CA2902360A1 - Phototherapeutic device, method and use - Google Patents
Phototherapeutic device, method and use Download PDFInfo
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- CA2902360A1 CA2902360A1 CA2902360A CA2902360A CA2902360A1 CA 2902360 A1 CA2902360 A1 CA 2902360A1 CA 2902360 A CA2902360 A CA 2902360A CA 2902360 A CA2902360 A CA 2902360A CA 2902360 A1 CA2902360 A1 CA 2902360A1
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- light
- minutes
- peak wavelength
- lamp
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B45/00—Circuit arrangements for operating light-emitting diodes [LED]
- H05B45/20—Controlling the colour of the light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
Landscapes
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- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pathology (AREA)
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- Radiation-Therapy Devices (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771466P | 2013-03-01 | 2013-03-01 | |
| US61/771,466 | 2013-03-01 | ||
| US201361786140P | 2013-03-14 | 2013-03-14 | |
| US61/786,140 | 2013-03-14 | ||
| US14/194,216 | 2014-02-28 | ||
| PCT/CA2014/000161 WO2014131115A1 (en) | 2013-03-01 | 2014-02-28 | Phototherapeutic device, method and use |
| US14/194,216 US20140303547A1 (en) | 2013-03-01 | 2014-02-28 | Phototherapeutic device, method and use |
Publications (1)
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| CA2902360A1 true CA2902360A1 (en) | 2014-09-04 |
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|---|---|---|---|
| CA2902360A Abandoned CA2902360A1 (en) | 2013-03-01 | 2014-02-28 | Phototherapeutic device, method and use |
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Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2352488T (lt) | 2008-11-07 | 2017-05-25 | Klox Technologies Inc. | Oksidacinė fotoaktyvuojama odos atjauninimo kompozicija, apimanti hialurono rūgštį, gliukozaminą arba alantoiną |
| SMT201700575T1 (it) | 2009-07-17 | 2018-01-11 | Klox Tech Inc | Composizione orale antibatterica |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| WO2015000058A1 (en) | 2013-07-03 | 2015-01-08 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
| AU2015210594B2 (en) | 2014-02-03 | 2019-10-31 | Zerigo Health, Inc. | Systems and methods for phototherapy |
| AU2015240385B2 (en) | 2014-04-01 | 2019-02-28 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| BR112016028040A2 (pt) | 2014-05-29 | 2017-08-22 | New Skin Therapies Llc D/B/A/ Nst Consulting Llc | Dispositivo de tratamento para tratar uma unha, leito ungueal e tecido circundante, uso de um dispositivo para tratamento não térmico, dispositivo de esterilização e kit de tratamento para tratar um fungo |
| US11358002B2 (en) | 2014-05-29 | 2022-06-14 | Raymond R. Blanche | Method and apparatus for non-thermal nail, foot, and hand fungus treatment |
| WO2016011233A1 (en) * | 2014-07-16 | 2016-01-21 | LiteProducts LLC | Device and method for inactivating pathogens using visible light |
| GB2545375B (en) | 2014-09-18 | 2018-10-10 | Xenex Disinfection Services Llc | Room and area disinfection utilizing pulsed light with modulated power flux and light systems with visible light compensation between pulses |
| WO2016061380A1 (en) | 2014-10-15 | 2016-04-21 | Xenex Disinfection Services, Llc | Pre-doffing disinfection systems and methods |
| JP2018500468A (ja) | 2014-10-31 | 2018-01-11 | クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | 光活性性の繊維および織物媒体 |
