CA2857046A1 - Antimicrobial compositions comprising dgla, 15-ohepa and/or 15-hetre and methods of use thereof - Google Patents
Antimicrobial compositions comprising dgla, 15-ohepa and/or 15-hetre and methods of use thereof Download PDFInfo
- Publication number
- CA2857046A1 CA2857046A1 CA2857046A CA2857046A CA2857046A1 CA 2857046 A1 CA2857046 A1 CA 2857046A1 CA 2857046 A CA2857046 A CA 2857046A CA 2857046 A CA2857046 A CA 2857046A CA 2857046 A1 CA2857046 A1 CA 2857046A1
- Authority
- CA
- Canada
- Prior art keywords
- hetre
- antimicrobial composition
- units
- dgla
- composition comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 296
- 238000000034 method Methods 0.000 title claims description 63
- 230000000845 anti-microbial effect Effects 0.000 title description 238
- IUKXMNDGTWTNTP-RHDCIPCHSA-N 15-HETrE Chemical compound CCCCCC(O)\C=C\C=C/C\C=C/CCCCCCC(O)=O IUKXMNDGTWTNTP-RHDCIPCHSA-N 0.000 title description 4
- IUKXMNDGTWTNTP-OAHXIXLCSA-N 15(S)-HETrE Chemical compound CCCCC[C@H](O)\C=C\C=C/C\C=C/CCCCCCC(O)=O IUKXMNDGTWTNTP-OAHXIXLCSA-N 0.000 claims abstract description 113
- 150000002148 esters Chemical class 0.000 claims abstract description 6
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- UCRLQOPRDMGYOA-DFTDUNEMSA-L zinc;(4r)-4-[[(2s)-2-[[(4r)-2-[(1s,2s)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2s,3s)-1-[[(3s,6r,9s,12r,15s,18r,21s)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2s)-butan-2-yl]-6-(carbox Chemical compound [Zn+2].C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 UCRLQOPRDMGYOA-DFTDUNEMSA-L 0.000 claims description 64
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US13/478,990 US20120264705A1 (en) | 2012-01-26 | 2012-05-23 | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
| US13/478,990 | 2012-05-23 | ||
| PCT/US2013/023201 WO2013112876A1 (en) | 2012-01-26 | 2013-01-25 | Antimicrobial compositions comprising dgla, 15-ohepa and/or 15-hetre and methods of use thereof |
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| US (2) | US20120264705A1 (enExample) |
| EP (1) | EP2806868A4 (enExample) |
| JP (3) | JP6557009B2 (enExample) |
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| CN (1) | CN104114166A (enExample) |
| AU (1) | AU2013211982A1 (enExample) |
| BR (1) | BR112014018421A8 (enExample) |
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| WO (1) | WO2013112876A1 (enExample) |
| ZA (1) | ZA201403948B (enExample) |
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| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| MX2014004710A (es) * | 2011-10-19 | 2014-12-10 | Dignity Sciences Ltd | Composiciones farmaceuticas que comprenden dgla y/o 15-hetre y metodos para usar los mismos. |
| US9855236B2 (en) | 2011-10-19 | 2018-01-02 | Ds Biopharma Limited | Pharmaceutical compositions comprising DGLA and/or 15-HETrE and methods of use thereof |
| GB201301626D0 (en) * | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| GB201307082D0 (en) * | 2013-04-19 | 2013-05-29 | Dignity Sciences Ltd | Pharmaceutical composition comprising 15-HETrE and methods of using the same |
| US20150080329A1 (en) * | 2013-09-19 | 2015-03-19 | Dignity Sciences Limited | Pharmaceutical compositions comprising dha, epa, and/or gla and an antibiotic agent and methods of use thereof |
| EP3068757B1 (en) | 2013-11-15 | 2019-02-27 | DS Biopharma Limited | Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid |
| MX2016008953A (es) * | 2014-01-10 | 2017-02-02 | Dignity Sciences Ltd | Composiciones farmaceuticas que comprenden i5-hidroxi-eicosa- 5,8,11,13,17-pentaenoico ( 15-hepe ) y metodos para tratar el asma y trastornos pulmonares que usan las mismas. |
| WO2015185698A1 (en) | 2014-06-04 | 2015-12-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla and use of same |
| LT6177B (lt) | 2014-10-10 | 2015-07-27 | Uab "Biocentras" | Fermentų kompleksų išskyrimas iš steptomyces gougerotii 101, daugiafermentinių biopreparatų ruošimas bei taikymas |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| JP2018502163A (ja) * | 2015-01-16 | 2018-01-25 | アフィミューン リミテッド | １５−ｈｅｐｅを含む組成物及びそれを使用する方法 |
