CA2894182A1 - Peptide therapeutics and methods for using same - Google Patents
Peptide therapeutics and methods for using same Download PDFInfo
- Publication number
- CA2894182A1 CA2894182A1 CA2894182A CA2894182A CA2894182A1 CA 2894182 A1 CA2894182 A1 CA 2894182A1 CA 2894182 A CA2894182 A CA 2894182A CA 2894182 A CA2894182 A CA 2894182A CA 2894182 A1 CA2894182 A1 CA 2894182A1
- Authority
- CA
- Canada
- Prior art keywords
- arg
- subject
- lys
- phe
- glp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734293P | 2012-12-06 | 2012-12-06 | |
| US61/734,293 | 2012-12-06 | ||
| PCT/US2013/036214 WO2014088631A1 (en) | 2012-12-06 | 2013-04-11 | Peptide therapeutics and methods for using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2894182A1 true CA2894182A1 (en) | 2014-06-12 |
Family
ID=49549068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2894182A Abandoned CA2894182A1 (en) | 2012-12-06 | 2013-04-11 | Peptide therapeutics and methods for using same |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20130303436A1 (enExample) |
| EP (3) | EP3287172A1 (enExample) |
| JP (3) | JP2016506391A (enExample) |
| CN (1) | CN104994912A (enExample) |
| CA (1) | CA2894182A1 (enExample) |
| HK (1) | HK1215934A1 (enExample) |
| WO (1) | WO2014088631A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4397314B1 (en) * | 2012-10-22 | 2025-12-03 | Stealth BioTherapeutics Inc. | Treatment of left ventricular remodeling |
| WO2015057315A1 (en) * | 2013-09-04 | 2015-04-23 | Kelly Joseph Michael Lawless | Methods and systems for the detection of disease |
| WO2015089316A1 (en) * | 2013-12-12 | 2015-06-18 | Cornell University | Methods for preventing and treating oral cancers |
| CA2933405A1 (en) * | 2013-12-13 | 2015-06-18 | Medimmune Limited | Protease-resistant peptides |
| EP3082838A4 (en) * | 2013-12-16 | 2017-07-26 | Cornell University | Methods and compositions for treating and preventing cognitive dysfunction |
| CN106132984B (zh) * | 2013-12-27 | 2020-12-08 | 康德生物医疗技术公司 | 药学相关的芳香族阳离子肽 |
| CN106459169A (zh) * | 2014-03-03 | 2017-02-22 | 康德生物医疗技术公司 | 药学上相关的芳香族阳离子肽 |
| WO2015183970A1 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including flavonoid and uses thereof |
| WO2015183984A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including tocopherol and uses thereof |
| WO2015183988A1 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including therapeutic small molecules and uses thereof |
| US10576124B2 (en) * | 2014-05-28 | 2020-03-03 | Stealth Biotherapeutics Corp | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| WO2015183963A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including redox-active parabenzoquinones and uses thereof |
| WO2015183985A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including naphthoquinones and uses thereof |
| US10627392B2 (en) | 2014-06-17 | 2020-04-21 | Stealth Biotherapeutics Corp | Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening |
| US10744178B2 (en) * | 2014-08-21 | 2020-08-18 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of disease |
| DK3006045T3 (en) * | 2014-10-07 | 2017-07-17 | Cyprumed Gmbh | Pharmaceutical formulations for oral administration of peptide or protein drugs |
| US12472157B2 (en) | 2014-11-07 | 2025-11-18 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa with n-acetylcysteine amide |
| US12667548B2 (en) | 2014-11-07 | 2026-06-30 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa and retinitis pigmentosa associated with Usher Syndrome with N-acetylcysteine amide |
