CA2915005C - Use of eribulin and lenvatinib as combination therapy for treatment of cancer - Google Patents

Use of eribulin and lenvatinib as combination therapy for treatment of cancer Download PDF

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Publication number
CA2915005C
CA2915005C CA2915005A CA2915005A CA2915005C CA 2915005 C CA2915005 C CA 2915005C CA 2915005 A CA2915005 A CA 2915005A CA 2915005 A CA2915005 A CA 2915005A CA 2915005 C CA2915005 C CA 2915005C
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CA
Canada
Prior art keywords
cancer
pharmaceutically acceptable
acceptable salt
eribulin
lenvatinib
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Active
Application number
CA2915005A
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English (en)
French (fr)
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CA2915005A1 (en
Inventor
Kenichi Nomoto
Jiayi Wu
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Publication of CA2915005A1 publication Critical patent/CA2915005A1/en
Application granted granted Critical
Publication of CA2915005C publication Critical patent/CA2915005C/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
CA2915005A 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer Active CA2915005C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361839542P 2013-06-26 2013-06-26
US61/839,542 2013-06-26
PCT/JP2014/067723 WO2014208774A1 (en) 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer

Publications (2)

Publication Number Publication Date
CA2915005A1 CA2915005A1 (en) 2014-12-31
CA2915005C true CA2915005C (en) 2021-12-28

Family

ID=51210708

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2915005A Active CA2915005C (en) 2013-06-26 2014-06-26 Use of eribulin and lenvatinib as combination therapy for treatment of cancer

Country Status (12)

Country Link
US (1) US9549922B2 (cg-RX-API-DMAC7.html)
EP (1) EP3013335B1 (cg-RX-API-DMAC7.html)
JP (1) JP6404242B2 (cg-RX-API-DMAC7.html)
KR (1) KR102265952B1 (cg-RX-API-DMAC7.html)
CN (1) CN105338977B (cg-RX-API-DMAC7.html)
AU (1) AU2014299699B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015029386B1 (cg-RX-API-DMAC7.html)
CA (1) CA2915005C (cg-RX-API-DMAC7.html)
ES (1) ES2705698T3 (cg-RX-API-DMAC7.html)
IL (1) IL242386B (cg-RX-API-DMAC7.html)
RU (1) RU2672585C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014208774A1 (cg-RX-API-DMAC7.html)

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SMT202200367T1 (it) 2014-08-28 2022-11-18 Eisai R&D Man Co Ltd Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso
CA2976325C (en) 2015-02-25 2023-07-04 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
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KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
AU2016309356B2 (en) 2015-08-20 2021-06-24 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
EP3449921B1 (en) * 2016-04-28 2023-05-31 Eisai R&D Management Co., Ltd. Eribulin for inhibiting tumor growth
CN105832732A (zh) * 2016-05-30 2016-08-10 青岛云天生物技术有限公司 一种用于胃癌治疗的药物组合物及其应用
WO2018124847A1 (ko) * 2017-01-02 2018-07-05 연성정밀화학(주) 에리불린 메실산염의 제조 중간체 및 그의 제조방법
ES2971448T3 (es) * 2017-02-08 2024-06-05 Eisai R&D Man Co Ltd Composición farmacéutica para el tratamiento de tumores
CA3061888A1 (en) 2017-05-16 2018-11-22 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
EP3713565A1 (en) 2017-11-20 2020-09-30 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
CN107973804B (zh) * 2017-11-29 2020-07-03 戊言医药科技(上海)有限公司 艾瑞布林中间体的合成方法
KR20250073570A (ko) * 2018-01-10 2025-05-27 에자이 알앤드디 매니지먼트 가부시키가이샤 간세포성 암종의 치료를 위한 조합 요법
CN109793736A (zh) * 2019-01-31 2019-05-24 徐州医科大学 一种乐伐替尼在制备自然杀伤细胞激动剂中的应用
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN114028394A (zh) * 2021-05-21 2022-02-11 中山大学 低剂量仑伐替尼在制备治疗肝癌的药物中的用途
JP2024531220A (ja) * 2021-08-10 2024-08-29 メルク・シャープ・アンド・ドーム・エルエルシー Tigitアンタゴニスト、pd-1アンタゴニスト、及びレンバチニブを含む治療薬の組み合わせ

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US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
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KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
AU2003211594A1 (en) 2002-03-05 2003-09-16 Eisai Co., Ltd. Antitumor agent comprising combination of sulfonamide-containing heterocyclic compound with angiogenesis inhibitor
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JP5226304B2 (ja) * 2004-06-03 2013-07-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンb類似体の調製用中間体
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KR101573026B1 (ko) * 2007-07-25 2015-11-30 에자이 알앤드디 매니지먼트 가부시키가이샤 암 치료에서 이용하기 위한 멀티키나아제 억제제
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BR112012018232B8 (pt) 2010-01-26 2023-01-10 Eisai R&D Man Co Ltd Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina
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Also Published As

Publication number Publication date
BR112015029386B1 (pt) 2023-11-14
US20150005343A1 (en) 2015-01-01
ES2705698T3 (es) 2019-03-26
BR112015029386A2 (pt) 2017-07-25
KR102265952B1 (ko) 2021-06-16
RU2016102158A (ru) 2017-07-31
EP3013335A1 (en) 2016-05-04
BR112015029386A8 (pt) 2020-03-17
JP2016528162A (ja) 2016-09-15
JP6404242B2 (ja) 2018-10-10
US9549922B2 (en) 2017-01-24
RU2672585C2 (ru) 2018-11-16
IL242386B (en) 2019-06-30
AU2014299699A1 (en) 2015-12-10
EP3013335B1 (en) 2018-11-07
CN105338977B (zh) 2018-10-16
KR20160023816A (ko) 2016-03-03
WO2014208774A1 (en) 2014-12-31
CN105338977A (zh) 2016-02-17
AU2014299699B2 (en) 2019-10-10
CA2915005A1 (en) 2014-12-31

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Effective date: 20190524