IN2015MN00403A - - Google Patents

Info

Publication number
IN2015MN00403A
IN2015MN00403A IN403MUN2015A IN2015MN00403A IN 2015MN00403 A IN2015MN00403 A IN 2015MN00403A IN 403MUN2015 A IN403MUN2015 A IN 403MUN2015A IN 2015MN00403 A IN2015MN00403 A IN 2015MN00403A
Authority
IN
India
Prior art keywords
biologically active
protein
microalgae
algae
expressing
Prior art date
Application number
Inventor
Shiri Moshitzky
Doron Eisenstadt
Guy Levi
Ofra Chen
Original Assignee
Transalgae Israel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transalgae Israel Ltd filed Critical Transalgae Israel Ltd
Publication of IN2015MN00403A publication Critical patent/IN2015MN00403A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Wood Science & Technology (AREA)
  • Botany (AREA)
  • Insects & Arthropods (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)

Abstract

The present invention provides transgenic microalgae expressing at least one exogenous biologically active protein. The protein expressing microalgae are used for the oral delivery of the biologically active protein to the target organism in its intact and functional form. The exogenous protein expressed in algae is characterized by being biologically active exerting at least one specific activity having a beneficial effect on the subject consuming the algae. Particularly the transgenic microalgae are used as animal food for aquatic or land animals welfare or as food supplement for human healthcare.
IN403MUN2015 2012-08-23 2013-08-21 IN2015MN00403A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261692240P 2012-08-23 2012-08-23
US201361781103P 2013-03-14 2013-03-14
PCT/IL2013/050712 WO2014030165A1 (en) 2012-08-23 2013-08-21 Transgenic microalgae and use thereof for oral delivery of proteins

Publications (1)

Publication Number Publication Date
IN2015MN00403A true IN2015MN00403A (en) 2015-09-04

Family

ID=50149519

Family Applications (1)

Application Number Title Priority Date Filing Date
IN403MUN2015 IN2015MN00403A (en) 2012-08-23 2013-08-21

Country Status (9)

Country Link
US (2) US9827280B2 (en)
EP (1) EP2887819B1 (en)
JP (1) JP6275143B2 (en)
CN (2) CN108929855A (en)
CA (1) CA2882977C (en)
IL (1) IL237359B (en)
IN (1) IN2015MN00403A (en)
TR (1) TR201814868T4 (en)
WO (1) WO2014030165A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2015MN00403A (en) 2012-08-23 2015-09-04 Transalgae Israel Ltd
CN106029091B (en) * 2014-02-12 2020-02-11 特郎萨格以色列有限公司 Algal-based edible vaccines
US20190373915A1 (en) * 2014-10-24 2019-12-12 Trustees Of Dartmouth College Aquaculture Feed Formulation and Aquaculture Product Produced with the Same
CL2014003348A1 (en) * 2014-12-09 2016-09-02 Oceaneos Environmental Solutions Inc Non-radioactive iron isotopes and method of use to track marine species
JP2017012135A (en) * 2015-07-06 2017-01-19 国立大学法人高知大学 Vector, genetically engineered marine diatom, and method for producing fucoxanthin
WO2017009838A1 (en) 2015-07-14 2017-01-19 Transalgae Israel Ltd. Transgenic microalgae and use thereof as a feed for delivery of interfering rna molecules
GB201616087D0 (en) * 2016-09-21 2016-11-02 Tomalgae Cvba Algae comprising therapeutic and/or nutritional agents
KR102013788B1 (en) * 2016-11-04 2019-08-23 한국과학기술연구원 A vector for expressing hEGF or PTD-hEGF and microalgae transformed with the same
CA3027654C (en) * 2017-01-20 2021-02-16 Sanriku Fish Meal Co., Ltd. Method for manufacturing feed containing salmon growth hormone, feed containing salmon growth hormone, and liquid containing salmon growth hormone
KR102080864B1 (en) * 2017-10-24 2020-02-24 주식회사 비엠바이오 Functional feed composition for pet using microalgae having antiobecity and antidiabetes
JP2020202786A (en) * 2019-06-17 2020-12-24 国立研究開発法人国際農林水産業研究センター Microalgae culture method
CN111394381A (en) * 2020-03-26 2020-07-10 上海海洋大学 method for enriching artemia nauplii with mOrange and vp28 shuttle vector
WO2023245240A1 (en) * 2022-06-22 2023-12-28 Provectus Algae Pty Ltd Promotion of synchronous sexual maturation and spawning in aquatic animals

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US5643877A (en) * 1994-12-05 1997-07-01 University Of Maryland Biotechnology Institute Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish
US6027900A (en) 1996-04-12 2000-02-22 Carnegie Institution Of Washington Methods and tools for transformation of eukaryotic algae
US6720014B1 (en) * 1997-08-13 2004-04-13 Diversa Corporation Phytase-containing foodstuffs and methods of making and using them
CN1330718A (en) * 1998-10-07 2002-01-09 辛根塔参与股份公司 Therapeutically active proteins in plants
US20030022359A1 (en) 2000-06-20 2003-01-30 Sayre Richard T. Transgenic algae for delivering antigens to an animal
US7081567B2 (en) * 2000-12-03 2006-07-25 Lexun Xue Transgenic dunaliella salina as a bioreactor
AU2002255851B2 (en) 2001-03-23 2008-03-06 Advanced Bionutrition Microbial feeds for aquaculture and agriculture
US20070148166A1 (en) * 2002-05-13 2007-06-28 Wu Madeline C S Scfvs in photosynthetic microbes
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CN1325652C (en) * 2005-10-13 2007-07-11 上海交通大学 Improvement for exogenous protein accumulation in transgene plant
US20080107652A1 (en) 2006-08-25 2008-05-08 Science & Technology Corporation @ University Of New Mexico Stc.Unm Methods and compositions for control of disease in aquaculture
US20090205075A1 (en) * 2008-01-30 2009-08-13 Stacy Miles Use of plastid transit peptides derived from glaucocystophytes
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Also Published As

Publication number Publication date
CN108929855A (en) 2018-12-04
EP2887819B1 (en) 2018-07-25
US20150164965A1 (en) 2015-06-18
CA2882977A1 (en) 2014-02-27
EP2887819A1 (en) 2015-07-01
IL237359A0 (en) 2015-04-30
EP2887819A4 (en) 2016-04-06
US11344590B2 (en) 2022-05-31
CN104754954B (en) 2018-08-28
US9827280B2 (en) 2017-11-28
CN104754954A (en) 2015-07-01
JP6275143B2 (en) 2018-02-07
JP2015531596A (en) 2015-11-05
TR201814868T4 (en) 2018-10-22
IL237359B (en) 2019-01-31
US20180036357A1 (en) 2018-02-08
WO2014030165A1 (en) 2014-02-27
CA2882977C (en) 2019-05-21

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