| WO2016077422A1 (en) * | 2014-11-11 | 2016-05-19 | The Johns Hopkins University | Biomarkers useful in the treatment of subjects having retinits pigmentosa |
| US11268964B2 (en) * | 2014-11-11 | 2022-03-08 | The Johns Hopkins University | Biomarkers useful in the treatment of subjects having diseases of the eye |
| JP6854771B2 (ja) * | 2015-03-06 | 2021-04-07 | ステルス バイオセラピューティックス コープ | 薬学的に適切なペプチドを調製するための方法 |
| WO2016190852A1 (en) * | 2015-05-26 | 2016-12-01 | Stealth Peptides International, Inc. | Therapeutic compositions including chromanyl compounds, variants and analogues thereof, and uses thereof |
| WO2016195663A1 (en) * | 2015-06-02 | 2016-12-08 | Stealth Peptides International, Inc. | Therapeutic compositions including bpm 31510, variants and analogues thereof, and uses thereof |
| TWI726889B (zh) | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
| AU2016379403B2 (en) * | 2015-12-23 | 2020-03-12 | The Johns Hopkins University | Long-acting GLP-1r agonist as a therapy of neurological and neurodegenerative conditions |
| ES3057779T3 (en) | 2016-01-15 | 2026-03-04 | Childrens Medical Ct Corp | Therapeutic use of mitochondria and combined mitochondrial agents |
| US10870678B2 (en) | 2016-04-11 | 2020-12-22 | Arcuate Therapeutics, Inc. | Chiral peptides |
| CN105987839B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种edta-柠檬酸抗原修复液 |
| CN105987840B (zh) * | 2016-06-03 | 2018-09-28 | 浙江世纪康大医疗科技股份有限公司 | 一种柠檬酸抗原修复液 |
| WO2017210668A1 (en) * | 2016-06-03 | 2017-12-07 | Jt Pharmaceuticals, Inc. | Sustained release compositions of kappa-opioid receptor agonist |
| CN107042067B (zh) * | 2017-05-24 | 2019-11-08 | 天津大学 | 聚硅氧烷-金属有机框架材料杂化渗透蒸发复合膜及其制备与应用 |
| CA3067890A1 (en) * | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
| EP3443980A1 (en) * | 2017-08-15 | 2019-02-20 | Ciliocure Limited | Compound for the treatment of patients with leptin-resistant obesity, bardet-biedl syndrome and other ciliopathies |
| CA3079196C (en) | 2017-09-20 | 2021-05-18 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide and derivatives thereof |
| US12662449B2 (en) | 2017-09-20 | 2026-06-23 | Nacuity Pharmaceuticals, Inc. | Method for preparation of N-acetyl cysteine amide and derivatives thereof |
| US11091433B2 (en) | 2017-09-20 | 2021-08-17 | Nacuity Pharmaceutials, Inc. | Method for preparation of N-acetyl cysteine amide and derivatives thereof |
| US11548851B2 (en) | 2017-09-20 | 2023-01-10 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide and derivatives thereof |
| US20190135741A1 (en) | 2017-11-09 | 2019-05-09 | Nacuity Pharmaceuticals, Inc. | Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress |
| WO2019201333A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | Glp-1衍生物及其治疗用途 |
| AU2020206139A1 (en) | 2019-01-11 | 2021-07-29 | Nacuity Pharmaceuticals, Inc. | Treatment of age-related macular degeneration, glaucoma, and diabetic retinopathy with N-acetylicysteine amide (NACA) or 2R,2R')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (diNACA) |
| JP7631200B2 (ja) | 2019-01-11 | 2025-02-18 | ナキュイティ ファーマシューティカルズ, インク. | 放射線皮膚炎の予防及び治療、並びに皮膚ライトニング、皮膚ホワイトニング、並びに皮膚改善のためのn-アセチルシステインアミド(naca)及び(2r,2r’)-3,3’-ジスルファンジイルビス(2-アセトアミドプロパンアミド)(dinaca) |
