CA2882977C - Transgenic microalgae and use thereof for oral delivery of proteins - Google Patents
Transgenic microalgae and use thereof for oral delivery of proteins Download PDFInfo
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- CA2882977C CA2882977C CA2882977A CA2882977A CA2882977C CA 2882977 C CA2882977 C CA 2882977C CA 2882977 A CA2882977 A CA 2882977A CA 2882977 A CA2882977 A CA 2882977A CA 2882977 C CA2882977 C CA 2882977C
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/575—Hormones
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
Landscapes
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| PCT/IL2013/050712 WO2014030165A1 (en) | 2012-08-23 | 2013-08-21 | Transgenic microalgae and use thereof for oral delivery of proteins |
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| US10480002B2 (en) | 2014-02-12 | 2019-11-19 | Transalgae Israel Ltd. | Algal based edible vaccines |
| US20190373915A1 (en) * | 2014-10-24 | 2019-12-12 | Trustees Of Dartmouth College | Aquaculture Feed Formulation and Aquaculture Product Produced with the Same |
| CL2014003348A1 (es) * | 2014-12-09 | 2016-09-02 | Oceaneos Environmental Solutions Inc | Isotopos de hierro no radiactivos y método de uso para rastrear especies marinas |
| JP2017012135A (ja) * | 2015-07-06 | 2017-01-19 | 国立大学法人高知大学 | ベクター、遺伝子組み換え海産珪藻及びフコキサンチンの生成方法 |
| CN107849515A (zh) * | 2015-07-14 | 2018-03-27 | 特郎萨格以色列有限公司 | 转基因微藻及其作为用于递送干扰rna分子的饲料的用途 |
| GB201616087D0 (en) * | 2016-09-21 | 2016-11-02 | Tomalgae Cvba | Algae comprising therapeutic and/or nutritional agents |
| KR102013788B1 (ko) * | 2016-11-04 | 2019-08-23 | 한국과학기술연구원 | 인간상피세포 성장인자 또는 피부침투성 인간상피세포 성장인자 발현용 벡터 및 상기 벡터로 형질전환된 미세조류 |
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| KR102080864B1 (ko) * | 2017-10-24 | 2020-02-24 | 주식회사 비엠바이오 | 항비만, 항당뇨 기능성을 갖는 미세조류를 이용한 기능성 애완동물 사료 조성물 |
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| US20080107652A1 (en) | 2006-08-25 | 2008-05-08 | Science & Technology Corporation @ University Of New Mexico Stc.Unm | Methods and compositions for control of disease in aquaculture |
| US20090205075A1 (en) * | 2008-01-30 | 2009-08-13 | Stacy Miles | Use of plastid transit peptides derived from glaucocystophytes |
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| US20110081706A1 (en) | 2009-10-02 | 2011-04-07 | TransAlgae Ltd | Method and system for efficient harvesting of microalgae and cyanobacteria |
| US20120309939A1 (en) | 2009-11-19 | 2012-12-06 | The Scripps Research Institute | Production of Therapeutic Proteins in Photosynthetic Organisms |
| US20130065314A1 (en) * | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
| WO2013052755A1 (en) * | 2011-10-06 | 2013-04-11 | University Of Wyoming | Method for harvesting photosynthetic unicells using genetically induced flotation |
| CN102559735A (zh) * | 2011-12-28 | 2012-07-11 | 广东海洋大学 | 一种通过转基因微藻生产神经酸的方法 |
| CA2882977C (en) | 2012-08-23 | 2019-05-21 | Transalgae Israel Ltd. | Transgenic microalgae and use thereof for oral delivery of proteins |
| US8883993B2 (en) * | 2012-12-04 | 2014-11-11 | Exxonmobil Research And Engineering Company | Tetraselmis promoters and terminators for use in eukaryotic cells |
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| WO2014030165A1 (en) | 2014-02-27 |
| US20180036357A1 (en) | 2018-02-08 |
| IL237359A0 (en) | 2015-04-30 |
| EP2887819A1 (en) | 2015-07-01 |
| EP2887819A4 (en) | 2016-04-06 |
| CN108929855A (zh) | 2018-12-04 |
| CN104754954A (zh) | 2015-07-01 |
| IN2015MN00403A (cg-RX-API-DMAC7.html) | 2015-09-04 |
| CN104754954B (zh) | 2018-08-28 |
| JP6275143B2 (ja) | 2018-02-07 |
| CA2882977A1 (en) | 2014-02-27 |
| US11344590B2 (en) | 2022-05-31 |
| IL237359B (en) | 2019-01-31 |
| JP2015531596A (ja) | 2015-11-05 |
| US20150164965A1 (en) | 2015-06-18 |
| EP2887819B1 (en) | 2018-07-25 |
| US9827280B2 (en) | 2017-11-28 |
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