CA2880422C - Derivatives of 5-aminolevulinic acid - Google Patents
Derivatives of 5-aminolevulinic acid Download PDFInfo
- Publication number
- CA2880422C CA2880422C CA2880422A CA2880422A CA2880422C CA 2880422 C CA2880422 C CA 2880422C CA 2880422 A CA2880422 A CA 2880422A CA 2880422 A CA2880422 A CA 2880422A CA 2880422 C CA2880422 C CA 2880422C
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- CA
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- Prior art keywords
- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179277 | 2012-08-03 | ||
| EP12179277.4 | 2012-08-03 | ||
| EP12197305.1 | 2012-12-14 | ||
| EP12197305 | 2012-12-14 | ||
| PCT/EP2013/066317 WO2014020164A1 (en) | 2012-08-03 | 2013-08-02 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2880422A1 CA2880422A1 (en) | 2014-02-06 |
| CA2880422C true CA2880422C (en) | 2021-02-09 |
Family
ID=48948407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2880422A Active CA2880422C (en) | 2012-08-03 | 2013-08-02 | Derivatives of 5-aminolevulinic acid |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9249086B2 (https=) |
| EP (1) | EP2880012B1 (https=) |
| JP (1) | JP6280117B2 (https=) |
| KR (1) | KR102180174B1 (https=) |
| CN (1) | CN104661994B (https=) |
| AU (1) | AU2013298525B2 (https=) |
| BR (1) | BR112015002390B1 (https=) |
| CA (1) | CA2880422C (https=) |
| CL (1) | CL2015000233A1 (https=) |
| ES (1) | ES2908080T3 (https=) |
| IL (1) | IL236965B (https=) |
| IN (1) | IN2015DN00837A (https=) |
| MX (1) | MX364940B (https=) |
| NZ (1) | NZ629914A (https=) |
| RU (1) | RU2635563C2 (https=) |
| SG (1) | SG11201500805VA (https=) |
| WO (1) | WO2014020164A1 (https=) |
| ZA (1) | ZA201500778B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6595484B2 (ja) | 2013-12-20 | 2019-10-23 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 光損傷皮膚のパルス光力学的処置 |
| CN113061089A (zh) * | 2015-09-23 | 2021-07-02 | 凯瑞康宁生物工程（武汉）有限公司 | γ-羟基丁酸的前药及其组合物和用途 |
| BR112018011965A2 (pt) * | 2015-12-17 | 2018-12-04 | Photocure Asa | método de terapia fotodinâmica (pdt) para câncer de bexiga |
| GB201522309D0 (en) * | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| CN106187793A (zh) * | 2016-01-26 | 2016-12-07 | 赵鸣 | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 |
| DK3641882T3 (da) * | 2017-06-21 | 2023-12-18 | Photocure Asa | Fremgangsmåde til fremstilling af en flydende farmaceutisk sammensætning og indretning til anvendelse i en sådan fremgangsmåde |
| IL285384B2 (en) | 2019-02-13 | 2024-11-01 | Alpheus Medical Inc | Non-invasive sonodynamic therapy |
| MX2021014512A (es) | 2019-05-29 | 2022-02-11 | Sonalasense Inc | Sonosensibilizacion. |
| WO2022032283A2 (en) | 2020-08-07 | 2022-02-10 | Alpheus Medical, Inc. | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| CN120957714A (zh) | 2023-03-07 | 2025-11-14 | 光治疗Asa公司 | 膀胱癌疗法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07188133A (ja) | 1993-12-27 | 1995-07-25 | Asahi Chem Ind Co Ltd | δ−アミノレブリン酸またはその同族体の製造法 |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| ATE202076T1 (de) | 1995-03-10 | 2001-06-15 | Photocure Asa | Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie |
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| JPH1112197A (ja) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | 悪性腫瘍診断剤及び治療剤 |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| DE10202487A1 (de) | 2002-01-23 | 2003-07-31 | Photonamic Gmbh & Co Kg | Dermales Applikationssystem für Aminolävulinsäure-Derivate |
| DE10312659A1 (de) | 2003-03-21 | 2004-10-07 | Universität Regensburg | 5-Aminolävulinsäurederivate und ihre Verwendung |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| JP4417865B2 (ja) | 2004-03-30 | 2010-02-17 | コスモ石油株式会社 | ５−アミノレブリン酸リン酸塩、その製造方法及びその用途 |
| ES2355978T3 (es) * | 2004-03-30 | 2011-04-01 | Cosmo Oil Co., Ltd. | Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma. |
| JP4719483B2 (ja) | 2004-03-30 | 2011-07-06 | コスモ石油株式会社 | ５−アミノレブリン酸スルホン酸塩の製造方法 |
| GB0424833D0 (en) * | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| JP5404995B2 (ja) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | 植物のポリフェノール増量剤 |
| JP5039389B2 (ja) | 2007-02-02 | 2012-10-03 | コスモ石油株式会社 | ホップのアルファ酸又はホップオイル含量向上剤 |