| EP3782572A1 (en) | 2015-04-10 | 2021-02-24 | Zerigo Health, Inc. | Phototherapy light engine |
| EP3325927A4 (en) | 2015-07-24 | 2019-04-03 | Clarify Medical, Inc. | SYSTEMS AND METHOD FOR CONTROLLING LIGHT THERAPY |
| US20170056684A1 (en) * | 2015-08-31 | 2017-03-02 | Sasson Elihue Moulavi | Lipolysis exercise device. |
| EP3851161A1 (en) | 2015-10-15 | 2021-07-21 | DUSA Pharmaceuticals, Inc. | Adjustable illuminator for photodynamic therapy and diagnosis |
| US10603508B2 (en) | 2015-10-15 | 2020-03-31 | Dusa Pharmaceuticals, Inc. | Adjustable illuminators and methods for photodynamic therapy and diagnosis |
| EP3402523A4 (en) | 2016-01-11 | 2019-07-24 | Francesco Bellini | BIOPHOTONIC COMPOSITIONS FOR THE TREATMENT OF PYODERMA |
| EP3202359B1 (en) * | 2016-02-02 | 2021-08-25 | Braun GmbH | Skin treatment device |
| ES2893295T3 (es) * | 2016-02-02 | 2022-02-08 | Braun Gmbh | Dispositivo para el tratamiento de la piel |
| CA3025009C (en) * | 2016-05-26 | 2022-07-26 | San Diego State University Research Foundation | Photoeradication of microorganisms with pulsed purple or blue light |
| US10981017B2 (en) | 2016-05-26 | 2021-04-20 | San Diego State University Research Foundation | Photoeradication of microorganisms with pulsed purple or blue light |
| KR101877320B1 (ko) * | 2016-07-15 | 2018-07-11 | 주식회사 이루다 | 레이저 및 고주파를 이용한 한방 뜸 및 침 장치 |
| JP7261994B2 (ja) * | 2016-08-10 | 2023-04-21 | パナソニックＩｐマネジメント株式会社 | 抗菌方法及び抗菌装置 |
| US10898600B2 (en) * | 2016-08-10 | 2021-01-26 | Panasonic Intellectual Property Management Co., Ltd. | Disinfecting method and disinfecting apparatus |
| CN106328795A (zh) * | 2016-10-21 | 2017-01-11 | 电子科技大学 | 一种医用光疗的pc‑LEDs灯 |
| CA3057840A1 (en) * | 2017-04-14 | 2018-10-18 | Dusa Pharmaceuticals, Inc. | Adjustable illuminators and methods for photodynamic therapy and diagnosis |
| US11590248B2 (en) * | 2017-10-30 | 2023-02-28 | Hubbell Lighting, Inc. | Pulsing high intensity narrow spectrum light |
| CN107812321A (zh) * | 2017-11-01 | 2018-03-20 | 深圳市汇健医疗工程有限公司 | 一种icu人造太阳系统 |
| US20200405858A1 (en) * | 2017-11-17 | 2020-12-31 | Klox Technologies Limited | Modulation of biophotonic regimens |
| TWI821233B (zh) * | 2017-12-29 | 2023-11-11 | 美商西勒斯股份有限公司 | 用於處理生物流體之方法、藉由該方法製備之病原體去活生物流體、及用於處理生物流體之系統 |
| US10357567B1 (en) | 2018-01-12 | 2019-07-23 | Dusa Pharmaceuticals, Inc. | Methods for photodynamic therapy |
| KR102001512B1 (ko) * | 2018-03-21 | 2019-10-21 | 계명대학교 산학협력단 | 욕창의 진단 및 치료가 동시에 가능한 바이오 포토닉스 장치 |
| US11241374B2 (en) | 2018-06-28 | 2022-02-08 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating skin conditions using light and glucosamine hydrochloride |
| US12048853B2 (en) * | 2018-08-14 | 2024-07-30 | Seoul Viosys Co., Ltd. | Light irradiation apparatus |
| US10967197B2 (en) | 2018-08-29 | 2021-04-06 | Azulite, Inc. | Phototherapy devices and methods for treating truncal acne and scars |
| DE202018105021U1 (de) | 2018-09-03 | 2018-09-19 | Rüdiger Schloo | Kabelloses Lichttherapiegerät für die Dusche |
| US10478635B1 (en) | 2018-10-22 | 2019-11-19 | Joovv, Inc. | Photobiomodulation therapy systems and methods |
| US11458328B2 (en) | 2018-10-22 | 2022-10-04 | Joovv, Inc. | Photobiomodulation therapy device accessories |
| US11280096B1 (en) * | 2018-10-31 | 2022-03-22 | Harry Bussey | Cushioning preform for flooring |
| US11992698B2 (en) * | 2019-03-19 | 2024-05-28 | Seoul Viosys Co., Ltd. | Light irradiation device |
