CA2885619C - Topical ketoprofen composition - Google Patents

Topical ketoprofen composition Download PDF

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Publication number
CA2885619C
CA2885619C CA2885619A CA2885619A CA2885619C CA 2885619 C CA2885619 C CA 2885619C CA 2885619 A CA2885619 A CA 2885619A CA 2885619 A CA2885619 A CA 2885619A CA 2885619 C CA2885619 C CA 2885619C
Authority
CA
Canada
Prior art keywords
percent
ketoprofen
composition
carbopol
oxybenzone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2885619A
Other languages
English (en)
French (fr)
Other versions
CA2885619A1 (en
Inventor
Servet Buyuktimkin
Nadir Buyuktimkin
James L. Yeager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achelios Therapeutics Inc
Original Assignee
Achelios Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achelios Therapeutics Inc filed Critical Achelios Therapeutics Inc
Publication of CA2885619A1 publication Critical patent/CA2885619A1/en
Application granted granted Critical
Publication of CA2885619C publication Critical patent/CA2885619C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA2885619A 2012-09-27 2013-09-24 Topical ketoprofen composition Active CA2885619C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261706163P 2012-09-27 2012-09-27
US61/706,163 2012-09-27
US13/826,706 US8822537B2 (en) 2012-09-27 2013-03-14 Topical ketoprofen composition
US13/826,706 2013-03-14
PCT/US2013/061403 WO2014052313A1 (en) 2012-09-27 2013-09-24 Topical ketoprofen composition

Publications (2)

Publication Number Publication Date
CA2885619A1 CA2885619A1 (en) 2014-04-03
CA2885619C true CA2885619C (en) 2020-09-08

Family

ID=50339476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2885619A Active CA2885619C (en) 2012-09-27 2013-09-24 Topical ketoprofen composition

Country Status (13)

Country Link
US (1) US8822537B2 (https=)
EP (1) EP2900231B1 (https=)
JP (1) JP6238991B2 (https=)
KR (1) KR102184245B1 (https=)
AU (1) AU2013323766B2 (https=)
BR (1) BR112015006790B1 (https=)
CA (1) CA2885619C (https=)
ES (1) ES2902850T3 (https=)
IL (1) IL237810B (https=)
MX (1) MX373916B (https=)
NZ (1) NZ706108A (https=)
RU (1) RU2652345C2 (https=)
WO (1) WO2014052313A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6205133B2 (ja) 2009-07-10 2017-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
WO2016089893A1 (en) * 2014-12-01 2016-06-09 Achelios Therapeutics Inc. Methods and compositions for treating migraine and conditions associated with pain
KR20180069782A (ko) 2015-08-03 2018-06-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 하전 이온 채널 블록커 및 이용 방법
CA3045004A1 (en) * 2015-12-16 2017-06-22 Achelios Therapeutics, Inc. Methods and compositions for treating peripheral neuropathy
CA3019582A1 (en) * 2016-03-31 2017-10-05 Smartech Topical, Inc. Delivery system
AU2018376176A1 (en) * 2017-11-30 2020-07-02 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Stable liquid composition of ketoprofen, salts and enantiomers thereof
MX2021010869A (es) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueadores de canales iónicos sustituidos por éster y métodos para su uso.
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2020235888A1 (en) 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ION channel blockers and methods for use
US10934263B2 (en) 2019-03-11 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3139559A1 (en) 2019-05-09 2020-11-12 Apkarian Technologies Llc Methods and compositions for treating pain
JP7515582B2 (ja) * 2019-11-06 2024-07-12 スマーテック トピカル，インコーポレイテッド シクロオキシゲナーゼ阻害剤の局所配合剤およびその使用
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN119118953A (zh) 2020-03-11 2024-12-13 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60155111A (ja) * 1983-10-20 1985-08-15 Hisamitsu Pharmaceut Co Inc 安定なケトプロフェン含有外用経皮製剤
US5863527A (en) * 1996-09-04 1999-01-26 The Proctor & Gamble Company Personal care compositions
US6423697B1 (en) * 1999-01-14 2002-07-23 Mark Friedman Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache, facial pain, and cervical-muscle spasm
FR2804024B1 (fr) 2000-01-21 2002-09-13 Menarini France Nouvelles compositions pharmaceutiques a action anti- inflammatoire et leur procede de preparation
CN1536983A (zh) * 2001-05-30 2004-10-13 宝洁公司 包括取代的化妆品键合剂的局部组合物
DE10141258B4 (de) * 2001-08-23 2004-09-23 Beiersdorf Ag Kosmetische und dermatologische Zubereitung und ihre Verwendung
US7235230B2 (en) * 2001-10-24 2007-06-26 Clariant Finance (Bvi) Limited Leave-on compositions for personal care
ITFI20030070A1 (it) * 2003-03-18 2004-09-19 Berlin Chemie Ag Formulazioni topiche stabilizzate contenenti ketoprofene
EP1488787A1 (en) 2003-06-20 2004-12-22 Berlin-Chemie Ag Topical stabilized formulations containing ketoprofen
ATE534373T1 (de) * 2003-10-10 2011-12-15 Antares Pharma Ipl Ag Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut
US7928144B2 (en) * 2004-06-15 2011-04-19 Hisamitsu Pharmaceutical Co., Inc. Antiinflammatory and analgesic preparation for external use
EP1872796B1 (en) * 2005-02-25 2011-09-21 Hisamitsu Pharmaceutical Co., Inc. Transdermal preparation for external use containing nonsteroidal antiinflammatory/analgesic agent
AU2006290297A1 (en) * 2005-09-15 2007-03-22 Biomas Ltd. Use of tellurium compounds for protection from ultra-violet radiation
EP2010132A1 (en) * 2006-04-18 2009-01-07 DSMIP Assets B.V. Cosmetic compositions comprising salicylic acid and ascorbic acid
WO2009139817A2 (en) * 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US8409600B2 (en) * 2009-01-23 2013-04-02 J&E Solutions, Llc Methods for prevention and/or treatment of capsular contracture
US20130109674A1 (en) * 2009-12-18 2013-05-02 Achelios Therapeutics Llc Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions

Also Published As

Publication number Publication date
BR112015006790B1 (pt) 2022-05-31
MX2015004006A (es) 2015-10-29
KR102184245B1 (ko) 2020-11-30
JP2015531374A (ja) 2015-11-02
BR112015006790A2 (pt) 2017-07-04
US8822537B2 (en) 2014-09-02
CA2885619A1 (en) 2014-04-03
RU2652345C2 (ru) 2018-04-25
HK1212898A1 (en) 2016-06-24
JP6238991B2 (ja) 2017-11-29
KR20150074009A (ko) 2015-07-01
US20140088195A1 (en) 2014-03-27
NZ706108A (en) 2018-03-23
EP2900231A1 (en) 2015-08-05
MX373916B (es) 2020-07-10
RU2015115723A (ru) 2016-11-20
IL237810B (en) 2018-06-28
EP2900231A4 (en) 2016-03-02
WO2014052313A1 (en) 2014-04-03
EP2900231B1 (en) 2021-11-03
ES2902850T3 (es) 2022-03-30
AU2013323766B2 (en) 2017-08-17
AU2013323766A1 (en) 2015-04-09

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Effective date: 20180921

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Effective date: 20250325