CA2858938C - 2- (pyridin-2yl) - 1, 7 - diaza - spiro [4.4] nonane- 6 - one compound as voltage-gated sodium channels modulator - Google Patents
2- (pyridin-2yl) - 1, 7 - diaza - spiro [4.4] nonane- 6 - one compound as voltage-gated sodium channels modulator Download PDFInfo
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- CA2858938C CA2858938C CA2858938A CA2858938A CA2858938C CA 2858938 C CA2858938 C CA 2858938C CA 2858938 A CA2858938 A CA 2858938A CA 2858938 A CA2858938 A CA 2858938A CA 2858938 C CA2858938 C CA 2858938C
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Landscapes
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Applications Claiming Priority (5)
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| US201161579613P | 2011-12-22 | 2011-12-22 | |
| GB1122113.2 | 2011-12-22 | ||
| GBGB1122113.2A GB201122113D0 (en) | 2011-12-22 | 2011-12-22 | Novel compounds |
| US61/579,613 | 2011-12-22 | ||
| PCT/GB2012/053233 WO2013093496A1 (en) | 2011-12-22 | 2012-12-21 | 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4] nonane- 6 -one compound as voltage-gated sodium channels modulator |
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| CA2858938A1 CA2858938A1 (en) | 2013-06-27 |
| CA2858938C true CA2858938C (en) | 2020-03-10 |
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| JP (2) | JP2015502394A (OSRAM) |
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| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| RU2650523C1 (ru) | 2017-07-24 | 2018-04-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Производное пиридоксина для лечения эпилепсии |
| AU2018347349A1 (en) * | 2017-10-10 | 2020-04-23 | Biogen Inc. | Process for preparing spiro derivatives |
| BR112020009361A2 (pt) | 2017-11-17 | 2020-10-13 | Cellix Bio Private Limited | composto de fórmula i, composição farmacêutica para tratar um distúrbio ocular ou complicações do mesmo, método de síntese de composto, método de tratamento de um distúrbio ocular ou complicações do mesmo em um indivíduo que precisa do mesmo e uso de um composto |
| CN113563258A (zh) * | 2021-07-29 | 2021-10-29 | 派普医药(江苏)有限公司 | 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法 |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
| TW202322794A (zh) * | 2021-09-24 | 2023-06-16 | 加拿大商再諾製藥公司 | 做為鈉通道活化劑之吡啶基衍生物 |
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| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| WO1996025405A1 (en) | 1995-02-13 | 1996-08-22 | G.D. Searle & Co. | Substituted isoxazoles for the treatment of inflammation |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| BR9708574A (pt) | 1996-04-12 | 1999-08-03 | Searle & Co | Derivados benzeno sulfonamida substituídos como pródrogas de inibidores cox-2 |
| EA001444B1 (ru) | 1996-07-18 | 2001-04-23 | Мерк Фросст Кэнада Энд Ко./Мерк Фросст Кэнада Э Си | Замещенные пиридины в качестве избирательных ингибиторов циклооксигеназы-2 |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| DE69827419T2 (de) | 1997-09-05 | 2005-10-27 | Glaxo Group Ltd., Greenford | Pharmazeutische Zusammensetzung, enthaltend 2,3-Diaryl-Pyrazolo[1,5-b]Pyridazin Derivate |
| ES2228127T3 (es) | 1998-11-03 | 2005-04-01 | Glaxo Group Limited | Derivados de pirazolopiridina como inhibidores selectivos de cox-2. |
| US6025683A (en) | 1998-12-23 | 2000-02-15 | Stryker Corporation | Motor control circuit for regulating a D.C. motor |
| ATE261444T1 (de) | 1999-02-27 | 2004-03-15 | Glaxo Group Ltd | Pyrazolopyridine |
