CN104053461A - 用于降低微流体肺辅助装置中的血液注入体积和膜表面积的方法 - Google Patents

用于降低微流体肺辅助装置中的血液注入体积和膜表面积的方法 Download PDF

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Publication number
CN104053461A
CN104053461A CN201280059591.9A CN201280059591A CN104053461A CN 104053461 A CN104053461 A CN 104053461A CN 201280059591 A CN201280059591 A CN 201280059591A CN 104053461 A CN104053461 A CN 104053461A
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China
Prior art keywords
flow channel
blood
oxygen
blood flow
microns
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Pending
Application number
CN201280059591.9A
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English (en)
Chinese (zh)
Inventor
杰弗里·T·伯恩斯坦
约瑟夫·L·查莱斯特
J·C·萧
T·克尼亚泽娃
E·金姆
A·埃普施特恩
V·科拉查拉马
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Charles Stark Draper Laboratory Inc
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Charles Stark Draper Laboratory Inc
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Publication of CN104053461A publication Critical patent/CN104053461A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698Blood oxygenators with or without heat-exchangers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/20Flow characteristics having means for promoting or enhancing the flow, actively or passively

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CN201280059591.9A 2011-12-05 2012-12-05 用于降低微流体肺辅助装置中的血液注入体积和膜表面积的方法 Pending CN104053461A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161567104P 2011-12-05 2011-12-05
US61/567,104 2011-12-05
PCT/US2012/067971 WO2013086011A1 (en) 2011-12-05 2012-12-05 Method for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices

Publications (1)

Publication Number Publication Date
CN104053461A true CN104053461A (zh) 2014-09-17

Family

ID=47352068

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280059591.9A Pending CN104053461A (zh) 2011-12-05 2012-12-05 用于降低微流体肺辅助装置中的血液注入体积和膜表面积的方法

Country Status (9)

Country Link
US (1) US9180239B2 (enExample)
EP (1) EP2788042B1 (enExample)
JP (1) JP6395608B2 (enExample)
CN (1) CN104053461A (enExample)
AU (1) AU2012347922B2 (enExample)
CA (1) CA2858080C (enExample)
ES (1) ES2700249T3 (enExample)
IN (1) IN2014CN04342A (enExample)
WO (1) WO2013086011A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116019995A (zh) * 2022-12-26 2023-04-28 清华大学 微流控人工肺及其制造方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
CN103180032A (zh) * 2010-05-26 2013-06-26 查尔斯斯塔克布料实验室公司 微制造的人造肺辅助装置及其使用和制造方法
CA2902061C (en) * 2013-02-28 2023-08-08 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
WO2015039118A1 (en) 2013-09-16 2015-03-19 Johnson & Johnson Innovation LLC Microfluidic organ assist device incorporating boundary layer disrupters
EP3134145B1 (en) 2014-04-23 2019-06-12 The Charles Stark Draper Laboratory, Inc. Blood oxygenator
WO2016060795A1 (en) * 2014-10-14 2016-04-21 Becton, Dickinson And Company Blood sample management using open cell foam
WO2016145210A1 (en) 2015-03-10 2016-09-15 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
IL285359B2 (en) 2015-04-23 2024-01-01 Hemanext Inc Anaerobic blood storage containers
PT3297641T (pt) 2015-05-18 2025-10-09 Hemanext Inc Métodos de armazenamento de sangue total e respetivas composições
US11673094B2 (en) 2016-05-27 2023-06-13 The Charles Stark Draper Laboratory, Inc. Biomimetic microfluidic device for high efficiency carbon dioxide removal from patients at low blood flow rates
CN109195632A (zh) 2016-05-27 2019-01-11 新健康科学股份有限公司 厌氧血液储存和病原体失活方法
US11988471B2 (en) * 2021-03-27 2024-05-21 Massachusetts Institute Of Technology Devices and methods for fabrication of components of a multiscale porous high-temperature heat exchanger

