CA2858080C - Method for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices - Google Patents
Method for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices Download PDFInfo
- Publication number
- CA2858080C CA2858080C CA2858080A CA2858080A CA2858080C CA 2858080 C CA2858080 C CA 2858080C CA 2858080 A CA2858080 A CA 2858080A CA 2858080 A CA2858080 A CA 2858080A CA 2858080 C CA2858080 C CA 2858080C
- Authority
- CA
- Canada
- Prior art keywords
- flow channel
- blood
- blood flow
- oxygen
- implementations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 87
- 239000008280 blood Substances 0.000 title claims abstract description 87
- 239000012528 membrane Substances 0.000 title claims description 37
- 238000000034 method Methods 0.000 title abstract description 21
- 210000004072 lung Anatomy 0.000 title description 2
- 230000037452 priming Effects 0.000 title description 2
- 239000012530 fluid Substances 0.000 claims abstract description 30
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 20
- 230000001706 oxygenating effect Effects 0.000 claims abstract description 13
- 230000017531 blood circulation Effects 0.000 claims description 60
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 49
- 239000001301 oxygen Substances 0.000 claims description 49
- 229910052760 oxygen Inorganic materials 0.000 claims description 49
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 7
- 239000001569 carbon dioxide Substances 0.000 claims description 7
- 239000003146 anticoagulant agent Substances 0.000 claims description 5
- 229940127219 anticoagulant drug Drugs 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- 210000003743 erythrocyte Anatomy 0.000 abstract description 5
- 239000000835 fiber Substances 0.000 description 4
- -1 polydimethylsiloxane Polymers 0.000 description 4
- 229920000307 polymer substrate Polymers 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 229920000229 biodegradable polyester Polymers 0.000 description 1
- 239000004622 biodegradable polyester Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229910002090 carbon oxide Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567104P | 2011-12-05 | 2011-12-05 | |
| US61/567,104 | 2011-12-05 | ||
| PCT/US2012/067971 WO2013086011A1 (en) | 2011-12-05 | 2012-12-05 | Method for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2858080A1 CA2858080A1 (en) | 2013-06-13 |
| CA2858080C true CA2858080C (en) | 2020-12-01 |
Family
ID=47352068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2858080A Active CA2858080C (en) | 2011-12-05 | 2012-12-05 | Method for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9180239B2 (enExample) |
| EP (1) | EP2788042B1 (enExample) |
| JP (1) | JP6395608B2 (enExample) |
| CN (1) | CN104053461A (enExample) |
| AU (1) | AU2012347922B2 (enExample) |
| CA (1) | CA2858080C (enExample) |
| ES (1) | ES2700249T3 (enExample) |
| IN (1) | IN2014CN04342A (enExample) |
| WO (1) | WO2013086011A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| JP2013534461A (ja) * | 2010-05-26 | 2013-09-05 | ザ チャールズ スターク ドレイパー ラボラトリー インク | 微細加工された人工肺補助装置ならびにその使用および製造の方法 |
| CA3205441A1 (en) * | 2013-02-28 | 2014-09-04 | Hemanext Inc. | Gas depletion and gas addition devices for blood treatment |
| JP2016534839A (ja) | 2013-09-16 | 2016-11-10 | ジョンソン・アンド・ジョンソン・イノベーション・エルエルシーＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｉｎｎｏｖａｔｉｏｎ ＬＬＣ | 境界層分離を組み込む、マイクロ流体器官補助装置 |
| WO2015164618A1 (en) | 2014-04-23 | 2015-10-29 | The Charles Stark Draper Laboratory, Inc. | Blood oxygenator |
| BR122020024355B1 (pt) * | 2014-10-14 | 2023-03-14 | Becton, Dickinson And Company | Dispositivo de mistura e transferência de espécime adaptado para receber uma amostra |
