AU2012370450B2 - Cyclic diaminopyrimidine derivatives - Google Patents

Cyclic diaminopyrimidine derivatives Download PDF

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Publication number
AU2012370450B2
AU2012370450B2 AU2012370450A AU2012370450A AU2012370450B2 AU 2012370450 B2 AU2012370450 B2 AU 2012370450B2 AU 2012370450 A AU2012370450 A AU 2012370450A AU 2012370450 A AU2012370450 A AU 2012370450A AU 2012370450 B2 AU2012370450 B2 AU 2012370450B2
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disease
formula
conditions
compound
denotes
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AU2012370450A1 (en
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Lizbeth Celeste DESELM
Henry Yu
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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AU2012370450A 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives Ceased AU2012370450B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601101P 2012-02-21 2012-02-21
US61/601,101 2012-02-21
PCT/US2012/070252 WO2013126132A1 (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

Publications (2)

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AU2012370450A1 AU2012370450A1 (en) 2014-10-02
AU2012370450B2 true AU2012370450B2 (en) 2017-02-02

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AU2012370450A Ceased AU2012370450B2 (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

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US (1) US9073944B2 (enExample)
EP (1) EP2817306B1 (enExample)
JP (1) JP6059260B2 (enExample)
CN (1) CN104254531B (enExample)
AR (1) AR090103A1 (enExample)
AU (1) AU2012370450B2 (enExample)
CA (1) CA2865040C (enExample)
ES (1) ES2552518T3 (enExample)
IL (1) IL233986A (enExample)
WO (1) WO2013126132A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106999561A (zh) 2014-07-18 2017-08-01 阿德瓦希斯股份有限公司 用于治疗前列腺癌的pd‑1拮抗剂和基于李斯特菌的疫苗的组合
ES2970715T3 (es) 2016-12-22 2024-05-30 Prec Pharmaceuticals Inc Composiciones y métodos para inhibir la actividad de la arginasa
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
KR20220153582A (ko) * 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
EP4225281A1 (en) * 2020-10-05 2023-08-16 Merck Patent GmbH Lmp7-selective inhibitors for the treatment of blood disorders and solid tumors
JP7556310B2 (ja) * 2021-02-26 2024-09-26 スズキ株式会社 電動車両
IL306029A (en) 2021-03-27 2023-11-01 Trx Biosciences Ltd Preparations with improved bioavailability of medical treatments
US20250000859A1 (en) 2021-08-25 2025-01-02 Alesta Therapeutics BV Use of gcn2 inhibitors in treating cancer
JP2025509680A (ja) * 2022-03-14 2025-04-11 ティーアールエックス バイオサイエンシズ リミテッド 治療薬のバイオアベイラビリティを改善した組成物およびその使用
TW202404979A (zh) * 2022-07-18 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 抑制並誘導ｅｇｆｒ降解的大環類化合物、其製備方法及其在醫藥上的應用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007111720A2 (en) * 2005-12-06 2007-10-04 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
AU719327B2 (en) 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
EP1289952A1 (en) 2000-05-31 2003-03-12 AstraZeneca AB Indole derivatives with vascular damaging activity
MXPA02012905A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como agentes de dano vascular..
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
ZA200501536B (en) * 2002-08-14 2006-10-25 Vertex Pharma Protein kinase inhibitors and uses thereof
CN1860118A (zh) * 2003-07-29 2006-11-08 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
HRP20130602T1 (en) * 2003-07-30 2013-07-31 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
GB0321710D0 (en) * 2003-09-16 2003-10-15 Novartis Ag Organic compounds
DK1984357T3 (da) * 2006-02-17 2014-01-13 Rigel Pharmaceuticals Inc 2,4-pyrimidindiaminforbindelser til behandling eller forebyggelse af autoimmunsygdomme
US8163902B2 (en) * 2006-11-21 2012-04-24 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
MX2011002470A (es) 2008-09-08 2011-04-05 Merck Patent Gmbh Pirimidinas macrociclicas como inhibidores de aurora cinasa.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007111720A2 (en) * 2005-12-06 2007-10-04 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers

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CA2865040A1 (en) 2013-08-29
AR090103A1 (es) 2014-10-22
AU2012370450A1 (en) 2014-10-02
WO2013126132A1 (en) 2013-08-29
CN104254531A (zh) 2014-12-31
ES2552518T3 (es) 2015-11-30
CA2865040C (en) 2020-07-14
JP2015508099A (ja) 2015-03-16
EP2817306B1 (en) 2015-09-16
JP6059260B2 (ja) 2017-01-11
CN104254531B (zh) 2017-05-03
US20150025066A1 (en) 2015-01-22
IL233986A (en) 2017-10-31
US9073944B2 (en) 2015-07-07
EP2817306A1 (en) 2014-12-31

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