CA2890642C - Method for the preparation of human albumin with reduced level of dissolved oxygen - Google Patents

Method for the preparation of human albumin with reduced level of dissolved oxygen Download PDF

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Publication number
CA2890642C
CA2890642C CA2890642A CA2890642A CA2890642C CA 2890642 C CA2890642 C CA 2890642C CA 2890642 A CA2890642 A CA 2890642A CA 2890642 A CA2890642 A CA 2890642A CA 2890642 C CA2890642 C CA 2890642C
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CA
Canada
Prior art keywords
albumin
solution
stage
dissolved oxygen
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2890642A
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English (en)
French (fr)
Other versions
CA2890642A1 (en
Inventor
Juan Ignacio Jorquera Nieto
Ana Maria Ortiz Fernandez
Montserrat Costa Rierola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grifols SA
Original Assignee
Grifols SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of CA2890642A1 publication Critical patent/CA2890642A1/en
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Publication of CA2890642C publication Critical patent/CA2890642C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2890642A 2014-05-29 2015-05-01 Method for the preparation of human albumin with reduced level of dissolved oxygen Active CA2890642C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201430824A ES2524516B1 (es) 2014-05-29 2014-05-29 Procedimiento de preparación de albúmina humana con nivel de oxígeno disuelto reducido
ES201430824 2014-05-29

Publications (2)

Publication Number Publication Date
CA2890642A1 CA2890642A1 (en) 2015-11-29
CA2890642C true CA2890642C (en) 2019-02-12

Family

ID=52003454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2890642A Active CA2890642C (en) 2014-05-29 2015-05-01 Method for the preparation of human albumin with reduced level of dissolved oxygen

Country Status (22)

Country Link
US (1) US10350274B2 (https=)
EP (1) EP2952203B9 (https=)
JP (3) JP2015224251A (https=)
KR (1) KR101960729B1 (https=)
CN (1) CN105315362B (https=)
AR (1) AR100618A1 (https=)
AU (1) AU2015202413B2 (https=)
BR (1) BR102015012091A8 (https=)
CA (1) CA2890642C (https=)
CL (1) CL2015001446A1 (https=)
ES (2) ES2524516B1 (https=)
HU (1) HUE031823T2 (https=)
IL (1) IL238898B (https=)
MX (1) MX362869B (https=)
MY (1) MY171771A (https=)
NZ (1) NZ708537A (https=)
PL (1) PL2952203T3 (https=)
PT (1) PT2952203T (https=)
RU (1) RU2657578C2 (https=)
SG (1) SG10201504137PA (https=)
TW (1) TWI607018B (https=)
ZA (1) ZA201503539B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2524516B1 (es) * 2014-05-29 2015-03-31 Grifols Worldwide Operations Limited Procedimiento de preparación de albúmina humana con nivel de oxígeno disuelto reducido
EP3995141B1 (en) 2016-04-28 2024-01-03 Alkahest, Inc. Plasma fractions as therapy for thymic cancer
LT3484502T (lt) 2016-08-18 2021-12-10 Alkahest, Inc. Kraujo plazmos frakcijos, kaip su senėjimu susijusio pažinimo sutrikimo gydymo priemonė
MX2019012795A (es) 2017-04-26 2020-02-13 Alkahest Inc Régimen de dosificación para el tratamiento de deterioros cognitivos y motores con plasma de sangre y productos de plasma de sangre.
SG11202100347QA (en) 2018-07-20 2021-02-25 Alkahest Inc Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
SG11202103696XA (en) 2018-10-26 2021-05-28 Alkahest Inc Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery
CN109627322A (zh) * 2019-01-07 2019-04-16 中国科学院过程工程研究所 一种从Cohn组分Ⅴ上清中分离纯化人血清白蛋白的方法
AU2020378245A1 (en) 2019-11-04 2022-04-07 Alkahest, Inc. Blood plasma fractions for use in muscle regeneration
CN114746100B (zh) 2019-11-20 2024-10-25 万能溶剂有限公司 用于肝再生的血浆级分
EP4689665A1 (en) 2023-03-29 2026-02-11 Grifols Worldwide Operations Limited Compositions and methods of preparation of blood plasma products with reduced levels of fceriss autoantibodies
CN118166053B (zh) * 2024-03-15 2025-02-07 通化安睿特生物制药股份有限公司 一种制备低o-糖基化水平的重组人白蛋白的方法
WO2025230830A1 (en) 2024-04-29 2025-11-06 Alkahest, Inc. Compositions of blood plasma fractions and their use in treatment of spinal muscular atrophy (sma)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same
SE9301581D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation
JPH07126182A (ja) * 1993-10-27 1995-05-16 Green Cross Corp:The 組換えヒト血清アルブミン製剤の滅菌方法
SE9402119D0 (sv) * 1994-06-16 1994-06-16 Pharmacia Ab Solution
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
JP4254117B2 (ja) * 2001-03-27 2009-04-15 ニプロ株式会社 アルブミン溶液収容プラスチック容器
DE60234142D1 (de) * 2001-03-27 2009-12-10 Nipro Corp Albuminlösung enthaltender Kunststoffbehälter
JP4225416B2 (ja) * 2001-06-29 2009-02-18 旭化成ファーマ株式会社 タンパク質製剤の安定性を改善する方法
US7252799B2 (en) * 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
ATE342904T1 (de) * 2003-08-28 2006-11-15 Nipro Corp Künstlicher sauerstoffträger und herstellungsverfahren dafür
HRP20120994T1 (hr) * 2006-02-07 2012-12-31 Shire Human Genetic Therapies, Inc. Stabilizirana smjesa glukocerebrozidaze
ES2294976B1 (es) * 2007-11-12 2008-12-16 Grifols, S.A. "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion".
JP5990880B2 (ja) * 2011-08-31 2016-09-14 東レ株式会社 有用タンパク質組成物およびその製造方法
CN102816230B (zh) * 2012-08-27 2014-02-12 同路生物制药股份有限公司 人血白蛋白的制备方法
ES2524516B1 (es) * 2014-05-29 2015-03-31 Grifols Worldwide Operations Limited Procedimiento de preparación de albúmina humana con nivel de oxígeno disuelto reducido

