CA2894548C - Anthracycline formulations - Google Patents
Anthracycline formulations Download PDFInfo
- Publication number
- CA2894548C CA2894548C CA2894548A CA2894548A CA2894548C CA 2894548 C CA2894548 C CA 2894548C CA 2894548 A CA2894548 A CA 2894548A CA 2894548 A CA2894548 A CA 2894548A CA 2894548 C CA2894548 C CA 2894548C
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- CA
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- Prior art keywords
- reconstituted formulation
- anthracycline compound
- emch
- doxo
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- Prior art date
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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| PCT/US2013/075002 WO2014093815A1 (en) | 2012-12-13 | 2013-12-13 | Anthracycline formulations |
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| KR20210059035A (ko) * | 2013-06-05 | 2021-05-24 | 싸이트알엑스 코포레이션 | 암 치료용 세포독성제 |
| RU2018106934A (ru) | 2015-08-25 | 2019-09-26 | Нантомикс, Ллс | Системы и способы высокоточного определения вариантов |
| US11071812B2 (en) * | 2016-05-31 | 2021-07-27 | Penumbra, Inc. | Methods and apparatus for extracting doxorubicin from blood and measuring doxorubicin in blood |
| JP7062754B2 (ja) | 2017-08-15 | 2022-05-06 | ナントセル，インコーポレイテッド | ｈａＮＫセツキシマブ併用及び方法 |
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| GB8426672D0 (en) | 1984-10-22 | 1984-11-28 | Erba Farmitalia | Pharmaceutical compositions |
| US5977082A (en) | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| JP2915252B2 (ja) | 1993-06-30 | 1999-07-05 | 明治製菓株式会社 | 溶解性が改善された製剤の製造法 |
| NZ336381A (en) * | 1996-12-30 | 2000-11-24 | Battelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| DE10012120A1 (de) | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| US6919370B2 (en) * | 2000-11-28 | 2005-07-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
| US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| GB0621973D0 (en) * | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| MX2009012370A (es) | 2007-05-16 | 2010-04-22 | Ktb Tumorforschungs Gmbh | Formulacion de antraciclina de baja viscosidad. |
| EP2216049A1 (en) * | 2009-02-06 | 2010-08-11 | Freie Universität Berlin | Drug conjugates with polyglycerols |
| CA2740317A1 (en) * | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
| EP2931042B1 (en) * | 2012-12-13 | 2021-04-28 | CytRx Corporation | Anthracycline formulations |
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2013
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- 2013-12-13 CA CA2894548A patent/CA2894548C/en active Active
- 2013-12-13 AU AU2013359048A patent/AU2013359048A1/en not_active Abandoned
- 2013-12-13 US US14/651,898 patent/US20150342975A1/en not_active Abandoned
- 2013-12-13 JP JP2015547985A patent/JP6433913B2/ja active Active
- 2013-12-13 EP EP21169873.3A patent/EP3915369A1/en active Pending
- 2013-12-13 WO PCT/US2013/075002 patent/WO2014093815A1/en not_active Ceased
- 2013-12-13 DK DK13863251.8T patent/DK2931042T3/da active
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2017
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2018
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2019
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2013359048A1 (en) | 2015-07-02 |
| JP2021120414A (ja) | 2021-08-19 |
| CA2894548A1 (en) | 2014-06-19 |
| JP2018165280A (ja) | 2018-10-25 |
| JP6433913B2 (ja) | 2018-12-05 |
| EP3915369A1 (en) | 2021-12-01 |
| JP2021120415A (ja) | 2021-08-19 |
| EP2931042A4 (en) | 2016-06-01 |
| US20150342975A1 (en) | 2015-12-03 |
| JP7213303B2 (ja) | 2023-01-26 |
| US20170340655A1 (en) | 2017-11-30 |
| US10328093B2 (en) | 2019-06-25 |
| EP2931042A1 (en) | 2015-10-21 |
| JP2019206583A (ja) | 2019-12-05 |
| HK1209973A1 (en) | 2016-04-15 |
| WO2014093815A1 (en) | 2014-06-19 |
| JP6833768B2 (ja) | 2021-02-24 |
| JP2016503026A (ja) | 2016-02-01 |
| EP2931042B1 (en) | 2021-04-28 |
| DK2931042T3 (da) | 2021-06-07 |
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