CA2861695C - Method of isolating human antibodies - Google Patents
Method of isolating human antibodies Download PDFInfo
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- CA2861695C CA2861695C CA2861695A CA2861695A CA2861695C CA 2861695 C CA2861695 C CA 2861695C CA 2861695 A CA2861695 A CA 2861695A CA 2861695 A CA2861695 A CA 2861695A CA 2861695 C CA2861695 C CA 2861695C
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- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C07—ORGANIC CHEMISTRY
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- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
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| US10131709B2 (en) | 2011-12-28 | 2018-11-20 | Immunoqure Ag | Nucleic acid molecules encoding monoclonal antibodies specific for IL-22 |
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| US20140199319A1 (en) * | 2012-12-14 | 2014-07-17 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| CA2917112C (en) | 2013-07-03 | 2022-07-05 | Immunoqure Ag | Human anti-ifn-alpha antibodies |
| WO2015001047A1 (en) | 2013-07-03 | 2015-01-08 | Immunoqure Ag | Method of providing anti-human cytokine antibodies for pharmaceutical use |
| EP3016977B1 (en) * | 2013-07-03 | 2019-10-23 | ImmunoQure AG | Human anti-il-32 antibodies |
| EP2863231A1 (en) * | 2013-10-17 | 2015-04-22 | Institut D'Investigaciones Biomédiques August Pi i Sunyer | Diagnostic method for detecting a GABA(A) related autoimmune disease and related subject-matter |
| KR20170027795A (ko) * | 2014-07-03 | 2017-03-10 | 이뮤노큐어 아게 | 항-사이토카인 항체의 동정을 위한 인간-유래 항-인간 il-20 항체 및 검정 |
| KR102441107B1 (ko) * | 2014-11-07 | 2022-09-13 | 후지쿠라 가세이 가부시키가이샤 | 데옥시하이푸신·신타제 유전자를 지표로서 사용하는 동맥 경화 및 암의 검출 방법 |
| PT3277321T (pt) | 2015-04-01 | 2024-09-17 | Anaptysbio Inc | Anticorpos dirigidos contra a proteína de imunoglobulina de células t e mucina 3 (tim-3) |
| MX2017013080A (es) | 2015-04-15 | 2018-02-09 | Anaptysbio Inc | Anticuerpos dirigidos contra receptor de interleucina 36 (il-36r). |
| CN108350071A (zh) * | 2015-08-17 | 2018-07-31 | 德国神经退行性疾病中心 | 结合到抗N-甲基-D-天冬氨酸(NMDA)受体抗体的结合区的抗体或抗体片段或非Ig支架 |
| FR3050535B1 (fr) * | 2016-04-25 | 2020-11-13 | Hospices Civils Lyon | Anticorps anti il17 |
| US20190183997A1 (en) * | 2016-07-22 | 2019-06-20 | University Of Washington | Identification and production of high affinity igm antibodies and derivatives thereof |
| CA3041685A1 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| KR102671283B1 (ko) | 2017-01-09 | 2024-06-03 | 테사로, 인코포레이티드 | 항tim-3 항체로 암을 치료하는 방법 |
| US11619832B2 (en) | 2018-03-08 | 2023-04-04 | Coopervision International Limited | Identification of contact lens wearers predisposed to contact lens discomfort |
| AU2020205965A1 (en) | 2019-01-07 | 2021-07-01 | Shattuck Labs. Inc. | Heterodimeric proteins for modulating gamma delta T cells |
| US11098093B2 (en) | 2019-01-07 | 2021-08-24 | Shattuck Labs, Inc. | Heterodimeric proteins for modulating gamma delta T cells |
| WO2021250323A1 (en) * | 2020-06-09 | 2021-12-16 | Helsingin Yliopisto | Anti-cox-2 autoantibody as a diagnostic marker, and methods, kits and uses related thereto |
| EP4305190A4 (en) | 2021-03-11 | 2025-03-26 | Iggenix, Inc. | METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION |
| WO2023213400A1 (en) * | 2022-05-05 | 2023-11-09 | Institute For Research In Biomedicine | Antibodies against chemokines, method for identifying said antibodies and uses thereof |
| CN115724983B (zh) * | 2022-10-10 | 2023-09-19 | 宝船生物医药科技(上海)有限公司 | 一种针对抗csf1r单克隆抗体的抗独特型抗体及其应用 |
| TW202540204A (zh) | 2024-01-26 | 2025-10-16 | 西班牙商阿爾米雷爾有限公司 | 雙特異性分子及使用其的治療方法 |
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