CA2897925C - Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications - Google Patents

Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications Download PDF

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Publication number
CA2897925C
CA2897925C CA2897925A CA2897925A CA2897925C CA 2897925 C CA2897925 C CA 2897925C CA 2897925 A CA2897925 A CA 2897925A CA 2897925 A CA2897925 A CA 2897925A CA 2897925 C CA2897925 C CA 2897925C
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zone
insulin
controller
day
night
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English (en)
French (fr)
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CA2897925A1 (en
Inventor
Francis J. Doyle, Iii
Dassau EYAL
Ravi L. Gondhalekar
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2897925A 2013-01-14 2014-01-14 Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications Active CA2897925C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361751942P 2013-01-14 2013-01-14
US61/751,942 2013-01-14
PCT/US2014/011378 WO2014110541A1 (en) 2013-01-14 2014-01-14 Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type i diabetes applications

Publications (2)

Publication Number Publication Date
CA2897925A1 CA2897925A1 (en) 2014-07-17
CA2897925C true CA2897925C (en) 2017-05-30

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CA2897925A Active CA2897925C (en) 2013-01-14 2014-01-14 Daily periodic target-zone modulation in the model predictive control problem for artificial pancreas for type 1 diabetes applications

Country Status (8)

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US (1) US10507284B2 (enExample)
EP (1) EP2943150B1 (enExample)
JP (1) JP6810989B2 (enExample)
KR (1) KR102212020B1 (enExample)
CN (1) CN105050539B (enExample)
AU (1) AU2014205123B2 (enExample)
CA (1) CA2897925C (enExample)
WO (1) WO2014110541A1 (enExample)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8417311B2 (en) 2008-09-12 2013-04-09 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
WO2012058694A2 (en) 2010-10-31 2012-05-03 Trustees Of Boston University Blood glucose control system
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
AU2015211258A1 (en) 2014-01-31 2016-08-11 Trustees Of Boston University Offline glucose control based on preceding periods
CN106714874B (zh) 2014-08-06 2019-10-08 加利福尼亚大学董事会 用于控制应用的滚动时域状态初始化器
DE102015000845A1 (de) * 2015-01-27 2016-07-28 W.O.M. World Of Medicine Gmbh Verfahren und Vorrichtung zur Regelung der Temperatur des Gasstroms bei medizintechnischen Vorrichtungen
AU2016219961B2 (en) 2015-02-18 2020-07-02 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
WO2017027459A1 (en) 2015-08-07 2017-02-16 Trustees Of Boston University Glucose control system with automatic adaptation of glucose target
WO2017070553A1 (en) * 2015-10-21 2017-04-27 University Of Virginia Patent Foundation System, method and computer readable medium for dynamical tracking of the risk for hypoglycemia in type 1 and type 2 diabetes
CN108883227B (zh) * 2016-01-12 2022-10-25 哈佛大学校董委员会 使用过去的预测的用于人工胰腺的预测控制模型
HK1257246A1 (zh) 2016-01-13 2019-10-18 Bigfoot Biomedical, Inc. 糖尿病管理系统的用户界面
HK1256995A1 (zh) 2016-01-14 2019-10-11 Bigfoot Biomedical, Inc. 药物输送设备、系统和方法中的阻塞解决方案
US10307538B2 (en) 2016-01-14 2019-06-04 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
EP3411109A4 (en) 2016-02-05 2019-07-10 Animas Corporation VISUALIZATION AND ANALYSIS TOOL FOR A DRUG DELIVERY SYSTEM
WO2017192397A1 (en) 2016-05-02 2017-11-09 Dexcom, Inc. System and method for providing alerts optimized for a user
US12383166B2 (en) 2016-05-23 2025-08-12 Insulet Corporation Insulin delivery system and methods with risk-based set points
US11883630B2 (en) 2016-07-06 2024-01-30 President And Fellows Of Harvard College Event-triggered model predictive control for embedded artificial pancreas systems