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076529A1 (en) * 2001-03-12 2002-10-03 Stichting Hogeschool Van Utrecht Blood processing device
US7955504B1 (en) * 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US20110158847A1 (en) * 2009-12-31 2011-06-30 Charest Joseph L Microfluidic Device Facilitating Gas Exchange, and Methods of Use and Manufacture Thereof
US20110226686A1 (en) * 2008-09-03 2011-09-22 Novalung Gmbh Gas transfer device and use of a structured membrane
WO2011150216A1 (en) * 2010-05-26 2011-12-01 The Charles Stark Draper Laboratory, Inc. Microfabricated artificial lung assist device, and methods of use and manufacture thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876769A (en) 1955-10-11 1959-03-10 Cordova Jose Juan Apparatus for oxygenating, centrifuging and changing the temperature of blood
US3489647A (en) 1964-05-06 1970-01-13 Dow Corning Artificial organ for membrane dialysis of biological fluids
US3847211A (en) 1969-01-28 1974-11-12 Sub Marine Syst Inc Property interchange system for fluids
US3738813A (en) 1971-06-04 1973-06-12 W Esmond Mass transfer device and method of making same
GB1408562A (en) 1971-07-26 1975-10-01 Atomic Energy Authority Uk Apparatus for use in dialysis
GB1442754A (en) * 1972-06-28 1976-07-14 Nat Res Dev Apparatus for and method of effecting heat or mass transfer berween fluids
JPS5570149U (enExample) * 1978-11-06 1980-05-14
JPS573652A (en) 1980-06-06 1982-01-09 Kanegafuchi Chemical Ind Artificial lung using minute hole diameter film
FR2504392A1 (fr) * 1981-04-24 1982-10-29 Hospal Sodip Appareil a membrane avec supports a action decalee
US4620965A (en) 1982-09-22 1986-11-04 Terumo Corporation Hollow fiber-type artificial lung
JPS6264372A (ja) 1985-09-13 1987-03-23 テルモ株式会社 膜型人工肺
US4997565A (en) * 1986-06-16 1991-03-05 Niesen Lawrence J Laboratory scale ultrafiltration apparatus
US4756835A (en) 1986-08-29 1988-07-12 Advanced Polymer Technology, Inc. Permeable membranes having high flux-density and low fouling-propensity
GB8817793D0 (en) * 1988-07-26 1988-09-01 British Petroleum Co Plc Mixing apparatus
ATE118357T1 (de) * 1989-08-17 1995-03-15 Brian John Bellhouse Verfahren und vorrichtung zum bewirken eines wärme- und massetransfers durch eine membran mit hilfe von wirbeln.
US5207639A (en) 1991-02-21 1993-05-04 Cooper William I Fetal lung apparatus
US6514412B1 (en) * 1998-06-18 2003-02-04 3M Innovative Properties Company Microstructured separation device
US6241945B1 (en) 1998-03-16 2001-06-05 Life Science Holdings, Inc. Modular combined pump, filtration, oxygenation and/or debubbler apparatus
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6759008B1 (en) 1999-09-30 2004-07-06 Therox, Inc. Apparatus and method for blood oxygenation
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US7713544B2 (en) 2000-07-28 2010-05-11 Emory University Biological component comprising artificial membrane
AU2002239810A1 (en) 2001-01-02 2002-07-16 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
DE10139830A1 (de) 2001-08-14 2003-02-27 Roche Diagnostics Gmbh Strukturierte Membran
US20030175149A1 (en) 2002-03-18 2003-09-18 Bruce Searles Renewable, modifiable, membrane gas exchanger
AU2003275140A1 (en) 2002-09-23 2004-04-08 Massachusetts Institute Of Technology Theree-dimensional construct for the design and fabrication of physiological fluidic networks
KR20070083967A (ko) 2004-10-06 2007-08-24 더 스테이트 오브 오레곤 액팅 바이 앤드 쓰루 더 스테이트 보드 오브 하이어 에쥬케이션 온 비해프 오브 오레곤 스테이트 유니버시티 Mecs 투석기
US8663625B2 (en) 2004-10-15 2014-03-04 Cornell Research Foundation Diffusively permeable monolithic biomaterial with embedded microfluidic channels
US7794593B2 (en) 2005-11-30 2010-09-14 3M Innovative Properties Company Cross-flow membrane module
GB2437254B (en) * 2006-04-13 2010-11-17 Haemair Ltd Blood/air mass exchange apparatus
ES2639183T3 (es) 2007-09-19 2017-10-25 The Charles Stark Draper Laboratory, Inc. Estructuras microfluídicas con sección transversal circular
US20090234332A1 (en) 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
US8292492B2 (en) * 2008-11-11 2012-10-23 Sandia Corporation Airfoil-shaped micro-mixers for reducing fouling on membrane surfaces
US20110186165A1 (en) 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US9844779B2 (en) 2011-01-14 2017-12-19 The Charles Stark Draper Laboratory, Inc. Membrane-integrated microfluidic device for imaging cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076529A1 (en) * 2001-03-12 2002-10-03 Stichting Hogeschool Van Utrecht Blood processing device
US7955504B1 (en) * 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US20110226686A1 (en) * 2008-09-03 2011-09-22 Novalung Gmbh Gas transfer device and use of a structured membrane
US20110158847A1 (en) * 2009-12-31 2011-06-30 Charest Joseph L Microfluidic Device Facilitating Gas Exchange, and Methods of Use and Manufacture Thereof
WO2011150216A1 (en) * 2010-05-26 2011-12-01 The Charles Stark Draper Laboratory, Inc. Microfabricated artificial lung assist device, and methods of use and manufacture thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116019995A (zh) * 2022-12-26 2023-04-28 清华大学 微流控人工肺及其制造方法
CN116019995B (zh) * 2022-12-26 2025-09-02 清华大学 微流控人工肺及其制造方法

Also Published As

Publication number Publication date
EP2788042A1 (en) 2014-10-15
JP2015500699A (ja) 2015-01-08
CA2858080C (en) 2020-12-01
IN2014CN04342A (enExample) 2015-09-04
JP6395608B2 (ja) 2018-09-26
WO2013086011A1 (en) 2013-06-13
ES2700249T3 (es) 2019-02-14
AU2012347922A1 (en) 2014-06-12
US20130144266A1 (en) 2013-06-06
US9180239B2 (en) 2015-11-10
AU2012347922B2 (en) 2017-12-21
CA2858080A1 (en) 2013-06-13
EP2788042B1 (en) 2018-10-31

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