CA2878082A1 - Smoothened modulators and methods of use thereof - Google Patents

Smoothened modulators and methods of use thereof Download PDF

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Publication number
CA2878082A1
CA2878082A1 CA2878082A CA2878082A CA2878082A1 CA 2878082 A1 CA2878082 A1 CA 2878082A1 CA 2878082 A CA2878082 A CA 2878082A CA 2878082 A CA2878082 A CA 2878082A CA 2878082 A1 CA2878082 A1 CA 2878082A1
Authority
CA
Canada
Prior art keywords
compound
amino
group
alkyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878082A
Other languages
English (en)
French (fr)
Inventor
Wei Chen
Jiangbo Wang
Robert A. Mook, Jr.
Lawrence S. Barak
H. Kim Lyerly
Anthony Angelo RIBEIRO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of CA2878082A1 publication Critical patent/CA2878082A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
CA2878082A 2012-09-17 2013-09-16 Smoothened modulators and methods of use thereof Abandoned CA2878082A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261701960P 2012-09-17 2012-09-17
US61/701,960 2012-09-17
PCT/US2013/059905 WO2014043608A2 (en) 2012-09-17 2013-09-16 Smoothened modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2878082A1 true CA2878082A1 (en) 2014-03-20

Family

ID=50278865

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878082A Abandoned CA2878082A1 (en) 2012-09-17 2013-09-16 Smoothened modulators and methods of use thereof

Country Status (4)

Country Link
US (1) US9512106B2 (en_2)
EP (1) EP2895474B1 (en_2)
CA (1) CA2878082A1 (en_2)
WO (1) WO2014043608A2 (en_2)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104926801B (zh) * 2014-03-22 2019-06-04 浙江大学 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用
CN108341801B (zh) 2017-01-24 2020-05-12 浙江大学 多氟取代芳联杂环类衍生物、含其的药物组合物及其应用
WO2020194141A1 (en) * 2019-03-26 2020-10-01 Università Degli Studi Di Roma "La Sapienza" Stable system for the in vitro culture of cerebellar granule cell precursors (gcp), stable method for the in vitro culture of said cells and use of said system or method for in vitro culture
WO2022046999A1 (en) * 2020-08-26 2022-03-03 Massachusetts Institute Of Technology Modulators of myb-mediated transcription and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6680299B2 (en) 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
MY134200A (en) 2002-04-12 2007-11-30 Kowa Co Method for treating cancer
PL1789390T3 (pl) 2004-09-02 2012-04-30 Genentech Inc Pirydylowe inhibitory szlaku sygnałowego hedgehog
JP5225857B2 (ja) 2005-11-14 2013-07-03 ジェネンテック，インコーポレイティド ヘッジホッグシグナル伝達のビスアミド阻害剤
UA93548C2 (uk) 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
AU2009241561B2 (en) 2008-04-29 2013-05-16 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
WO2009154739A2 (en) 2008-06-17 2009-12-23 Duke University Smoothened receptor modulators

Also Published As

Publication number Publication date
WO2014043608A2 (en) 2014-03-20
US20150166509A1 (en) 2015-06-18
EP2895474B1 (en) 2019-12-11
WO2014043608A3 (en) 2015-07-16
EP2895474A4 (en) 2016-08-24
EP2895474A2 (en) 2015-07-22
US9512106B2 (en) 2016-12-06

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180822

FZDE Discontinued

Effective date: 20210831

FZDE Discontinued

Effective date: 20210831