WO2018058041A1 (en) 2016-09-23 2018-03-29 Insulet Corporation Fluid delivery device with sensor
US11096624B2 (en) 2016-12-12 2021-08-24 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and systems
US10881793B2 (en) 2017-01-13 2021-01-05 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US10758675B2 (en) 2017-01-13 2020-09-01 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US11027063B2 (en) 2017-01-13 2021-06-08 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
EP3568860B1 (en) 2017-01-13 2025-12-10 Insulet Corporation Insulin delivery methods, systems and devices
US10500334B2 (en) 2017-01-13 2019-12-10 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US11497851B2 (en) * 2017-03-31 2022-11-15 Lifescan Ip Holdings, Llc Maintaining maximum dosing limits for closed loop insulin management systems
US11147920B2 (en) 2017-04-18 2021-10-19 Lifescan Ip Holdings, Llc Diabetes management system with automatic basal and manual bolus insulin control
CN116531603A (zh) 2017-05-05 2023-08-04 伊莱利利公司 生理葡萄糖的闭环控制
US12161463B2 (en) 2017-06-09 2024-12-10 President And Fellows Of Harvard College Prevention of post-bariatric hypoglycemia using a novel glucose prediction algorithm and mini-dose stable glucagon
EP3438858A1 (en) 2017-08-02 2019-02-06 Diabeloop Closed-loop blood glucose control systems and methods
JP7133625B2 (ja) 2017-12-21 2022-09-08 イーライ リリー アンド カンパニー 生理的グルコースの閉ループ制御
AU2019217879B2 (en) 2018-02-09 2023-12-21 Dexcom, Inc. System and method for decision support
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
US11158413B2 (en) 2018-04-23 2021-10-26 Medtronic Minimed, Inc. Personalized closed loop medication delivery system that utilizes a digital twin of the patient
US11147919B2 (en) 2018-04-23 2021-10-19 Medtronic Minimed, Inc. Methodology to recommend and implement adjustments to a fluid infusion device of a medication delivery system
US11565043B2 (en) 2018-05-04 2023-01-31 Insulet Corporation Safety constraints for a control algorithm based drug delivery system
US12128212B2 (en) 2018-06-19 2024-10-29 President And Fellows Of Harvard College Adaptive zone model predictive control with a glucose and velocity dependent dynamic cost function for an artificial pancreas
CA3103479A1 (en) 2018-06-22 2019-12-26 Eli Lilly And Company Insulin and pramlintide delivery systems, methods, and devices
US11547799B2 (en) 2018-09-20 2023-01-10 Medtronic Minimed, Inc. Patient day planning systems and methods
CN112789070A (zh) 2018-09-28 2021-05-11 英赛罗公司 人造胰腺系统的活动模式
US11565039B2 (en) 2018-10-11 2023-01-31 Insulet Corporation Event detection for drug delivery system
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11986629B2 (en) * 2019-06-11 2024-05-21 Medtronic Minimed, Inc. Personalized closed loop optimization systems and methods
US11957876B2 (en) 2019-07-16 2024-04-16 Beta Bionics, Inc. Glucose control system with automated backup therapy protocol generation
JP7657428B2 (ja) 2019-07-16 2025-04-07 ベータ バイオニクス,インコーポレイテッド 血糖制御システム
CA3146965C (en) 2019-07-16 2025-07-08 Beta Bionics, Inc. BLOOD SUGAR REGULATION SYSTEM
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
EP4069082B1 (en) 2019-12-06 2024-06-05 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
AU2021206190A1 (en) 2020-01-06 2022-08-18 Insulet Corporation Prediction of meal and/or exercise events based on persistent residuals
EP4100958A1 (en) 2020-02-03 2022-12-14 Insulet Corporation Use of fuzzy logic in predicting user behavior affecting blood glucose concentration
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US12495994B2 (en) 2020-02-20 2025-12-16 Insulet Corporation Meal bolus subcategories in model based insulin therapy
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
CN111710009B (zh) * 2020-05-29 2023-06-23 北京百度网讯科技有限公司 人流密度的生成方法、装置、电子设备以及存储介质
