CA2876903C - Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria - Google Patents

Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria Download PDF

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Publication number
CA2876903C
CA2876903C CA2876903A CA2876903A CA2876903C CA 2876903 C CA2876903 C CA 2876903C CA 2876903 A CA2876903 A CA 2876903A CA 2876903 A CA2876903 A CA 2876903A CA 2876903 C CA2876903 C CA 2876903C
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Prior art keywords
calibration
particles
image
intensity
particle
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CA2876903A
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English (en)
French (fr)
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CA2876903A1 (en
Inventor
Matthew S. Fisher
Nicolas Arab
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Luminex Corp
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Luminex Corp
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Publication of CA2876903A1 publication Critical patent/CA2876903A1/en
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Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Image Analysis (AREA)
  • Image Processing (AREA)
CA2876903A 2012-06-15 2013-06-14 Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria Active CA2876903C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660270P 2012-06-15 2012-06-15
US61/660,270 2012-06-15
PCT/US2013/046035 WO2013188857A2 (en) 2012-06-15 2013-06-14 Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria

Publications (2)

Publication Number Publication Date
CA2876903A1 CA2876903A1 (en) 2013-12-19
CA2876903C true CA2876903C (en) 2020-07-14

Family

ID=49755971

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2876903A Active CA2876903C (en) 2012-06-15 2013-06-14 Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria

Country Status (6)

Country Link
US (3) US9245169B2 (enExample)
EP (1) EP2861969B1 (enExample)
JP (1) JP6105061B2 (enExample)
CN (1) CN104541152B (enExample)
CA (1) CA2876903C (enExample)
WO (1) WO2013188857A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127080A1 (en) * 2015-02-06 2016-08-11 Life Technologies Corporation System and methods for calibrating binding dyes
GB2571743A (en) * 2018-03-07 2019-09-11 Pop Bio Ltd A method of capturing image data of a luminescent sample and apparatus for the same
CN110361304B (zh) * 2019-06-20 2021-10-01 南开大学 基于pmf3模型和ams数据估算不同生成路径对颗粒物中二次无机粒子贡献的方法
WO2022093931A1 (en) * 2020-10-30 2022-05-05 Becton, Dickinson And Company Method and systems for characterizing and encoding a light detection system
CN112504934B (zh) * 2020-11-23 2021-09-21 中国水利水电科学研究院 一种混凝土坝渗流渗压预测和监控阈值确定方法

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US3824393A (en) * 1971-08-25 1974-07-16 American Express Invest System for differential particle counting
ATE496288T1 (de) 1995-10-11 2011-02-15 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6632526B1 (en) 1997-10-14 2003-10-14 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
CA2318779C (en) 1998-01-22 2009-08-25 Luminex Corporation Microparticles with multiple fluorescent signals
CA2640578A1 (en) 1998-05-14 1999-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
AU4559600A (en) * 1999-04-29 2000-11-17 Evotec Biosystems Ag A method of characterizing fluorescent molecules or other particles using generating functions
EP1204869B1 (en) 1999-08-17 2008-10-22 Luminex Corporation Method for analyzing a number of samples from a variety of sources for a single analyte
AU6779200A (en) 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US7274809B2 (en) 2002-08-29 2007-09-25 Perceptronix Medical, Inc. And British Columbia Cancer Agency Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer
US7175810B2 (en) * 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
US7747304B2 (en) * 2003-04-15 2010-06-29 Koninklijke Philips Electronics N.V. Arrangement and method for the spatially resolved determination of state variables in an examination area
CN1524925A (zh) * 2003-09-18 2004-09-01 吉林大学 荧光磁性纳米复合物及其制备方法和应用
JP5059740B2 (ja) * 2005-02-09 2012-10-31 エス３アイ， エル エル シィ 粒子を検出、分類及び同定する方法及びシステム
EP4071458B1 (en) * 2005-09-21 2025-11-05 Luminex Corporation Methods and systems for image data processing
US8187885B2 (en) * 2009-05-07 2012-05-29 Nodality, Inc. Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US8274656B2 (en) * 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device

Also Published As

Publication number Publication date
EP2861969A4 (en) 2016-03-09
CN104541152A (zh) 2015-04-22
JP2015523660A (ja) 2015-08-13
JP6105061B2 (ja) 2017-03-29
US20160232396A1 (en) 2016-08-11
HK1209482A1 (en) 2016-04-01
WO2013188857A3 (en) 2014-02-13
US20180268191A1 (en) 2018-09-20
EP2861969A2 (en) 2015-04-22
US20130336568A1 (en) 2013-12-19
CA2876903A1 (en) 2013-12-19
WO2013188857A2 (en) 2013-12-19
US10733418B2 (en) 2020-08-04
EP2861969B1 (en) 2022-08-03
US9984279B2 (en) 2018-05-29
US9245169B2 (en) 2016-01-26
CN104541152B (zh) 2017-08-25

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