| RU2716617C1 (ru) * | 2019-04-17 | 2020-03-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации | Способ лечения пациентов псориазом в прогрессирующей стадии |
| RU2716616C1 (ru) * | 2019-04-17 | 2020-03-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации | Способ лечения пациентов с псориазом в прогрессирующей стадии |
| KR20240157773A (ko) | 2019-06-03 | 2024-11-01 | 쿨러 헤드스 케어 인코포레이티드 | 냉각 캡 어셈블리 및 냉각 유닛 |
| CA3143213A1 (en) | 2019-06-22 | 2020-12-30 | Cerus Corporation | Biological fluid treatment systems |
| WO2020264421A1 (en) | 2019-06-28 | 2020-12-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
| WO2021092570A1 (en) * | 2019-11-08 | 2021-05-14 | EcoSense Lighting, Inc. | Dynamic display lighting systems with bioactive lighting |
| US20230270896A1 (en) * | 2019-11-27 | 2023-08-31 | National University Of Singapore | System and method of eliminating microorganisms |
| KR102079094B1 (ko) * | 2019-12-03 | 2020-02-19 | 임현태 | 육각구조 광원 배치를 통해 조사밀도가 증가된 통증치료기 |
| US20230071297A1 (en) * | 2020-01-23 | 2023-03-09 | Klox Technologies Inc. | Polarized fluorescent light therapy system and method |
| US11529153B2 (en) | 2020-08-21 | 2022-12-20 | University Of Washington | Vaccine generation |
| WO2022040258A1 (en) | 2020-08-21 | 2022-02-24 | University Of Washington | Disinfection method and apparatus |
| US20220062461A1 (en) * | 2020-09-02 | 2022-03-03 | University Of Washington | Photosensitizer combination |
| US11425905B2 (en) | 2020-09-02 | 2022-08-30 | University Of Washington | Antimicrobial preventive netting |
| USD1047162S1 (en) | 2020-09-21 | 2024-10-15 | Joovv, Inc. | Photobiomodulation therapy device |
| USD1004789S1 (en) | 2020-09-21 | 2023-11-14 | Joovv, Inc. | Photobiomodulation therapy device |
| USD963873S1 (en) | 2020-09-21 | 2022-09-13 | Joovv, Inc. | Floor stand for a photobiomodulation therapy device |
| MX2023003795A (es) * | 2020-10-01 | 2023-06-01 | G Life | Dispositivo y metodo para aplicar fotobiomodulacion. |
| US12472374B2 (en) | 2020-10-15 | 2025-11-18 | Biofrontera Pharma Gmbh | Illumination device for photodynamic therapy, method for treating a skin disease and method for operating an illumination device |
| US11458220B2 (en) | 2020-11-12 | 2022-10-04 | Singletto Inc. | Microbial disinfection for personal protection equipment |
| CN112402808A (zh) * | 2020-11-18 | 2021-02-26 | 尹垚懿 | 一种寄生物灭活装置 |
| WO2022204610A1 (en) * | 2021-03-26 | 2022-09-29 | Lispiro Llc | Anticancer compositions and methods for using same |
| KR102624810B1 (ko) * | 2021-07-23 | 2024-01-15 | 현광철 | 광 조사 장치 및 그 제어 방법 |
| WO2023038984A1 (en) * | 2021-09-08 | 2023-03-16 | Into Technologies Inc. | System and method for providing context-based light and/or auditory stimulus experience |
| US12359369B2 (en) | 2022-08-11 | 2025-07-15 | Singletto Inc. | Skin protection against microbial particles |
| WO2024038286A1 (en) | 2022-08-19 | 2024-02-22 | Aesthetic Technology Ltd | Phototherapy device for light emission |
| WO2025144369A1 (en) * | 2023-12-29 | 2025-07-03 | Ege Üni̇versi̇tesi̇ İdari̇ Ve Mali̇ İşlerdai̇re Bşk. | A non-invasive phototherapy device for the treatment of respiratory distress syndrome in infants and adults and for surfactant production |
| WO2025164817A1 (ko) * | 2024-01-30 | 2025-08-07 | 엘지전자 주식회사 | 피부 치료용 전자 장치 및 그 제어 방법 |
| AT528267A1 (de) * | 2024-05-08 | 2025-11-15 | Luminous Labs Gmbh | Vorrichtungen, verfahren und systeme zum erzeugen einer kontrollierten lichtemission |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8182473B2 (en) * | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