| AU2008238787B2 (en) | 2007-03-30 | 2013-05-02 | Cosmo Trade & Service Co., Ltd. | Agent for improving alkali resistance of plant and method for improving alkali resistance of plant |
| JP4705616B2 (ja) | 2007-07-20 | 2011-06-22 | コスモ石油株式会社 | 植物における金属成分の吸収向上剤 |
| GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| AU2008337067A1 (en) * | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
| WO2009130893A1 (ja) | 2008-04-22 | 2009-10-29 | Ｓｂｉアラプロモ株式会社 | 膀胱がん検出方法 |
| AU2009247547B2 (en) | 2008-05-13 | 2013-10-10 | Cosmo Trade & Service Co., Ltd. | Agent for improving lawn grass qualities |
| JP5276894B2 (ja) | 2008-05-13 | 2013-08-28 | コスモ石油株式会社 | イネの健苗育成向上剤 |
| JP5323539B2 (ja) | 2009-03-11 | 2013-10-23 | コスモ石油株式会社 | 農作物の収穫部位の収量向上剤 |
-
2013
- 2013-08-02 CA CA2880422A patent/CA2880422C/en active Active
- 2013-08-02 AU AU2013298525A patent/AU2013298525B2/en active Active
- 2013-08-02 MX MX2015001374A patent/MX364940B/es active IP Right Grant
- 2013-08-02 BR BR112015002390-8A patent/BR112015002390B1/pt active IP Right Grant
- 2013-08-02 JP JP2015524805A patent/JP6280117B2/ja active Active
- 2013-08-02 US US14/419,125 patent/US9249086B2/en active Active
- 2013-08-02 EP EP13745829.5A patent/EP2880012B1/en active Active
- 2013-08-02 NZ NZ629914A patent/NZ629914A/en unknown
- 2013-08-02 IN IN837DEN2015 patent/IN2015DN00837A/en unknown
- 2013-08-02 WO PCT/EP2013/066317 patent/WO2014020164A1/en not_active Ceased
- 2013-08-02 RU RU2015104830A patent/RU2635563C2/ru active
- 2013-08-02 KR KR1020157003692A patent/KR102180174B1/ko active Active
- 2013-08-02 ES ES13745829T patent/ES2908080T3/es active Active
- 2013-08-02 CN CN201380048873.3A patent/CN104661994B/zh active Active
- 2013-08-02 SG SG11201500805VA patent/SG11201500805VA/en unknown
-
2015
- 2015-01-28 IL IL236965A patent/IL236965B/en active IP Right Grant
- 2015-01-30 CL CL2015000233A patent/CL2015000233A1/es unknown
- 2015-02-03 ZA ZA2015/00778A patent/ZA201500778B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ629914A (en) | 2017-02-24 |
| US9249086B2 (en) | 2016-02-02 |
| KR20150039208A (ko) | 2015-04-09 |
| US20150191419A1 (en) | 2015-07-09 |
| AU2013298525B2 (en) | 2017-12-14 |
| CN104661994B (zh) | 2017-08-08 |
| CL2015000233A1 (es) | 2015-04-24 |
| ES2908080T3 (es) | 2022-04-27 |
| MX2015001374A (es) | 2015-09-07 |
| EP2880012A1 (en) | 2015-06-10 |
| MX364940B (es) | 2019-05-15 |
| EP2880012B1 (en) | 2021-12-15 |
| RU2635563C2 (ru) | 2017-11-14 |
| KR102180174B1 (ko) | 2020-11-19 |
| BR112015002390A2 (pt) | 2017-07-04 |
| WO2014020164A1 (en) | 2014-02-06 |
| AU2013298525A1 (en) | 2015-03-05 |
| JP6280117B2 (ja) | 2018-02-14 |
| ZA201500778B (en) | 2016-04-28 |
| CA2880422A1 (en) | 2014-02-06 |
| BR112015002390B1 (pt) | 2020-03-24 |
| SG11201500805VA (en) | 2015-02-27 |
| JP2015528814A (ja) | 2015-10-01 |
| IL236965B (en) | 2019-03-31 |
| CN104661994A (zh) | 2015-05-27 |
| RU2015104830A (ru) | 2016-09-27 |
| HK1211283A1 (en) | 2016-05-20 |
| BR112015002390A8 (pt) | 2019-07-30 |
| IN2015DN00837A (https=) | 2015-06-12 |
Similar Documents
| Publication | Publication Date | Title |
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| CA2880422C (en) | Derivatives of 5-aminolevulinic acid | |
| US8410172B2 (en) | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | |
| JP3955093B2 (ja) | 光化学治療における光増感剤としての５−アミノレブリン酸のエステル | |
| US7217736B2 (en) | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | |
| US7247655B2 (en) | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy | |
| US7287646B2 (en) | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy | |
| CN112010772A (zh) | 5-氨基酮戊酸及其衍生物的盐化合物和应用 | |
| HK1211283B (en) | Compounds | |
| Romiszewska et al. | The use of 5-aminolevulinic acid and its derivatives in photodynamic therapy and diagnosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180730 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD Year of fee payment: 11 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240726 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240726 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD Year of fee payment: 12 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250725 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250725 |