CA2906771A1 - Compositions and methods for treating fungal and bacterial pathogens - Google Patents
Compositions and methods for treating fungal and bacterial pathogensInfo
- Publication number
- CA2906771A1 CA2906771A1 CA2906771A CA2906771A CA2906771A1 CA 2906771 A1 CA2906771 A1 CA 2906771A1 CA 2906771 A CA2906771 A CA 2906771A CA 2906771 A CA2906771 A CA 2906771A CA 2906771 A1 CA2906771 A1 CA 2906771A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- polypeptide
- amino acid
- acid sequence
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/165—Yeast isolates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/72—Candida
- C12R2001/725—Candida albicans
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
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- Epidemiology (AREA)
- Molecular Biology (AREA)
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- Biophysics (AREA)
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- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Virology (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201361789091P | 2013-03-15 | 2013-03-15 | |
| US61/789,091 | 2013-03-15 | ||
| PCT/US2014/028521 WO2014144211A2 (en) | 2013-03-15 | 2014-03-14 | Compositions and methods for treating fungal and bacterial pathogens |
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| CA2906771A1 true CA2906771A1 (en) | 2014-09-18 |
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| CA2906771A Abandoned CA2906771A1 (en) | 2013-03-15 | 2014-03-14 | Compositions and methods for treating fungal and bacterial pathogens |
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| EP (1) | EP2968497B1 (OSRAM) |
| JP (2) | JP6591961B2 (OSRAM) |
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| WO (1) | WO2014144211A2 (OSRAM) |
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| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| CN105407915A (zh) | 2013-03-15 | 2016-03-16 | 加州大学洛杉矶分校港口医学中心生物医学研究所 | 用于治疗真菌性和细菌性病原体的组合物和方法 |
| US10857216B2 (en) | 2016-03-09 | 2020-12-08 | Novadigm Therapeutics, Inc. | Methods and kits for use in preventing and treating vulvovaginal candidiasis |
| CN112203684A (zh) * | 2018-04-10 | 2021-01-08 | 海港医学中心洛杉矶生物医学研究所 | 耳念珠菌感染的治疗方法 |
| WO2020174366A1 (en) | 2019-02-28 | 2020-09-03 | Universidade Do Minho | Antisense oligomers for controlling candida albicans infections |
| US20220354935A1 (en) * | 2021-04-21 | 2022-11-10 | Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center | Vaccination against fungal epitopes to prevent inflammatory bowel diseases |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2964721D1 (en) | 1978-08-24 | 1983-03-17 | Nat Res Dev | Pasteurellosis vaccines |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5622939A (en) | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| WO1995031998A1 (en) | 1994-05-23 | 1995-11-30 | The Research & Development Institute, Inc. | Candida albicans adhesin as a vaccine |
| US5668263A (en) | 1994-12-16 | 1997-09-16 | Smithkline Beecham Corporation | Conserved yeast nucleic acid sequences |
| PT831897E (pt) | 1995-06-07 | 2001-07-31 | Pfizer | Vacinacao in ovo contra a coccidiose |
| AU3126097A (en) | 1996-05-16 | 1997-12-05 | The Texas A & M University System | Collagen binding protein compositions and methods of use |
| US6747137B1 (en) | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US6248329B1 (en) | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| US6703025B1 (en) | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
| US7067138B1 (en) | 1999-11-19 | 2006-06-27 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20060083750A1 (en) | 1999-11-19 | 2006-04-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20070077256A1 (en) | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US8541008B2 (en) | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| EP2196217A1 (en) | 2001-09-14 | 2010-06-16 | Cytos Biotechnology AG | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| CA2492823A1 (en) | 2001-09-14 | 2003-03-27 | Martin F. Bachmann | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| EP3269235B1 (en) | 2001-11-30 | 2022-01-26 | Amgen Fremont Inc. | Transgenic mice bearing human ig lambda light chain genes |
| CN101596312A (zh) | 2002-05-21 | 2009-12-09 | 先灵-普劳有限公司 | 孢子纲物种体外培养的方法及其用途 |