| BR112017019279B1 (pt) | 2015-03-10 | 2022-02-08 | Hemanext Inc | Dispositivos de depleção de oxigênio e armazenamento de sangue e método para preparar sangue para armazenamento, método para reduzir o oxigênio a partir do sangue total e método de preparação de um recipiente de sangue flexível interno |
| MX2017013524A (es) | 2015-04-23 | 2018-05-22 | New Health Sciences Inc | Recipientes para el almacenamiento anaerobico de sangre. |
| EP4623991A3 (en) | 2015-05-18 | 2025-12-17 | Hemanext Inc. | Methods for the storage of whole blood, and compositions thereof |
| CA3025353A1 (en) | 2016-05-27 | 2017-11-30 | The Charles Stark Draper Laboratory, Inc. | Biomimetic microfluidic device for high efficiency carbon dioxide removal from patients at low blood flow rates |
| ES2910948T3 (es) | 2016-05-27 | 2022-05-17 | Hemanext Inc | Almacenamiento anaeróbico de sangre y procedimiento de inactivación de patógenos |
| US11988471B2 (en) * | 2021-03-27 | 2024-05-21 | Massachusetts Institute Of Technology | Devices and methods for fabrication of components of a multiscale porous high-temperature heat exchanger |
| CN116019995B (zh) * | 2022-12-26 | 2025-09-02 | 清华大学 | 微流控人工肺及其制造方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2876769A (en) | 1955-10-11 | 1959-03-10 | Cordova Jose Juan | Apparatus for oxygenating, centrifuging and changing the temperature of blood |
| US3489647A (en) | 1964-05-06 | 1970-01-13 | Dow Corning | Artificial organ for membrane dialysis of biological fluids |
| US3847211A (en) | 1969-01-28 | 1974-11-12 | Sub Marine Syst Inc | Property interchange system for fluids |
| US3738813A (en) | 1971-06-04 | 1973-06-12 | W Esmond | Mass transfer device and method of making same |
| GB1408562A (en) | 1971-07-26 | 1975-10-01 | Atomic Energy Authority Uk | Apparatus for use in dialysis |
| GB1442754A (en) * | 1972-06-28 | 1976-07-14 | Nat Res Dev | Apparatus for and method of effecting heat or mass transfer berween fluids |
| JPS5570149U (enExample) * | 1978-11-06 | 1980-05-14 | ||
| JPS573652A (en) | 1980-06-06 | 1982-01-09 | Kanegafuchi Chemical Ind | Artificial lung using minute hole diameter film |
| FR2504392A1 (fr) * | 1981-04-24 | 1982-10-29 | Hospal Sodip | Appareil a membrane avec supports a action decalee |
| US4620965A (en) | 1982-09-22 | 1986-11-04 | Terumo Corporation | Hollow fiber-type artificial lung |
| JPS6264372A (ja) | 1985-09-13 | 1987-03-23 | テルモ株式会社 | 膜型人工肺 |
| US4997565A (en) * | 1986-06-16 | 1991-03-05 | Niesen Lawrence J | Laboratory scale ultrafiltration apparatus |
| US4756835A (en) | 1986-08-29 | 1988-07-12 | Advanced Polymer Technology, Inc. | Permeable membranes having high flux-density and low fouling-propensity |
| GB8817793D0 (en) * | 1988-07-26 | 1988-09-01 | British Petroleum Co Plc | Mixing apparatus |
| DE69017032T2 (de) * | 1989-08-17 | 1995-07-20 | Brian John Bellhouse | Verfahren und vorrichtung zum bewirken eines wärme- und massetransfers durch eine membran mit hilfe von wirbeln. |
| US5207639A (en) | 1991-02-21 | 1993-05-04 | Cooper William I | Fetal lung apparatus |
| US6514412B1 (en) * | 1998-06-18 | 2003-02-04 | 3M Innovative Properties Company | Microstructured separation device |
| US6241945B1 (en) | 1998-03-16 | 2001-06-05 | Life Science Holdings, Inc. | Modular combined pump, filtration, oxygenation and/or debubbler apparatus |
| US7759113B2 (en) | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
| US7371400B2 (en) | 2001-01-02 | 2008-05-13 | The General Hospital Corporation | Multilayer device for tissue engineering |
| US6759008B1 (en) | 1999-09-30 | 2004-07-06 | Therox, Inc. | Apparatus and method for blood oxygenation |