US12121700B2 (en) 2020-07-22 2024-10-22 Insulet Corporation Open-loop insulin delivery basal parameters based on insulin delivery records
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
US12128215B2 (en) 2020-09-30 2024-10-29 Insulet Corporation Drug delivery device with integrated optical-based glucose monitor
WO2022072618A1 (en) 2020-09-30 2022-04-07 Insulet Corporation Secure wireless communications between a glucose monitor and other devices
KR102521085B1 (ko) * 2020-10-30 2023-04-12 이오플로우(주) 인슐린 패치를 포함하는 인공췌장 제어 방법 및 그 장치
US11160925B1 (en) 2021-01-29 2021-11-02 Insulet Corporation Automatic drug delivery system for delivery of a GLP-1 therapeutic
US20220273874A1 (en) * 2021-02-24 2022-09-01 University Of Virginia Patent Foundation Method and system of fully-automated artificial pancreas control for counteracting postprandial hyperglycemia
US12431229B2 (en) 2021-03-10 2025-09-30 Insulet Corporation Medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
US12465686B2 (en) 2021-03-25 2025-11-11 Beta Bionics, Inc. Emergency medicament dose control
US12496398B2 (en) 2021-05-28 2025-12-16 Insulet Corporation Threshold based automatic glucose control response
US12406760B2 (en) 2021-06-07 2025-09-02 Insulet Corporation Exercise safety prediction based on physiological conditions
US12514980B2 (en) 2021-06-30 2026-01-06 Insulet Corporation Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase
US12521486B2 (en) 2021-07-16 2026-01-13 Insulet Corporation Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems
US11738144B2 (en) 2021-09-27 2023-08-29 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery
WO2024147928A1 (en) 2023-01-06 2024-07-11 Insulet Corporation Automatically or manually initiated meal bolus delivery with subsequent automatic safety constraint relaxation
CN119480135B (zh) * 2024-11-08 2025-10-10 北京理工大学 基于未知外源输入估计的餐后长时间窗血糖态势预测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8152789B2 (en) * 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US6740072B2 (en) * 2001-09-07 2004-05-25 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US7591801B2 (en) * 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
WO2006124716A2 (en) 2005-05-13 2006-11-23 Trustees Of Boston University Fully automated control system for type 1 diabetes
US9056165B2 (en) * 2006-09-06 2015-06-16 Medtronic Minimed, Inc. Intelligent therapy recommendation algorithm and method of using the same
US20080234943A1 (en) * 2007-03-20 2008-09-25 Pinaki Ray Computer program for diabetes management
US20100145262A1 (en) * 2007-05-03 2010-06-10 Novo Nordisk A/S Safety system for insulin delivery advisory algorithms
JP2010530279A (ja) * 2007-06-21 2010-09-09 メディンゴ・リミテッド 低血糖を防止するための装置および方法
JP2010531707A (ja) 2007-06-25 2010-09-30 メディンゴ・リミテッド 適合された基礎インスリン送達システム
CA2738389C (en) 2008-09-15 2017-01-17 Deka Products Limited Partnership Systems and methods for fluid delivery
US8062249B2 (en) * 2009-03-31 2011-11-22 Abbott Diabetes Care Inc. Overnight closed-loop insulin delivery with model predictive control and glucose measurement error model
EP2628115B1 (en) * 2010-10-12 2015-06-03 The Regents of The University of California Insulin delivery device
US9486578B2 (en) * 2012-12-07 2016-11-08 Animas Corporation Method and system for tuning a closed-loop controller for an artificial pancreas

Also Published As

Publication number Publication date
AU2014205123B2 (en) 2018-08-16
KR20150108860A (ko) 2015-09-30
WO2014110541A1 (en) 2014-07-17
EP2943150A1 (en) 2015-11-18
KR102212020B1 (ko) 2021-02-05
CN105050539A (zh) 2015-11-11
CA2897925A1 (en) 2014-07-17
JP2016504119A (ja) 2016-02-12
AU2014205123A1 (en) 2015-07-30
US10507284B2 (en) 2019-12-17
US20140200559A1 (en) 2014-07-17
EP2943150A4 (en) 2016-10-26
EP2943150B1 (en) 2018-12-05
CN105050539B (zh) 2018-05-18
JP6810989B2 (ja) 2021-01-13

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