| US7241613B1 (en) * | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| WO2004043407A2 (en) | 2002-11-12 | 2004-05-27 | The Brigham And Women's Hospital, Inc. | Methods and products for treating staphylococcal infections |
| BRPI0416205A (pt) | 2003-11-21 | 2006-12-26 | Pfizer Prod Inc | uso de antibióticos como adjuvantes de vacina |
| WO2005060713A2 (en) | 2003-12-19 | 2005-07-07 | Inhibitex, Inc. | Method of inhibiting candida-related infections using donor selected or donor stimulated immunoglobulin compositions |
| GB0420466D0 (en) | 2004-09-14 | 2004-10-20 | Cassone Antonio | Anti-glucan antibodies |
| WO2006036817A2 (en) * | 2004-09-24 | 2006-04-06 | Microbia, Inc. | Fungal variants and uses thereof |
| CA2489194A1 (en) | 2004-12-03 | 2006-06-03 | Guilhem Janbon | Polypeptides involved in candida biofilm formation and uses thereof |
| WO2007126813A2 (en) * | 2006-03-29 | 2007-11-08 | Inhibitex, Inc. | Cross-reactive monoclonal antibodies recognizing als family proteins |
| MX2008013451A (es) | 2006-04-17 | 2008-10-30 | Schering Plough Ltd | Organismos clostridium atenuados recombinantes y vacuna. |
| WO2008147847A1 (en) | 2007-05-22 | 2008-12-04 | Baylor College Of Medicine | Immune complex vaccination as a strategy to enhance immunity in the elderly and other immune compromised populations |
| RU2525587C2 (ru) | 2008-05-29 | 2014-08-20 | Интервет Интернэшнл Б.В. | Вакцинная композиция для иммунизации животного против кокцидиоза и способ ее использования |
| US20100150942A1 (en) | 2008-12-03 | 2010-06-17 | Cantor Thomas L | Affinity purified human polyclonal antibodies and methods of making and using them |
| JP5395264B2 (ja) | 2009-06-22 | 2014-01-22 | ワイス・エルエルシー | 黄色ブドウ球菌（ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）抗原の免疫原性組成物 |
| RU2559537C2 (ru) * | 2009-07-03 | 2015-08-10 | Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер | Hyr1 в качестве мишени для активной и пассивной иммунизации против candida |
| HRP20181175T1 (hr) * | 2011-03-11 | 2018-09-21 | Vib Vzw | Molekule i postupci za inhibiciju i otkrivanje proteina |
| WO2012163533A1 (en) | 2011-06-01 | 2012-12-06 | Eth Zurich | T cell epitope of candida albicans |
| UA114286C2 (uk) * | 2011-07-22 | 2017-05-25 | Общєство С Огранічєнной Отвєтствєнностью "Новамєдіка" | Спосіб лікування staphylococcus aureus |
| BR112014005773A2 (pt) | 2011-09-14 | 2019-09-24 | Los Angeles Biomedical Res Inst At Harbor-Ucla Medical Center | composições derivadas de hyr1 e métodos of tratamento usando as mesmas |
| WO2014144024A1 (en) | 2013-03-15 | 2014-09-18 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Hyr1 compositions and methods for treating fungal and bacterial pathogens |
| WO2014144222A2 (en) | 2013-03-15 | 2014-09-18 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods of treating fungal and bacterial pathogens |
| CN105407915A (zh) | 2013-03-15 | 2016-03-16 | 加州大学洛杉矶分校港口医学中心生物医学研究所 | 用于治疗真菌性和细菌性病原体的组合物和方法 |
| GB201503812D0 (en) | 2015-03-06 | 2015-04-22 | Univ Aberdeen | Antibody molecules and uses thereof |
| US10857216B2 (en) | 2016-03-09 | 2020-12-08 | Novadigm Therapeutics, Inc. | Methods and kits for use in preventing and treating vulvovaginal candidiasis |
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2014
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| AU2014227748B2 (en) | 2019-02-14 |
| CN105407915A (zh) | 2016-03-16 |
| RU2015144090A (ru) | 2017-04-19 |
| MD20150098A2 (ro) | 2016-02-29 |
| BR112015022963A8 (pt) | 2018-01-16 |
| JP2019110918A (ja) | 2019-07-11 |
| EP2968497B1 (en) | 2020-08-12 |
| JP2016515516A (ja) | 2016-05-30 |
| JP6591961B2 (ja) | 2019-10-16 |
| EA030005B1 (ru) | 2018-06-29 |
| EP2968497A4 (en) | 2016-11-30 |
| MX2015012681A (es) | 2018-05-17 |
| US10130691B2 (en) | 2018-11-20 |
| AU2014227748A1 (en) | 2015-10-08 |
| RU2717306C2 (ru) | 2020-03-19 |
| EA201591808A1 (ru) | 2016-02-29 |
| WO2014144211A8 (en) | 2015-10-08 |
| WO2014144211A3 (en) | 2015-11-19 |
| US20190030141A1 (en) | 2019-01-31 |
| BR112015022963A2 (pt) | 2017-11-14 |
| US20160030534A1 (en) | 2016-02-04 |
| WO2014144211A2 (en) | 2014-09-18 |
| EP2968497A2 (en) | 2016-01-20 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20190325 |
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| FZDE | Discontinued |
Effective date: 20210831 |