CA2862739A1 - Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer - Google Patents
Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer Download PDFInfo
- Publication number
- CA2862739A1 CA2862739A1 CA2862739A CA2862739A CA2862739A1 CA 2862739 A1 CA2862739 A1 CA 2862739A1 CA 2862739 A CA2862739 A CA 2862739A CA 2862739 A CA2862739 A CA 2862739A CA 2862739 A1 CA2862739 A1 CA 2862739A1
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- Prior art keywords
- inhibitor
- egfr
- clusterin
- seq
- carcinoma
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261601786P | 2012-02-22 | 2012-02-22 | |
| US61/601,786 | 2012-02-22 | ||
| PCT/CA2013/000167 WO2013123588A1 (en) | 2012-02-22 | 2013-02-22 | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
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| CA2862739A Abandoned CA2862739A1 (en) | 2012-02-22 | 2013-02-22 | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
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| WO (1) | WO2013123588A1 (cg-RX-API-DMAC7.html) |
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| MX2014010164A (es) | 2012-02-22 | 2014-11-25 | Alethia Biotherapeutics Inc | Co-uso de un inhibidor de clusterina con un inhibidor de egfr para tratar cancer. |
| US10391115B2 (en) | 2014-02-07 | 2019-08-27 | Ajou University Industry-Academic Cooperation Foundation | Anticancer adjuvant composition containing RIP3 expression promoter as active ingredient, method for screening for anticancer adjuvant enhancing sensitivity of anticancer drug by promoting RIP3 expression, and method for monitoring sensitivity of anticancer drug |
| WO2016098041A1 (en) | 2014-12-18 | 2016-06-23 | Saarum Sciences Private Ltd | Establishment and use of an in vitro platform for emt |
| CN105987997B (zh) * | 2015-01-30 | 2017-12-29 | 江苏众红生物工程创药研究院有限公司 | 人组织激肽释放酶1荧光定量检测试纸卡 |
| CN105988004B (zh) * | 2015-01-30 | 2017-12-29 | 江苏众红生物工程创药研究院有限公司 | 人组织激肽释放酶1胶体金定量检测试纸卡 |
| WO2019114793A1 (zh) * | 2017-12-13 | 2019-06-20 | 凯惠科技发展(上海)有限公司 | 一种egfr抗体及其制备方法和应用 |
| WO2020154627A1 (en) * | 2019-01-25 | 2020-07-30 | Promab Biotechnologies, Inc. | Epcam antibody and epcam-car-t cells |
| CN114249832B (zh) * | 2020-09-24 | 2023-11-10 | 博源润生医药（杭州）有限公司 | 一种靶向cpsg4的人源化嵌合抗原受体及表达该嵌合抗原受体的免疫效应细胞及其应用 |
| KR20240014052A (ko) * | 2021-04-27 | 2024-01-31 | 알레시아 바이오쎄라퓨틱스 인코포레이티드 | 면역 세포의 종양내 침윤을 허용하는 방법 |
| CN117903305B (zh) * | 2023-12-05 | 2024-08-27 | 南京欧凯生物科技有限公司 | 针对雌二醇的单克隆抗体、基于其的检测试剂及其应用 |
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| DE3933850A1 (de) | 1989-10-06 | 1991-04-18 | Schering Ag | Zytolyse-inhibitor (zli), eine diese blutplasmaprotein kodierende dna-sequenz, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses proteins |
| EP0614984B2 (en) | 1993-03-05 | 2010-11-03 | Bayer HealthCare LLC | Anti-TNF alpha human monoclonal antibodies |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US6383808B1 (en) | 2000-09-11 | 2002-05-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of clusterin expression |
| US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
| WO2000034469A1 (en) | 1998-12-11 | 2000-06-15 | The Research Foundation Of State University Of New York At Albany | Compositions and methods for altering cell migration |
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2013
- 2013-02-22 MX MX2014010164A patent/MX2014010164A/es unknown
- 2013-02-22 WO PCT/CA2013/000167 patent/WO2013123588A1/en not_active Ceased
- 2013-02-22 EP EP13751181.2A patent/EP2817028A4/en not_active Withdrawn
- 2013-02-22 AU AU2013224591A patent/AU2013224591A1/en not_active Abandoned
- 2013-02-22 NZ NZ626742A patent/NZ626742A/en not_active IP Right Cessation
- 2013-02-22 CN CN201380010493.0A patent/CN104159611A/zh active Pending
- 2013-02-22 JP JP2014557950A patent/JP2015512877A/ja active Pending
- 2013-02-22 EA EA201491568A patent/EA201491568A1/ru unknown
- 2013-02-22 BR BR112014020756A patent/BR112014020756A2/pt not_active IP Right Cessation
- 2013-02-22 CA CA2862739A patent/CA2862739A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| US9822170B2 (en) | 2017-11-21 |
| US20150044220A1 (en) | 2015-02-12 |
| EA201491568A1 (ru) | 2014-11-28 |
| NZ626742A (en) | 2016-06-24 |
| AU2013224591A1 (en) | 2014-07-24 |
| CN104159611A (zh) | 2014-11-19 |
| AU2013224591A9 (en) | 2015-07-23 |
| BR112014020756A2 (pt) | 2017-07-04 |
| WO2013123588A1 (en) | 2013-08-29 |
| EP2817028A1 (en) | 2014-12-31 |
| EP2817028A4 (en) | 2015-11-04 |
| MX2014010164A (es) | 2014-11-25 |
| JP2015512877A (ja) | 2015-04-30 |
| WO2013123588A9 (en) | 2014-09-04 |
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