CA2903473A1 - Histone demethylase inhibitors - Google Patents
Histone demethylase inhibitors Download PDFInfo
- Publication number
- CA2903473A1 CA2903473A1 CA2903473A CA2903473A CA2903473A1 CA 2903473 A1 CA2903473 A1 CA 2903473A1 CA 2903473 A CA2903473 A CA 2903473A CA 2903473 A CA2903473 A CA 2903473A CA 2903473 A1 CA2903473 A1 CA 2903473A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pyridine
- pyrrolo
- formula
- embodiment provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010074870 Histone Demethylases Proteins 0.000 title claims abstract description 22
- 102000008157 Histone Demethylases Human genes 0.000 title claims abstract description 22
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- 125000000217 alkyl group Chemical group 0.000 claims description 108
- 125000001072 heteroaryl group Chemical group 0.000 claims description 75
- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
- 125000003118 aryl group Chemical group 0.000 claims description 70
- 150000003839 salts Chemical class 0.000 claims description 46
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 29
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000003282 alkyl amino group Chemical group 0.000 claims description 16
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- 230000002401 inhibitory effect Effects 0.000 claims description 9
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778193P | 2013-03-12 | 2013-03-12 | |
| US61/778,193 | 2013-03-12 | ||
| PCT/US2014/023273 WO2014164708A1 (en) | 2013-03-12 | 2014-03-11 | Histone dementhylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2903473A1 true CA2903473A1 (en) | 2014-10-09 |
Family
ID=51658949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2903473A Abandoned CA2903473A1 (en) | 2013-03-12 | 2014-03-11 | Histone demethylase inhibitors |
Country Status (6)
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|---|---|
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| EP (1) | EP2968282B1 (OSRAM) |
| JP (1) | JP6320506B2 (OSRAM) |
| AU (1) | AU2014249050B2 (OSRAM) |
| CA (1) | CA2903473A1 (OSRAM) |
| WO (1) | WO2014164708A1 (OSRAM) |
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| CA2961580A1 (en) | 2014-09-17 | 2016-03-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| BR112017005511A2 (pt) | 2014-09-17 | 2018-08-14 | Celgene Quanticel Res Inc | inibidores da histona-desmetilase. |
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| WO2017161012A1 (en) * | 2016-03-15 | 2017-09-21 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
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| KR102658602B1 (ko) | 2018-10-31 | 2024-04-19 | 길리애드 사이언시즈, 인코포레이티드 | Hpk1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물 |
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| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| CA2390948A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
| PE20050206A1 (es) | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
| US7666898B2 (en) * | 2005-11-03 | 2010-02-23 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors |
| US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| MY148893A (en) * | 2006-12-04 | 2013-06-14 | Novartis Ag | Combination of an hdac inhibitor and an antimetabolite |
| ES2369596T3 (es) * | 2007-05-04 | 2011-12-02 | Astrazeneca Ab | Derivados de amino-tiazolil-pirimidina y su uso para el tratamiento del cáncer. |
| CA2721218C (en) * | 2008-04-15 | 2015-03-24 | Pharmacyclics, Inc. | Selective inhibitors of histone deacetylase |
| DE102008052943A1 (de) * | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | Azaindolderivate |
| JP2012107001A (ja) | 2010-10-22 | 2012-06-07 | Shionogi & Co Ltd | インドールアミド化合物を含有する医薬 |
| SG2014009609A (en) * | 2011-08-15 | 2014-05-29 | Univ Utah Res Found | Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors |
| US9988377B2 (en) * | 2011-08-24 | 2018-06-05 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders |
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| EP2934145B1 (en) | 2012-12-19 | 2017-11-15 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| EP2968282B1 (en) | 2013-03-12 | 2018-05-09 | Celgene Quanticel Research, Inc. | Histone dementhylase inhibitors |
| CA2961580A1 (en) | 2014-09-17 | 2016-03-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
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2014
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- 2014-03-11 AU AU2014249050A patent/AU2014249050B2/en not_active Ceased
- 2014-03-11 JP JP2016501190A patent/JP6320506B2/ja not_active Expired - Fee Related
- 2014-03-11 CA CA2903473A patent/CA2903473A1/en not_active Abandoned
- 2014-03-11 WO PCT/US2014/023273 patent/WO2014164708A1/en not_active Ceased
- 2014-03-11 US US14/774,329 patent/US9738637B2/en active Active
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2017
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- 2017-12-14 US US15/842,700 patent/US10174026B2/en active Active
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2018
- 2018-11-27 US US16/202,072 patent/US10494369B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014164708A1 (en) | 2014-10-09 |
| EP2968282A1 (en) | 2016-01-20 |
| JP2016516699A (ja) | 2016-06-09 |
| US20160194315A1 (en) | 2016-07-07 |
| EP2968282A4 (en) | 2016-08-24 |
| US10174026B2 (en) | 2019-01-08 |
| US9738637B2 (en) | 2017-08-22 |
| US20170313702A1 (en) | 2017-11-02 |
| US9873697B2 (en) | 2018-01-23 |
| US20180105521A1 (en) | 2018-04-19 |
| US20190092771A1 (en) | 2019-03-28 |
| AU2014249050B2 (en) | 2017-10-05 |
| US10494369B2 (en) | 2019-12-03 |
| JP6320506B2 (ja) | 2018-05-09 |
| AU2014249050A1 (en) | 2015-09-17 |
| EP2968282B1 (en) | 2018-05-09 |
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