| US6887260B1 (en) * | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
| US6663659B2 (en) * | 2000-01-13 | 2003-12-16 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
| US20030216795A1 (en) * | 1999-07-07 | 2003-11-20 | Yoram Harth | Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders |
| GB2360459B (en) * | 2000-03-23 | 2002-08-07 | Photo Therapeutics Ltd | Therapeutic light source and method |
| US20030009158A1 (en) * | 2001-07-09 | 2003-01-09 | Perricone Nicholas V. | Skin treatments using blue and violet light |
| US20040147984A1 (en) * | 2001-11-29 | 2004-07-29 | Palomar Medical Technologies, Inc. | Methods and apparatus for delivering low power optical treatments |
| US7081128B2 (en) * | 2002-03-04 | 2006-07-25 | Hart Barry M | Phototherapy device and method of use |
| US7201766B2 (en) * | 2002-07-03 | 2007-04-10 | Life Support Technologies, Inc. | Methods and apparatus for light therapy |
| US20080091250A1 (en) * | 2002-09-26 | 2008-04-17 | Lumiport, Llc | Light therapy desk lamp |
| US7931028B2 (en) * | 2003-08-26 | 2011-04-26 | Jay Harvey H | Skin injury or damage prevention method using optical radiation |
| US20040218387A1 (en) * | 2003-03-18 | 2004-11-04 | Robert Gerlach | LED lighting arrays, fixtures and systems and method for determining human color perception |
| CA2457214A1 (en) * | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
| US20080125835A1 (en) * | 2006-02-02 | 2008-05-29 | Richard Laurent | Method and apparatus for light therapy |
| US8246611B2 (en) * | 2006-06-14 | 2012-08-21 | Candela Corporation | Treatment of skin by spatial modulation of thermal heating |
| CA2696857A1 (en) * | 2007-08-20 | 2009-02-26 | Universite Laval | Artificial light apparatus and its use for influencing a condition in a subject |
| US9079022B2 (en) * | 2007-09-27 | 2015-07-14 | Led Intellectual Properties, Llc | LED based phototherapy device for photo-rejuvenation of cells |
| JP4740934B2 (ja) * | 2007-12-07 | 2011-08-03 | シャープ株式会社 | 照明装置 |
| EP2373249B1 (en) * | 2008-12-30 | 2018-04-11 | Ultradent Products, Inc. | Dental curing light having unibody design that acts as a heat sink |
| KR20110118646A (ko) * | 2009-01-05 | 2011-10-31 | 플렉스트로닉스, 인크 | 유기 발광 다이오드 광선치료 조명 시스템 |
| US8574490B2 (en) * | 2009-03-31 | 2013-11-05 | Bactriblue, Ltd. | Methods and apparatus for reducing count of infectious agents in intravenous access systems |
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2014
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- 2014-02-28 KR KR1020157026777A patent/KR20150143456A/ko not_active Withdrawn
- 2014-02-28 RU RU2015141708A patent/RU2015141708A/ru not_active Application Discontinuation
- 2014-02-28 CA CA2902360A patent/CA2902360A1/en not_active Abandoned
- 2014-02-28 US US14/194,216 patent/US20140303547A1/en not_active Abandoned
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2015
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| WO2014131115A1 (en) | 2014-09-04 |
| US20140303547A1 (en) | 2014-10-09 |
| BR112015020804A2 (pt) | 2017-07-18 |
| RU2015141708A (ru) | 2017-04-06 |
| KR20150143456A (ko) | 2015-12-23 |
| JP2016511672A (ja) | 2016-04-21 |
| IL240783A0 (en) | 2015-10-29 |
| ZA201506216B (en) | 2019-04-24 |
| AU2014223268A1 (en) | 2015-09-17 |
| MX2015011296A (es) | 2016-04-04 |
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