| US7776021B2 (en) | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
| WO2002009647A2 (en) | 2000-07-28 | 2002-02-07 | Emory University | Biological component comprising artificial membrane |
| NL1017570C2 (nl) * | 2001-03-12 | 2002-09-13 | Stichting Hogeschool Van Utrec | Bloedbehandelingsinrichting. |
| DE10139830A1 (de) | 2001-08-14 | 2003-02-27 | Roche Diagnostics Gmbh | Strukturierte Membran |
| US20030175149A1 (en) | 2002-03-18 | 2003-09-18 | Bruce Searles | Renewable, modifiable, membrane gas exchanger |
| WO2004026115A2 (en) | 2002-09-23 | 2004-04-01 | The General Hospital Corporation | Theree-dimensional construct for the design and fabrication of physiological fluidic networks |
| US7955504B1 (en) | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
| JP2008515551A (ja) | 2004-10-06 | 2008-05-15 | ステイト オブ オレゴン アクティング バイ アンド スルー ザ ステイト ボード オブ ハイヤー エデュケーション オン ビハーフ オブ オレゴン ステイト ユニバーシティー | Ｍｅｃｓ透析器 |
| US8663625B2 (en) | 2004-10-15 | 2014-03-04 | Cornell Research Foundation | Diffusively permeable monolithic biomaterial with embedded microfluidic channels |
| US7794593B2 (en) | 2005-11-30 | 2010-09-14 | 3M Innovative Properties Company | Cross-flow membrane module |
| GB2437254B (en) * | 2006-04-13 | 2010-11-17 | Haemair Ltd | Blood/air mass exchange apparatus |
| WO2009039378A2 (en) | 2007-09-19 | 2009-03-26 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures for biomedical applications |
| US20090234332A1 (en) | 2008-03-17 | 2009-09-17 | The Charles Stark Draper Laboratory, Inc | Artificial microvascular device and methods for manufacturing and using the same |
| DE102008045621A1 (de) * | 2008-09-03 | 2010-03-04 | Novalung Gmbh | Gastransfervorrichtung und Verwendung einer strukturierten Membran |
| US8292492B2 (en) * | 2008-11-11 | 2012-10-23 | Sandia Corporation | Airfoil-shaped micro-mixers for reducing fouling on membrane surfaces |
| WO2011044116A2 (en) | 2009-10-05 | 2011-04-14 | The Charles Stark Draper Laboratory, Inc. | Three-dimensional microfluidic platforms and methods of use and manufacture thereof |
| WO2011082323A1 (en) * | 2009-12-31 | 2011-07-07 | The Charles Stark Draper Laboratory, Inc. | Microfluidic device facilitating gas exchange, and methods of use and manufacture thereof |
| JP2013534461A (ja) * | 2010-05-26 | 2013-09-05 | ザ チャールズ スターク ドレイパー ラボラトリー インク | 微細加工された人工肺補助装置ならびにその使用および製造の方法 |
| US9844779B2 (en) | 2011-01-14 | 2017-12-19 | The Charles Stark Draper Laboratory, Inc. | Membrane-integrated microfluidic device for imaging cells |
-
2012
- 2012-12-05 IN IN4342CHN2014 patent/IN2014CN04342A/en unknown
- 2012-12-05 EP EP12799501.7A patent/EP2788042B1/en active Active
- 2012-12-05 WO PCT/US2012/067971 patent/WO2013086011A1/en not_active Ceased
- 2012-12-05 ES ES12799501T patent/ES2700249T3/es active Active
- 2012-12-05 CN CN201280059591.9A patent/CN104053461A/zh active Pending
- 2012-12-05 US US13/705,795 patent/US9180239B2/en active Active
- 2012-12-05 CA CA2858080A patent/CA2858080C/en active Active
- 2012-12-05 JP JP2014546025A patent/JP6395608B2/ja active Active
- 2012-12-05 AU AU2012347922A patent/AU2012347922B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6395608B2 (ja) | 2018-09-26 |
| JP2015500699A (ja) | 2015-01-08 |
| EP2788042B1 (en) | 2018-10-31 |
| AU2012347922A1 (en) | 2014-06-12 |
| AU2012347922B2 (en) | 2017-12-21 |
| EP2788042A1 (en) | 2014-10-15 |
| US9180239B2 (en) | 2015-11-10 |
| WO2013086011A1 (en) | 2013-06-13 |
| ES2700249T3 (es) | 2019-02-14 |
| US20130144266A1 (en) | 2013-06-06 |
| CA2858080A1 (en) | 2013-06-13 |
| CN104053461A (zh) | 2014-09-17 |
| IN2014CN04342A (enExample) | 2015-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20171115 |