CA2863417C - Innate immune proteins as biomarkers for cns injury - Google Patents

Innate immune proteins as biomarkers for cns injury Download PDF

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Publication number
CA2863417C
CA2863417C CA2863417A CA2863417A CA2863417C CA 2863417 C CA2863417 C CA 2863417C CA 2863417 A CA2863417 A CA 2863417A CA 2863417 A CA2863417 A CA 2863417A CA 2863417 C CA2863417 C CA 2863417C
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Prior art keywords
injury
protein
patient
inflammasome
level
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CA2863417A
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English (en)
French (fr)
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CA2863417A1 (en
Inventor
Robert W. Keane
W. Dalton Dietrich
Juan Pablo De Rivero Vaccari
Stephanie ADAMCZAK
M. Ross Bullock
Allan LEVI
Michael Y. Wang
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University of Miami
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University of Miami
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2863417A 2012-02-06 2013-02-06 Innate immune proteins as biomarkers for cns injury Active CA2863417C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595254P 2012-02-06 2012-02-06
US61/595,254 2012-02-06
PCT/US2013/024941 WO2013119673A1 (en) 2012-02-06 2013-02-06 Innate immune proteins as biomarkers for cns injury

Publications (2)

Publication Number Publication Date
CA2863417A1 CA2863417A1 (en) 2013-08-15
CA2863417C true CA2863417C (en) 2020-07-28

Family

ID=48947960

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2863417A Active CA2863417C (en) 2012-02-06 2013-02-06 Innate immune proteins as biomarkers for cns injury

Country Status (6)

Country Link
US (4) US20150185232A1 (https=)
EP (1) EP2812697B1 (https=)
JP (1) JP6170071B2 (https=)
CA (1) CA2863417C (https=)
ES (1) ES2630905T3 (https=)
WO (1) WO2013119673A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2015157390A1 (en) * 2014-04-08 2015-10-15 University Of Florida Research Foundation, Incorporated Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system
US11840565B2 (en) 2016-12-29 2023-12-12 University Of Miami Methods and compositions for treating virus-associated inflammation
EP3562506A4 (en) 2016-12-29 2021-01-06 University of Miami METHOD TO MODULATE INFLAMMASOME ACTIVITY AND INFLAMMATION IN THE LUNG
KR101910269B1 (ko) * 2017-02-24 2018-10-19 성균관대학교산학협력단 인간 뇌 조직 유래 신경줄기세포의 고효율 분리 방법
BR112020005445A2 (pt) * 2017-09-20 2020-09-29 University Of Miami método para a detecção de proteínas do inflamassoma como biomarcadores de transtornos neurológicos
WO2019199869A1 (en) * 2018-04-10 2019-10-17 Quanterix Corporation Quantification of biomarkers present in physiological samples
WO2020010273A1 (en) 2018-07-03 2020-01-09 University Of Miami Compositions and methods for treating inflammasome related diseases or conditions
GB201815045D0 (en) 2018-09-14 2018-10-31 Univ Ulster Bispecific antibody targeting IL-1R1 and NLPR3
CN109406795A (zh) * 2018-11-20 2019-03-01 昆明医科大学 一种轻型脑外伤的血清分子诊断标记物及应用
EP3918336A1 (en) * 2019-01-31 2021-12-08 University of Geneva Prospective markers in traumatic brain injury (tbi)
WO2021071934A1 (en) * 2019-10-07 2021-04-15 United States Government As Represented By The Department Of Veterans Affairs Polymeric methylprednisolone conjugates and uses thereof
CA3176521A1 (en) * 2020-04-27 2021-11-04 University Of Miami Compositions and methods for treating inflammasome related diseases or conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022156A2 (en) * 2002-09-04 2004-03-18 Washington University Methods for treating central nervous system damage
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
CN101983337A (zh) * 2008-02-04 2011-03-02 班扬生物标记公司 用于诊断或治疗脑损伤的方法
US8404752B2 (en) * 2008-07-18 2013-03-26 Oxygen Biotherapeutics, Inc. Method of treating traumatic brain injury
US20120177632A1 (en) * 2011-01-10 2012-07-12 Shinohara Mari L Methods of optimizing disease treatment

Also Published As

Publication number Publication date
US20200363432A1 (en) 2020-11-19
EP2812697A1 (en) 2014-12-17
US20230349929A1 (en) 2023-11-02
US12560618B2 (en) 2026-02-24
CA2863417A1 (en) 2013-08-15
EP2812697B1 (en) 2017-03-22
WO2013119673A1 (en) 2013-08-15
ES2630905T3 (es) 2017-08-25
EP2812697A4 (en) 2015-08-26
JP2015508887A (ja) 2015-03-23
JP6170071B2 (ja) 2017-07-26
US20170003303A1 (en) 2017-01-05
US20150185232A1 (en) 2015-07-02

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