Also Published As

Publication number Publication date
MX2015006407A (es) 2015-11-30
US20150343025A1 (en) 2015-12-03
ES2524516B1 (es) 2015-03-31
US20170000855A9 (en) 2017-01-05
KR101960729B1 (ko) 2019-03-21
SG10201504137PA (en) 2015-12-30
CA2890642A1 (en) 2015-11-29
KR20160024348A (ko) 2016-03-04
US10350274B2 (en) 2019-07-16
ZA201503539B (en) 2017-01-25
TW201544510A (zh) 2015-12-01
JP2015224251A (ja) 2015-12-14
EP2952203B9 (en) 2018-03-14
ES2601137T3 (es) 2017-02-14
TWI607018B (zh) 2017-12-01
PT2952203T (pt) 2016-11-23
MX362869B (es) 2019-02-20
RU2015118453A (ru) 2016-12-10
IL238898B (en) 2018-01-31
PL2952203T3 (pl) 2017-02-28
JP2018115210A (ja) 2018-07-26
AR100618A1 (es) 2016-10-19
CN105315362A (zh) 2016-02-10
EP2952203B1 (en) 2016-10-26
EP2952203A1 (en) 2015-12-09
AU2015202413B2 (en) 2017-08-31
RU2657578C2 (ru) 2018-06-14
ES2524516A1 (es) 2014-12-09
CN105315362B (zh) 2019-10-25
AU2015202413A1 (en) 2015-12-17
BR102015012091A8 (pt) 2021-03-16
MY171771A (en) 2019-10-29
NZ708537A (en) 2017-06-30
JP2020111614A (ja) 2020-07-27
HUE031823T2 (en) 2017-08-28
CL2015001446A1 (es) 2016-05-13
BR102015012091A2 (pt) 2016-01-05

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