CA2858799A1 - Tricyclic boron compounds for antimicrobial therapy - Google Patents

Tricyclic boron compounds for antimicrobial therapy Download PDF

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Publication number
CA2858799A1
CA2858799A1 CA2858799A CA2858799A CA2858799A1 CA 2858799 A1 CA2858799 A1 CA 2858799A1 CA 2858799 A CA2858799 A CA 2858799A CA 2858799 A CA2858799 A CA 2858799A CA 2858799 A1 CA2858799 A1 CA 2858799A1
Authority
CA
Canada
Prior art keywords
compound
compounds
mixture
hci
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2858799A
Other languages
English (en)
French (fr)
Inventor
Mikhail Fedorovich Gordeev
Jinqian Liu
Zhengyu Yuan
Xinghai Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MICURX PHARMACEUTICALS Inc
Original Assignee
MICURX PHARMACEUTICALS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MICURX PHARMACEUTICALS Inc filed Critical MICURX PHARMACEUTICALS Inc
Publication of CA2858799A1 publication Critical patent/CA2858799A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2858799A 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy Abandoned CA2858799A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579271P 2011-12-22 2011-12-22
US61/579,271 2011-12-22
PCT/IB2012/002880 WO2013093615A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Publications (1)

Publication Number Publication Date
CA2858799A1 true CA2858799A1 (en) 2013-06-27

Family

ID=47664367

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2858799A Abandoned CA2858799A1 (en) 2011-12-22 2012-12-20 Tricyclic boron compounds for antimicrobial therapy

Country Status (7)

Country Link
US (1) US8530452B2 (OSRAM)
EP (1) EP2793901A1 (OSRAM)
JP (1) JP6031122B2 (OSRAM)
KR (1) KR20140114380A (OSRAM)
CN (1) CN104136032B (OSRAM)
CA (1) CA2858799A1 (OSRAM)
WO (1) WO2013093615A1 (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
UY35287A (es) * 2013-01-30 2014-08-29 Dow Agrosciences Llc Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas.
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
KR101636431B1 (ko) * 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
EP3030519B1 (en) 2013-08-09 2022-01-05 Glaxosmithkline Intellectual Property (No. 2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
EP3164404B1 (en) * 2014-07-01 2019-04-03 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
CN104177226A (zh) * 2014-07-31 2014-12-03 河北国蓬化工有限公司 一种聚醚用催化剂的制备方法
MA41494B1 (fr) 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
KR101925338B1 (ko) 2016-12-22 2018-12-05 엘에스산전 주식회사 전력기기 진단 장치
WO2021029836A1 (en) 2019-08-09 2021-02-18 Safaş Saf Plasti̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Boron-modified flexible polyurethane foam for hygiene and a method of production therefor
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
JP2025520237A (ja) 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
WO2025140370A1 (zh) * 2023-12-27 2025-07-03 上海盟科药业股份有限公司 硼化合物前药的盐型、晶型及其药物组合物和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US7465836B2 (en) 2003-06-16 2008-12-16 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
BRPI0708051A2 (pt) * 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc moléculas pequenas contendo boro como agentes antiflamatórios
JP2009536660A (ja) * 2006-05-02 2009-10-15 アナコール ファーマシューティカルズ，インコーポレイテッド 加水分解耐性ホウ素含有治療剤及びその使用方法
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
WO2009140309A2 (en) 2008-05-12 2009-11-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US20110259250A1 (en) 2008-08-21 2011-10-27 Mcknight James T Systems And Methods For Converting Biomass In The Field To A Combustible Fluid For Direct Replacement Or Supplement To Liquid Fossil Fuels
KR20110111407A (ko) 2008-12-17 2011-10-11 아나코르 파마슈티칼스 인코포레이티드 (ｓ)-３-아미노메틸-７-(３-히드록시-프로폭시)-３ｈ-벤조〔ｃ〕〔１,２〕옥사보롤-１-올의 다형태
WO2011017125A1 (en) 2009-07-28 2011-02-10 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
WO2011127143A1 (en) 2010-04-07 2011-10-13 Glaxosmithkline Llc Process for preparing benzoxaboroles
HRP20211762T1 (hr) * 2010-09-07 2022-02-18 Anacor Pharmaceuticals, Inc. Derivati benzoksaborola za liječenje bakterijskih infekcija

Also Published As

Publication number Publication date
US8530452B2 (en) 2013-09-10
JP6031122B2 (ja) 2016-11-24
WO2013093615A1 (en) 2013-06-27
CN104136032B (zh) 2018-11-13
KR20140114380A (ko) 2014-09-26
EP2793901A1 (en) 2014-10-29
US20130165411A1 (en) 2013-06-27
CN104136032A (zh) 2014-11-05
JP2015502974A (ja) 2015-01-29

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20171220

FZDE Discontinued

Effective date: 20200831

FZDE Discontinued

Effective date: 20200831