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| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| WO2007042250A1 (en) | 2005-10-10 | 2007-04-19 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0520578D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| TW200728258A (en) * | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| US7505330B2 (en) * | 2006-08-31 | 2009-03-17 | Micron Technology, Inc. | Phase-change random access memory employing read before write for resistance stabilization |
| AU2008208920A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or R(-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an NK1 |
| GB0701366D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| SI2477964T1 (sl) | 2009-09-14 | 2015-10-30 | Convergence Pharmaceuticals Limited | Postopek za pripravo derivatov alfa-karboksamida |
| US8445696B2 (en) * | 2009-10-14 | 2013-05-21 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
-
2011
- 2011-12-22 GB GBGB1122113.2A patent/GB201122113D0/en not_active Ceased
-
2012
- 2012-12-21 WO PCT/GB2012/053234 patent/WO2013093497A1/en active Application Filing
- 2012-12-21 EP EP12810416.3A patent/EP2797922B1/en not_active Not-in-force
- 2012-12-21 BR BR112014014940A patent/BR112014014940A2/pt not_active Application Discontinuation
- 2012-12-21 KR KR1020147019965A patent/KR20140113692A/ko not_active Withdrawn
- 2012-12-21 JP JP2014548201A patent/JP2015502394A/ja active Pending
- 2012-12-21 SG SG11201403356YA patent/SG11201403356YA/en unknown
- 2012-12-21 US US14/365,391 patent/US9303032B2/en not_active Expired - Fee Related
- 2012-12-21 MX MX2014007637A patent/MX2014007637A/es unknown
- 2012-12-21 US US14/365,372 patent/US9376436B2/en not_active Expired - Fee Related
- 2012-12-21 IN IN1469MUN2014 patent/IN2014MN01469A/en unknown
- 2012-12-21 CN CN201280070485.0A patent/CN104271581B/zh not_active Expired - Fee Related
- 2012-12-21 EP EP12810417.1A patent/EP2794612B1/en not_active Not-in-force
- 2012-12-21 JP JP2014548202A patent/JP2015502395A/ja active Pending
- 2012-12-21 CA CA2858938A patent/CA2858938C/en active Active
- 2012-12-21 EA EA201491251A patent/EA026500B1/ru unknown
- 2012-12-21 HK HK15104075.3A patent/HK1203501A1/xx unknown
- 2012-12-21 ES ES12810416.3T patent/ES2581327T3/es active Active
- 2012-12-21 WO PCT/GB2012/053233 patent/WO2013093496A1/en active Application Filing
- 2012-12-21 HK HK15103930.0A patent/HK1203492A1/xx unknown
- 2012-12-21 AU AU2012356386A patent/AU2012356386A1/en not_active Abandoned
-
2014
- 2014-06-10 ZA ZA2014/04269A patent/ZA201404269B/en unknown
- 2014-06-18 IL IL233215A patent/IL233215A0/en unknown
-
2016
- 2016-02-25 US US15/053,445 patent/US20160185758A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201404269B (en) | 2016-06-29 |
| KR20140113692A (ko) | 2014-09-24 |
| WO2013093496A1 (en) | 2013-06-27 |
| MX2014007637A (es) | 2014-09-26 |
| GB201122113D0 (en) | 2012-02-01 |
| US20150225400A1 (en) | 2015-08-13 |
| US9303032B2 (en) | 2016-04-05 |
| EA201491251A1 (ru) | 2014-11-28 |
| CA2858938A1 (en) | 2013-06-27 |
| US20160185758A1 (en) | 2016-06-30 |
| IN2014MN01469A (OSRAM) | 2015-04-17 |
| EP2797922A1 (en) | 2014-11-05 |
| BR112014014940A2 (pt) | 2017-06-13 |
| JP2015502394A (ja) | 2015-01-22 |
| EA026500B1 (ru) | 2017-04-28 |
| JP2015502395A (ja) | 2015-01-22 |
| WO2013093497A1 (en) | 2013-06-27 |
| HK1203501A1 (en) | 2015-10-30 |
| IL233215A0 (en) | 2014-08-31 |
| HK1203492A1 (en) | 2015-10-30 |
| SG11201403356YA (en) | 2014-07-30 |
| US20140350040A1 (en) | 2014-11-27 |
| EP2794612B1 (en) | 2016-04-06 |
| ES2581327T3 (es) | 2016-09-05 |
| CN104271581A (zh) | 2015-01-07 |
| AU2012356386A1 (en) | 2014-07-10 |
| CN104271581B (zh) | 2016-08-31 |
| EP2794612A1 (en) | 2014-10-29 |
| US9376436B2 (en) | 2016-06-28 |
| EP2797922B1 (en) | 2016-04-06 |
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