CA2865037A1 - Methods of detecting braf mutations in cancer - Google Patents

Methods of detecting braf mutations in cancer Download PDF

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Publication number
CA2865037A1
CA2865037A1 CA2865037A CA2865037A CA2865037A1 CA 2865037 A1 CA2865037 A1 CA 2865037A1 CA 2865037 A CA2865037 A CA 2865037A CA 2865037 A CA2865037 A CA 2865037A CA 2865037 A1 CA2865037 A1 CA 2865037A1
Authority
CA
Canada
Prior art keywords
cancer
seq
hcl
braf
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2865037A
Other languages
English (en)
French (fr)
Inventor
Enrico TIACCI
Brunangelo Falini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiff Oncology Inc
Original Assignee
Trovagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trovagene Inc filed Critical Trovagene Inc
Publication of CA2865037A1 publication Critical patent/CA2865037A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2865037A 2011-10-24 2012-10-23 Methods of detecting braf mutations in cancer Abandoned CA2865037A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550504P 2011-10-24 2011-10-24
US61/550,504 2011-10-24
PCT/US2012/061501 WO2013062976A1 (en) 2011-10-24 2012-10-23 Methods of detecting braf mutations in cancer

Publications (1)

Publication Number Publication Date
CA2865037A1 true CA2865037A1 (en) 2013-05-02

Family

ID=47138195

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2865037A Abandoned CA2865037A1 (en) 2011-10-24 2012-10-23 Methods of detecting braf mutations in cancer

Country Status (6)

Country Link
US (1) US20130130264A1 (enExample)
EP (1) EP2771486A1 (enExample)
JP (1) JP2014532407A (enExample)
AU (1) AU2012329042A1 (enExample)
CA (1) CA2865037A1 (enExample)
WO (1) WO2013062976A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012253525B2 (en) * 2011-05-10 2016-09-22 Brunangelo Falini Hairy cell leukemia biomarkers and methods of using same
CA2926722A1 (en) * 2013-10-19 2015-04-23 Trovagene, Inc. Detecting mutations in disease over time
WO2015058175A2 (en) * 2013-10-19 2015-04-23 Trovagene, Inc. Detecting and monitoring mutations in histiocytosis
CA2954689A1 (en) * 2014-07-11 2016-01-14 Expression Pathology, Inc. Srm/mrm assay for the serine/threonine-protein kinase b-raf (braf)
CN106755489A (zh) * 2017-01-22 2017-05-31 杭州金溪生物技术有限公司 高灵敏度基因突变检测方法及所用试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020657A1 (en) * 2005-05-20 2007-01-25 Grebe Stefan K Methods for detecting circulating tumor cells
WO2007106534A2 (en) * 2006-03-14 2007-09-20 Harbor-Ucla Research And Education Institute Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides
EP2337865B1 (en) * 2008-10-20 2014-11-19 Roche Diagnostics GmbH Allele-specific amplification using a primer with a modified nucleotide
AU2012253525B2 (en) * 2011-05-10 2016-09-22 Brunangelo Falini Hairy cell leukemia biomarkers and methods of using same

Also Published As

Publication number Publication date
WO2013062976A1 (en) 2013-05-02
AU2012329042A1 (en) 2014-06-12
EP2771486A1 (en) 2014-09-03
JP2014532407A (ja) 2014-12-08
US20130130264A1 (en) 2013-05-23

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20181023