CA2892104C - Treatment for pulmonary hypertension - Google Patents
Treatment for pulmonary hypertension Download PDFInfo
- Publication number
- CA2892104C CA2892104C CA2892104A CA2892104A CA2892104C CA 2892104 C CA2892104 C CA 2892104C CA 2892104 A CA2892104 A CA 2892104A CA 2892104 A CA2892104 A CA 2892104A CA 2892104 C CA2892104 C CA 2892104C
- Authority
- CA
- Canada
- Prior art keywords
- therapeutic agent
- pulmonary hypertension
- treprostinil
- oral
- inhaled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US28265910P | 2010-03-15 | 2010-03-15 | |
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| CA2791081A CA2791081C (en) | 2010-03-15 | 2011-03-14 | Treatment for pulmonary hypertension |
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| CA2791081A Division CA2791081C (en) | 2010-03-15 | 2011-03-14 | Treatment for pulmonary hypertension |
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| CA2892104A1 CA2892104A1 (en) | 2011-09-22 |
| CA2892104C true CA2892104C (en) | 2016-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2892104A Active CA2892104C (en) | 2010-03-15 | 2011-03-14 | Treatment for pulmonary hypertension |
| CA2791081A Active CA2791081C (en) | 2010-03-15 | 2011-03-14 | Treatment for pulmonary hypertension |
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| CA2791081A Active CA2791081C (en) | 2010-03-15 | 2011-03-14 | Treatment for pulmonary hypertension |
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| EP (2) | EP3108888B1 (enExample) |
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| CA (2) | CA2892104C (enExample) |
| ES (2) | ES2790859T3 (enExample) |
| WO (1) | WO2011115922A1 (enExample) |
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| CN103274926B (zh) | 2007-12-17 | 2016-08-10 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| KR20160132501A (ko) | 2010-03-15 | 2016-11-18 | 유나이티드 세러퓨틱스 코오포레이션 | 폐고혈압의 치료 |
| KR101868166B1 (ko) | 2010-06-03 | 2018-06-15 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 제조 |
| JP5580491B2 (ja) | 2011-03-02 | 2014-08-27 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル製造のための中間体の合成 |
| US9387214B2 (en) | 2012-01-13 | 2016-07-12 | United Therapeutics Corporation | Method of identifying therapies for pulmonary hypertension |
| CA3212313A1 (en) | 2013-03-14 | 2014-10-02 | United Therapeutics Corporation | Solid forms of treprostinil |
| CA2904598C (en) | 2013-03-15 | 2021-10-05 | United Therapeutics Corporation | Salts of treprostinil |
| CN105228451B (zh) | 2013-03-25 | 2018-03-30 | 联合治疗公司 | 制备具有硫醇连接子和聚乙二醇化形式的前列环素化合物的方法 |
| US20170049739A1 (en) | 2013-10-25 | 2017-02-23 | Insmed Incorporated | Prostacyclin compounds, compositions and methods of use thereof |
| WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| WO2015192030A1 (en) | 2014-06-13 | 2015-12-17 | United Therapeutics Corporation | Treprostinil formulations |
| ES2778274T3 (es) | 2014-10-20 | 2020-08-10 | United Therapeutics Corp | Síntesis de productos intermedios para producir derivados de prostaciclina |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
| RS62011B1 (sr) | 2016-07-15 | 2021-07-30 | Acceleron Pharma Inc | Kompozicije koje sadrže polipeptide actriia za upotrebu u lečenju plućne hipertenzije |
| CN110678174A (zh) | 2016-09-26 | 2020-01-10 | 联合治疗学有限公司 | 曲前列环素的前药 |
| CA3046025A1 (en) * | 2016-12-14 | 2018-06-21 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
| KR20190030805A (ko) * | 2017-09-14 | 2019-03-25 | 경상대학교산학협력단 | 폐고혈압 예방 또는 치료용 흡입제, 및 이의 투여방법 |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| CN112739679B (zh) | 2018-09-18 | 2024-03-12 | 伊莱利利公司 | 曲前列环素的特丁胺盐 |
| MX2021013329A (es) | 2019-04-29 | 2022-03-17 | Insmed Inc | Composiciones de polvo seco de los profarmacos de treprostinil y métodos de uso de las mismas. |
