CA2863536A1 - Human antibodies to clostridium difficile toxins - Google Patents
Human antibodies to clostridium difficile toxins Download PDFInfo
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- CA2863536A1 CA2863536A1 CA2863536A CA2863536A CA2863536A1 CA 2863536 A1 CA2863536 A1 CA 2863536A1 CA 2863536 A CA2863536 A CA 2863536A CA 2863536 A CA2863536 A CA 2863536A CA 2863536 A1 CA2863536 A1 CA 2863536A1
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Classifications
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- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Epidemiology (AREA)
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- Microbiology (AREA)
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- Nutrition Science (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (7)
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| US201261605914P | 2012-03-02 | 2012-03-02 | |
| US61/605,914 | 2012-03-02 | ||
| US201261608255P | 2012-03-08 | 2012-03-08 | |
| US61/608,255 | 2012-03-08 | ||
| US201261717404P | 2012-10-23 | 2012-10-23 | |
| US61/717,404 | 2012-10-23 | ||
| PCT/US2013/028630 WO2013130981A1 (en) | 2012-03-02 | 2013-03-01 | Human antibodies to clostridium difficile toxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2863536A1 true CA2863536A1 (en) | 2013-09-06 |
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| CA2863536A Abandoned CA2863536A1 (en) | 2012-03-02 | 2013-03-01 | Human antibodies to clostridium difficile toxins |
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| US (2) | US9399674B2 (enExample) |
| EP (1) | EP2820044A1 (enExample) |
| JP (2) | JP2015509962A (enExample) |
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| UY (1) | UY34652A (enExample) |
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| EP3028565B1 (en) | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| EP2757875B2 (en) | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9181632B1 (en) | 2013-09-09 | 2015-11-10 | Merck Sharp & Dohme Corp. | C.difficile toxin B CROP domain peptides, antibodies and complexes thereof |
| WO2015049517A2 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| ES2870506T3 (es) | 2015-02-19 | 2021-10-27 | Immune Biosolutions Inc | Antígeno y anticuerpo del epítopo de las toxinas a y/o b de clostridium difficile, y sus usos farmacéuticos |
| JP2018517670A (ja) * | 2015-04-15 | 2018-07-05 | メディミューン，エルエルシー | クロストリジウム・ディフィシル（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）感染および関連疾患の治療方法 |
| EP3445783A2 (en) | 2016-04-18 | 2019-02-27 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| WO2017189964A2 (en) * | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3753952A4 (en) * | 2017-12-13 | 2022-04-13 | XDCExplorer (Shanghai) Co., Ltd. | EGFRVIII ANTIBODY AND CONJUGATE, AND METHODS FOR ITS PRODUCTION AND USE |
| WO2020060771A1 (en) * | 2018-09-18 | 2020-03-26 | Vanderbilt University | Human monoclonal antibodies to staphylococcal aureus isd proteins and uses thereof |
| US20200148762A1 (en) * | 2018-11-09 | 2020-05-14 | Avamab Pharma Inc. | Methods for regulating endogenous production of antibodies against infectious diseases |
| CN111793130B (zh) * | 2019-03-20 | 2021-09-14 | 华中农业大学 | 一株副猪嗜血杆菌CdtB杂交瘤细胞及单克隆抗体应用 |
| KR102376876B1 (ko) | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
| WO2021219786A1 (en) | 2020-04-30 | 2021-11-04 | Gottfried Himmler | Anti-toxin secretory iga2 preparation |
| WO2025029561A2 (en) * | 2023-07-28 | 2025-02-06 | University Of South Florida | Vaccine containing rbd2 of cdtb component from binary toxin cdt of clostridioides difficile |