| JP2018520197A (ja) | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| CN113230244A (zh) | 2015-12-18 | 2021-08-10 | 艾菲穆恩有限公司 | 包含15-hepe的组合物及其使用方法 |
| US20200206173A1 (en) | 2017-08-30 | 2020-07-02 | Conopco, Inc., D/B/A Unilever | A personal care composition |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
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| US4344930A (en) * | 1975-10-30 | 1982-08-17 | Colgate-Palmolive Company | Skin care sponge |
| JP4926310B2 (ja) * | 1996-02-15 | 2012-05-09 | エルテーベー４・スウェーデン・アクチェボラーグ | 抗ウイルス薬および抗腫瘍薬としてのロイコトリエンｂ４またはその類似体の使用 |
| US5789441A (en) * | 1996-02-15 | 1998-08-04 | Virocell Inc. | Leukotriene B4 as an antiviral and anti-neoplastic agent |
| US6190645B1 (en) * | 1999-07-15 | 2001-02-20 | Playtex Products, Inc. | Sunscreen for the scalp hair and hair |
| US20030073930A1 (en) * | 2001-10-17 | 2003-04-17 | Morrissey Gerald R. | Methods and device for preventing or healing injured nipples or areolas in mammalian females or for obtaining samples from nipples in mammalian females |
| US20030105445A1 (en) * | 2001-11-30 | 2003-06-05 | Kimberly-Clark Worldwide, Inc. | Breast pad assembly containing a skin benefit ingredient |
| US20050239889A1 (en) * | 2004-04-26 | 2005-10-27 | Jean Gosselin | In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration |
| JP2009522303A (ja) * | 2005-12-30 | 2009-06-11 | ウェイ−ウー ヒー， | 瘢痕を生じない皮膚創傷治癒を促進するｓｉＲＮＡ組成物および創傷処置の方法 |
| JP2010509930A (ja) * | 2006-11-23 | 2010-04-02 | カーギル インコーポレイテッド | 化工でんぷんの天然相当物 |
| EP2155251B1 (en) * | 2007-05-08 | 2013-09-25 | Rq Bioscience, Inc. | Therapeutic compositions and methods for treating gram-negative bacterial infections |
| EP2159732A1 (en) * | 2008-08-21 | 2010-03-03 | Thomson Licensing | Method and device for code obfuscation |
| GB0907413D0 (en) * | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| US8399226B2 (en) * | 2009-06-16 | 2013-03-19 | E I Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| US8293790B2 (en) * | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
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2013
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- 2013-01-25 SG SG11201404088TA patent/SG11201404088TA/en unknown
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- 2013-01-25 HK HK14112445.0A patent/HK1198921A1/xx unknown
- 2013-01-25 AU AU2013211982A patent/AU2013211982A1/en not_active Abandoned
- 2013-01-25 EP EP13741302.7A patent/EP2806868A4/en not_active Withdrawn
- 2013-01-25 KR KR1020147018192A patent/KR20140117379A/ko not_active Abandoned
- 2013-01-25 BR BR112014018421A patent/BR112014018421A8/pt not_active Application Discontinuation
- 2013-01-25 CA CA2857046A patent/CA2857046A1/en not_active Abandoned
- 2013-01-25 RU RU2014134720A patent/RU2014134720A/ru not_active Application Discontinuation
- 2013-01-25 MX MX2014006947A patent/MX2014006947A/es unknown
- 2013-01-25 WO PCT/US2013/023201 patent/WO2013112876A1/en not_active Ceased
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2014
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2017
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2019
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| JP2018065818A (ja) | 2018-04-26 |
| WO2013112876A1 (en) | 2013-08-01 |
| IL232777A0 (en) | 2014-07-31 |
| BR112014018421A8 (pt) | 2017-07-11 |
| EP2806868A1 (en) | 2014-12-03 |
| JP2020023513A (ja) | 2020-02-13 |
| JP6557009B2 (ja) | 2019-08-07 |
| RU2014134720A (ru) | 2016-03-20 |
| ZA201403948B (en) | 2015-12-23 |
| MX2014006947A (es) | 2015-03-05 |
| US20120264705A1 (en) | 2012-10-18 |
| PH12014501693A1 (en) | 2014-10-20 |
| SG11201404088TA (en) | 2014-10-30 |
| JP2015504921A (ja) | 2015-02-16 |
| EP2806868A4 (en) | 2015-08-26 |
| HK1198921A1 (en) | 2015-06-19 |
| CN104114166A (zh) | 2014-10-22 |
| BR112014018421A2 (enExample) | 2017-06-20 |
| AU2013211982A1 (en) | 2014-06-19 |
| US20140171358A1 (en) | 2014-06-19 |
| KR20140117379A (ko) | 2014-10-07 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20180124 |
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| FZDE | Discontinued |
Effective date: 20210224 |