Therapeutics, Inc. | Emulsion formulations of an NK-1 receptor antagonist and uses thereof |
| AU2016391046A1 (en) * | 2016-02-01 | 2018-08-16 | Heron Therapeutics, Inc. | Emulsion comprising an NK-1 receptor antagonist |
| KR20190039936A (ko) * | 2016-06-29 | 2019-04-16 | 멘로 쎄라퓨틱스 인크. | 다양한 소양증성 병태를 치료하기 위한 뉴로키닌-1 길항제의 용도 |
| AU2018331267B2 (en) * | 2017-09-13 | 2024-03-07 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| WO2019088926A1 (en) * | 2017-11-01 | 2019-05-09 | National University Of Singapore | Use of serotonergic drugs to treat virus-induced thrombocytopenia |
| WO2019152232A1 (en) * | 2018-01-31 | 2019-08-08 | Twi Pharmaceuticals, Inc. | Topical formulations comprising tofacitinib |
| CN115015440A (zh) * | 2022-07-08 | 2022-09-06 | 江苏杜瑞制药有限公司 | 一种生物样品中纳呋拉啡的检测方法 |
| CN117503699A (zh) * | 2023-12-08 | 2024-02-06 | 斯坦德医药研发(江苏)有限公司 | 阿瑞匹坦口服液制剂及制剂制造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100565A1 (en) | 2001-09-21 | 2003-05-29 | Boehringer Ingelheim International Gmbh | Method for the treatment or prevention of atopic dermatitis |
| CN100582093C (zh) * | 2004-01-27 | 2010-01-20 | 默克公司 | 氢异二氢吲哚速激肽受体拮抗剂 |
| AR047439A1 (es) * | 2004-01-27 | 2006-01-18 | Merck & Co Inc | Antagonistas del receptor hidroisoindolina taquiquinina |
| WO2007008564A1 (en) | 2005-07-11 | 2007-01-18 | Merck & Co., Inc. | Process for making hydroisoindoline tachykinin receptor antagonists |
| AU2006302562A1 (en) | 2005-10-04 | 2007-04-19 | Merck Sharp & Dohme Corp. | Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence |
| WO2007146224A2 (en) | 2006-06-12 | 2007-12-21 | Merck & Co., Inc. | Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence |
| US20100209496A1 (en) | 2006-09-06 | 2010-08-19 | Eleni Dokou | Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide |
| WO2008054690A2 (en) | 2006-11-02 | 2008-05-08 | Merck & Co., Inc. | Polymorphs of a hydroisoindoline tachykinin receptor antagonist |
| US20100113469A1 (en) | 2007-03-29 | 2010-05-06 | Merck & Co., Inc. | Combination therapy for the treatment-of lower urinary tract symptoms |
| RU2370265C1 (ru) * | 2008-03-04 | 2009-10-20 | Лев Давидович Раснецов | Гель, обладающий противовоспалительным и противоаллергическим действием |
-
2014
- 2014-06-24 JP JP2016521898A patent/JP2016523260A/ja not_active Ceased
- 2014-06-24 MX MX2015017763A patent/MX366728B/es active IP Right Grant
- 2014-06-24 BR BR112015031724A patent/BR112015031724A2/pt not_active Application Discontinuation
- 2014-06-24 AU AU2014302694A patent/AU2014302694B2/en not_active Ceased
- 2014-06-24 EP EP14744671.0A patent/EP3013336A1/en not_active Withdrawn
- 2014-06-24 WO PCT/US2014/043811 patent/WO2014209962A1/en active Application Filing
- 2014-06-24 CN CN201480035219.3A patent/CN105473138A/zh active Pending
- 2014-06-24 CA CA2915474A patent/CA2915474A1/en not_active Abandoned
- 2014-06-24 RU RU2015154037A patent/RU2666219C2/ru active
- 2014-06-24 KR KR1020157035921A patent/KR20160023692A/ko not_active Application Discontinuation
-
2015
- 2015-12-14 PH PH12015502777A patent/PH12015502777A1/en unknown
- 2015-12-17 IL IL243189A patent/IL243189A0/en unknown
- 2015-12-18 MX MX2019008643A patent/MX2019008643A/es unknown
-
2016
- 2016-09-23 HK HK16111172.9A patent/HK1223820A1/zh unknown
-
2019
- 2019-05-07 JP JP2019087897A patent/JP2019142960A/ja active Pending
-
2020
- 2020-01-14 AU AU2020200259A patent/AU2020200259A1/en not_active Abandoned
- 2020-02-04 PH PH12020500255A patent/PH12020500255A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020200259A1 (en) | 2020-02-06 |
| JP2019142960A (ja) | 2019-08-29 |
| MX366728B (es) | 2019-07-22 |
| MX2019008643A (es) | 2019-09-10 |
| AU2014302694B2 (en) | 2019-10-17 |
| RU2666219C2 (ru) | 2018-09-06 |
| BR112015031724A2 (pt) | 2017-07-25 |
| PH12020500255A1 (en) | 2021-02-22 |
| RU2015154037A (ru) | 2017-07-28 |
| EP3013336A1 (en) | 2016-05-04 |
| PH12015502777A1 (en) | 2016-03-21 |
| HK1223820A1 (zh) | 2017-08-11 |
| MX2015017763A (es) | 2016-06-21 |
| IL243189A0 (en) | 2016-02-29 |
| JP2016523260A (ja) | 2016-08-08 |
| KR20160023692A (ko) | 2016-03-03 |
| CN105473138A (zh) | 2016-04-06 |
| AU2014302694A1 (en) | 2016-01-07 |
| WO2014209962A1 (en) | 2014-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190621 |
|
| FZDE | Discontinued |
Effective date: 20220107 |