CA2876950C - Preparation of composition comprising gas microbubbles - Google Patents

Preparation of composition comprising gas microbubbles Download PDF

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Publication number
CA2876950C
CA2876950C CA2876950A CA2876950A CA2876950C CA 2876950 C CA2876950 C CA 2876950C CA 2876950 A CA2876950 A CA 2876950A CA 2876950 A CA2876950 A CA 2876950A CA 2876950 C CA2876950 C CA 2876950C
Authority
CA
Canada
Prior art keywords
gas
inlet
pipe
protein solution
microbubbles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2876950A
Other languages
English (en)
French (fr)
Other versions
CA2876950A1 (en
Inventor
Svein Kvaale
Ole Johannes Tokerud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CA2876950A1 publication Critical patent/CA2876950A1/en
Application granted granted Critical
Publication of CA2876950C publication Critical patent/CA2876950C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Accessories For Mixers (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
CA2876950A 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles Active CA2876950C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
EP12173606.0 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
CA2876950A1 CA2876950A1 (en) 2014-01-03
CA2876950C true CA2876950C (en) 2020-09-22

Family

ID=48699026

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2876950A Active CA2876950C (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Country Status (14)

Country Link
US (1) US10350314B2 (2)
EP (1) EP2864033B1 (2)
JP (1) JP6420761B2 (2)
KR (1) KR102139393B1 (2)
CN (1) CN104519989B (2)
AU (2) AU2013283409B2 (2)
BR (1) BR112014032254B1 (2)
CA (1) CA2876950C (2)
DK (1) DK2864033T3 (2)
ES (1) ES2571481T3 (2)
IN (1) IN2014DN10714A (2)
MX (1) MX354719B (2)
RU (1) RU2640078C2 (2)
WO (1) WO2014001297A2 (2)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10714A (2) 2012-06-26 2015-09-04 Ge Healthcare As
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
US11317888B2 (en) 2016-10-11 2022-05-03 Thomas Jefferson University Non-invasive method for pressure measurement
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法
US12345068B2 (en) 2021-11-19 2025-07-01 Sundance Spas, Inc. Self-maintaining hot tub or spa

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
HU218018B (hu) 1991-09-17 2000-05-28 Sonus Pharmaceuticals Inc. Gázos ultrahang-kontrasztanyag és eljárás ultrahang kontrasztanyaghoz megfelelő gázok kiválasztására
AU722742B2 (en) * 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
WO1995001187A1 (en) 1993-07-02 1995-01-12 Molecular Biosystems, Inc. Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
PL319600A1 (en) 1994-09-29 1997-08-18 Andaris Ltd Spray-dried microparticles as therapeutic carriers
ATE238072T1 (de) 1996-02-19 2003-05-15 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
TR199901544T2 (xx) * 1996-10-21 1999-09-21 Nycomed Imaging As Kontrast ajanlar�ndaki veya kontrast ajanlar�yla ilgili geli�meler.
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
JP4350058B2 (ja) * 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005052973B4 (de) * 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
DE102005020727A1 (de) 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
CN101507908B (zh) 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
IN2014DN10714A (2) 2012-06-26 2015-09-04 Ge Healthcare As

Also Published As

Publication number Publication date
DK2864033T3 (en) 2016-05-17
KR102139393B1 (ko) 2020-07-29
US10350314B2 (en) 2019-07-16
AU2013283409B2 (en) 2017-06-08
BR112014032254A2 (pt) 2017-06-27
CA2876950A1 (en) 2014-01-03
BR112014032254B1 (pt) 2022-11-01
RU2014150473A (ru) 2016-08-20
JP6420761B2 (ja) 2018-11-07
WO2014001297A2 (en) 2014-01-03
EP2864033B1 (en) 2016-04-06
JP2015524792A (ja) 2015-08-27
US20150250904A1 (en) 2015-09-10
EP2864033A2 (en) 2015-04-29
CN104519989B (zh) 2016-10-26
WO2014001297A3 (en) 2014-10-02
RU2640078C2 (ru) 2017-12-26
ES2571481T3 (es) 2016-05-25
KR20150024420A (ko) 2015-03-06
AU2017216553A1 (en) 2017-09-07
CN104519989A (zh) 2015-04-15
HK1209381A1 (en) 2016-04-01
AU2017216553B2 (en) 2019-06-27
AU2013283409A1 (en) 2015-01-22
MX354719B (es) 2018-03-16
MX2014015717A (es) 2015-08-05
IN2014DN10714A (2) 2015-09-04

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