CA2865040C - Cyclic diaminopyrimidine derivatives - Google Patents

Cyclic diaminopyrimidine derivatives Download PDF

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Publication number
CA2865040C
CA2865040C CA2865040A CA2865040A CA2865040C CA 2865040 C CA2865040 C CA 2865040C CA 2865040 A CA2865040 A CA 2865040A CA 2865040 A CA2865040 A CA 2865040A CA 2865040 C CA2865040 C CA 2865040C
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compound
formula
denotes
compounds
disease
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French (fr)
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CA2865040A1 (en
Inventor
Henry Yu
Lizbeth Celeste DESELM
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
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    • A61P25/16Anti-Parkinson drugs
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/04Antibacterial agents
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    • A61P33/06Antimalarials
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicinal Chemistry (AREA)
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  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
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CA2865040A 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives Active CA2865040C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601101P 2012-02-21 2012-02-21
US61/601,101 2012-02-21
PCT/US2012/070252 WO2013126132A1 (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

Publications (2)

Publication Number Publication Date
CA2865040A1 CA2865040A1 (en) 2013-08-29
CA2865040C true CA2865040C (en) 2020-07-14

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CA2865040A Active CA2865040C (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

Country Status (10)

Country Link
US (1) US9073944B2 (enExample)
EP (1) EP2817306B1 (enExample)
JP (1) JP6059260B2 (enExample)
CN (1) CN104254531B (enExample)
AR (1) AR090103A1 (enExample)
AU (1) AU2012370450B2 (enExample)
CA (1) CA2865040C (enExample)
ES (1) ES2552518T3 (enExample)
IL (1) IL233986A (enExample)
WO (1) WO2013126132A1 (enExample)

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PE20191541A1 (es) 2016-12-22 2019-10-23 Calithera Biosciences Inc Composiciones y metodos para inhibir la accion de la arginasa
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
JP2023513793A (ja) * 2020-02-14 2023-04-03 ソーク インスティテュート フォー バイオロジカル スタディーズ 大環状ulk1/2阻害剤
WO2022073994A1 (en) * 2020-10-05 2022-04-14 Merck Patent Gmbh Lmp7-selective inhibitors for the treatment of blood disorders and solid tumors
JP7556310B2 (ja) * 2021-02-26 2024-09-26 スズキ株式会社 電動車両
CA3212583A1 (en) 2021-03-27 2022-10-06 Daniel Gooding Compositions having improved bioavailability of therapeutics
US20250000859A1 (en) 2021-08-25 2025-01-02 Alesta Therapeutics BV Use of gcn2 inhibitors in treating cancer
CA3245873A1 (en) * 2022-03-14 2023-09-21 Trx Biosciences Ltd Compositions with improved bioavailability of therapeutic agents and their uses
WO2024017251A1 (zh) * 2022-07-18 2024-01-25 江苏恒瑞医药股份有限公司 抑制并诱导egfr降解的大环类化合物、其制备方法及其在医药上的应用

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JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド 4―アニリノキナゾリン誘導体
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
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Publication number Publication date
EP2817306A1 (en) 2014-12-31
CN104254531B (zh) 2017-05-03
AU2012370450B2 (en) 2017-02-02
AR090103A1 (es) 2014-10-22
EP2817306B1 (en) 2015-09-16
WO2013126132A1 (en) 2013-08-29
CN104254531A (zh) 2014-12-31
AU2012370450A1 (en) 2014-10-02
US9073944B2 (en) 2015-07-07
JP6059260B2 (ja) 2017-01-11
US20150025066A1 (en) 2015-01-22
CA2865040A1 (en) 2013-08-29
JP2015508099A (ja) 2015-03-16
IL233986A (en) 2017-10-31
ES2552518T3 (es) 2015-11-30

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