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| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US5358868A (en) | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| US5221618A (en) | 1987-11-24 | 1993-06-22 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5332583A (en) | 1987-11-24 | 1994-07-26 | Connaught Laboratories Limited | Vaccine containing genetically-detoxified pertussis holotoxin |
| US5244657A (en) | 1987-11-24 | 1993-09-14 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5224657A (en) | 1989-05-23 | 1993-07-06 | Kabushiki Kaisha Toshiba | Cryogenic refrigerator |
| US5231003A (en) | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
| JP4312259B2 (ja) * | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| DE19739685A1 (de) * | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
| DE69829400T2 (de) | 1997-10-20 | 2006-04-13 | Acambis, Inc., Cambridge | Passive immunisierung gegen durch clostridium difficile verursachte krankheit |
| EP1568378B1 (en) | 1997-10-20 | 2016-03-16 | Sanofi Pasteur Biologics, LLC | Immunization against Clostridium difficile disease |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| GB0309126D0 (en) | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| CN1809591A (zh) * | 2003-05-21 | 2006-07-26 | 米德列斯公司 | 针对炭疽芽孢杆菌保护性抗原的人单克隆抗体 |
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2013
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- 2013-03-01 JP JP2014560093A patent/JP2015509962A/ja active Pending
- 2013-03-01 SG SG11201405087PA patent/SG11201405087PA/en unknown
- 2013-03-01 EP EP13708641.9A patent/EP2820044A1/en not_active Withdrawn
- 2013-03-01 UY UY0001034652A patent/UY34652A/es unknown
- 2013-03-01 WO PCT/US2013/028630 patent/WO2013130981A1/en not_active Ceased
- 2013-03-01 HK HK15100241.0A patent/HK1200463A1/xx unknown
- 2013-03-01 TW TW102107190A patent/TWI592422B/zh not_active IP Right Cessation
- 2013-03-01 CN CN201380012035.0A patent/CN104203976A/zh active Pending
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- 2013-03-01 SG SG10201610123UA patent/SG10201610123UA/en unknown
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- 2013-03-01 NZ NZ628943A patent/NZ628943A/en not_active IP Right Cessation
- 2013-03-01 RU RU2017127772A patent/RU2017127772A/ru not_active Application Discontinuation
- 2013-03-01 AR ARP130100670A patent/AR090219A1/es unknown
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- 2013-03-01 MX MX2014010527A patent/MX2014010527A/es unknown
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2014
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2820044A1 (en) | 2015-01-07 |
| CN108101983A (zh) | 2018-06-01 |
| CN104203976A (zh) | 2014-12-10 |
| AU2013203942A1 (en) | 2013-09-19 |
| WO2013130981A1 (en) | 2013-09-06 |
| AR090219A1 (es) | 2014-10-29 |
| MX2014010527A (es) | 2014-10-14 |
| US9399674B2 (en) | 2016-07-26 |
| TWI592422B (zh) | 2017-07-21 |
| RU2017127772A (ru) | 2019-02-04 |
| AU2013203942B2 (en) | 2016-03-10 |
| UY34652A (es) | 2013-09-02 |
| HK1200463A1 (en) | 2015-08-07 |
| BR112014021251A2 (pt) | 2017-06-27 |
| KR20140130709A (ko) | 2014-11-11 |
| SG11201405087PA (en) | 2014-09-26 |
| IL233884A0 (en) | 2014-09-30 |
| SG10201610123UA (en) | 2017-01-27 |
| NZ714516A (en) | 2017-06-30 |
| JP2015509962A (ja) | 2015-04-02 |
| TW201350501A (zh) | 2013-12-16 |
| NZ628943A (en) | 2016-08-26 |
| AU2013203942A8 (en) | 2016-08-11 |
| JP2018029625A (ja) | 2018-03-01 |
| RU2628305C2 (ru) | 2017-08-15 |
| AU2016203511A1 (en) | 2016-06-16 |
| RU2014139552A (ru) | 2016-04-20 |
| US20160264650A1 (en) | 2016-09-15 |
| US20130230531A1 (en) | 2013-09-05 |
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