| US12064406B2 (en) * | 2019-05-14 | 2024-08-20 | Pharmosa Biopharm Inc. | Pharmaceutical composition of a weak acid drug and methods of administration |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| EP4135707A1 (en) | 2020-04-17 | 2023-02-22 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| CN116113415A (zh) | 2020-06-09 | 2023-05-12 | 联合治疗公司 | 曲前列尼尔的富马酰基二酮哌啶前药 |
| JP2023553989A (ja) | 2020-12-14 | 2023-12-26 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグで疾患を治療する方法 |
| KR20240012354A (ko) | 2021-03-03 | 2024-01-29 | 유나이티드 쎄러퓨틱스 코포레이션 | (e)-3,6-비스[4-(n-카보닐-2-프로페닐)아미도부틸]-2,5-디케토피페라진(fdkp)을 추가로 포함하는, 트레프로스티닐 및 이의 프로드러그의 건조 분말 조성물 |
| AU2023219692A1 (en) | 2022-02-08 | 2024-08-01 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| US20250288597A1 (en) | 2022-04-29 | 2025-09-18 | Zhaoke Pharmaceutical (Guangzhou) Co., Ltd | Treprostinil soft mist inhalant |
| CN121241041A (zh) | 2023-01-19 | 2025-12-30 | 联合治疗公司 | 曲前列尼尔类似物及相关制备和使用方法 |
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| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| GB8814438D0 (en) | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| GB9011588D0 (en) | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
| KR100638684B1 (ko) | 1997-11-14 | 2006-10-27 | 유나이티드 세러퓨틱스 코오포레이션 | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| US6803386B2 (en) | 2002-01-16 | 2004-10-12 | United Therapeutics Corporation | Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer |
| EP1628654B2 (en) | 2003-05-22 | 2019-12-04 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| ATE441418T1 (de) | 2003-12-16 | 2009-09-15 | United Therapeutics Corp | Verwendung von treprostinil zur verbesserung der nierenfunktion |
| ATE473736T1 (de) | 2003-12-16 | 2010-07-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von ischämischen läsionen |
| ATE462427T1 (de) | 2004-04-12 | 2010-04-15 | United Therapeutics Corp | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren |
| WO2007134292A2 (en) | 2006-05-15 | 2007-11-22 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| US20090036465A1 (en) | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| JP2010518122A (ja) * | 2007-02-09 | 2010-05-27 | ユナイテッド セラピューティクス コーポレーション | 間質性肺疾患および喘息のためのトレプロスチニル処置 |
| CN103181893A (zh) | 2007-09-07 | 2013-07-03 | 联合治疗公司 | 针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法 |
| KR20110010753A (ko) | 2008-05-08 | 2011-02-07 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 일수화물 |
| CN102164487A (zh) | 2008-09-25 | 2011-08-24 | 阿拉迪姆公司 | 曲前列素的深肺部递送 |
| WO2010129757A1 (en) | 2009-05-07 | 2010-11-11 | United Therapeutics Corporation | Solid formulations of prostacyclin analogs |
| KR20160132501A (ko) | 2010-03-15 | 2016-11-18 | 유나이티드 세러퓨틱스 코오포레이션 | 폐고혈압의 치료 |
| WO2012006273A1 (en) | 2010-07-09 | 2012-01-12 | United Therapeutics Corporation | Combination therapies with cox-2 inhibitors and treprostinil |
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- 2011-03-14 US US13/047,033 patent/US8609728B2/en active Active
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| KR20160132501A (ko) | 2016-11-18 |
| EP2547341A1 (en) | 2013-01-23 |
| CA2791081C (en) | 2015-08-25 |
| JP2015129129A (ja) | 2015-07-16 |
| US8609728B2 (en) | 2013-12-17 |
| US20130253049A1 (en) | 2013-09-26 |
| EP3108888A1 (en) | 2016-12-28 |
| JP2018135383A (ja) | 2018-08-30 |
| CN102883722B (zh) | 2014-11-05 |
| US20110224236A1 (en) | 2011-09-15 |
| CA2892104A1 (en) | 2011-09-22 |
| KR101508047B1 (ko) | 2015-04-06 |
| JP2013522303A (ja) | 2013-06-13 |
| JP2016153413A (ja) | 2016-08-25 |
| EP2547341B1 (en) | 2016-09-14 |
| US8969409B2 (en) | 2015-03-03 |
| EP3108888B1 (en) | 2020-02-12 |
| ES2790859T3 (es) | 2020-10-29 |
| WO2011115922A1 (en) | 2011-09-22 |
| JP5681276B2 (ja) | 2015-03-04 |
| KR20150027846A (ko) | 2015-03-12 |
| CA2791081A1 (en) | 2011-09-22 |
| ES2611187T3 (es) | 2017-05-05 |
| CN102883722A (zh) | 2013-01-16 |
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