| JP7638265B2 (ja) * | 2019-07-24 | 2025-03-03 | ステルス バイオセラピューティクス インコーポレイテッド | 神経変性疾患の治療におけるペプチド模倣化合物(r)-2-アミノ-n-((s)-l-(((s)-5-アミノ-l-(3-ベンジル-1,2,4-オキサジアゾール-5-イル)ペンチル)アミノ)-3-(4-ヒドロキシ-2,6-ジメチルフェニル)-i-オキソプロパン-2-イル)-5-グアニジノペンタンアミド |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
| KR102503914B1 (ko) * | 2020-09-01 | 2023-02-24 | 인제대학교 산학협력단 | 황반변성 세포모델의 제조방법 |
| US20230381281A1 (en) * | 2020-10-16 | 2023-11-30 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition comprising glucagon/glp-1/gip triple agonist or long-acting conjugate thereof for preventing or treating lupus-related diseases |
| KR20230125802A (ko) * | 2020-12-11 | 2023-08-29 | 아이피2아이피오 이노베이션스 리미티드 | 신규 화합물 |
| CN112618966B (zh) * | 2020-12-18 | 2023-07-28 | 北京宏强富瑞技术有限公司 | 一种多波长激光针刺仪 |
| CN113421648B (zh) * | 2021-06-21 | 2024-04-23 | 中国科学院北京基因组研究所(国家生物信息中心) | 一种用于预测射血分数保留型心衰风险的模型 |
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| CN116262134A (zh) * | 2021-12-15 | 2023-06-16 | 联邦生物科技(珠海横琴)有限公司 | 一种稳定的多剂量给药的glp-1受体激动剂的制剂及其制备方法和应用 |
| CN114480449A (zh) * | 2022-03-17 | 2022-05-13 | 天津医科大学总医院 | 布拉氏酵母菌CNCMI-745衍生蛋白Trx2及其在制备防治腹泻药物中的应用 |
| CN114949184A (zh) * | 2022-05-13 | 2022-08-30 | 华中科技大学同济医学院附属同济医院 | Glp-1代谢物在制备减轻急性肾损伤药物中的用途 |
| US20260165992A1 (en) * | 2024-12-13 | 2026-06-18 | Neuronasal, Inc. | Treatment of central nervous system diseases with n-acetylcysteine and glucagon-like peptide-1 receptor agonists |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| PT1263464E (pt) | 2000-03-09 | 2012-12-17 | Genzyme Corp | Utilização de anticorpos anti-tgf-beta antagonistas para tratar ou para prevenir a perda da função renal |
| CA2447008A1 (en) | 2001-04-05 | 2002-10-24 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| EP1411968B1 (en) * | 2001-07-31 | 2008-09-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Glp-1 exendin-4 peptide analogs and uses thereof |
| EP1701731A4 (en) | 2003-12-12 | 2009-08-05 | Einstein Coll Med | GLP-1 (9-36) METHOD AND COMPOSITIONS |
| US20090202497A1 (en) * | 2005-08-23 | 2009-08-13 | The General Hospital Corporation | Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes |
| US20100286029A1 (en) * | 2007-09-11 | 2010-11-11 | Dorian Bevec | Use of a peptide as a therapeutic agent |
| EP2712620A1 (en) * | 2008-02-07 | 2014-04-02 | Cornell University | Methods for Preventing or Treating Insulin Resistance |
| DK2344519T3 (en) | 2008-11-07 | 2017-01-23 | Massachusetts Gen Hospital | C-TERMINAL FRAGMENTS OF GLUCAGON SIMILAR PEPTID-1 (GLP-1) |
| CA2770688C (en) * | 2009-08-12 | 2018-06-05 | Cornell University | Methods for preventing or treating metabolic syndrome |
| EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| CN102614514B (zh) * | 2011-01-26 | 2014-12-10 | 王永祥 | Glp-1受体激动剂用于治疗疼痛 |
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- 2013-04-11 EP EP17184720.5A patent/EP3287172A1/en not_active Withdrawn
- 2013-04-11 CA CA2894182A patent/CA2894182A1/en not_active Abandoned
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| US20160101158A1 (en) | 2016-04-14 |
| JP2016506391A (ja) | 2016-03-03 |
| HK1215934A1 (zh) | 2016-09-30 |
| EP3459598A1 (en) | 2019-03-27 |
| US20180344814A1 (en) | 2018-12-06 |
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| US20130303436A1 (en) | 2013-11-14 |
| EP3287172A1 (en) | 2018-02-28 |
| JP2018021033A (ja) | 2018-02-08 |
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| EEER | Examination request |
Effective date: 20180411 |
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| FZDE | Discontinued |
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