CA2849577A1 - Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage - Google Patents
Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage Download PDFInfo
- Publication number
- CA2849577A1 CA2849577A1 CA2849577A CA2849577A CA2849577A1 CA 2849577 A1 CA2849577 A1 CA 2849577A1 CA 2849577 A CA2849577 A CA 2849577A CA 2849577 A CA2849577 A CA 2849577A CA 2849577 A1 CA2849577 A1 CA 2849577A1
- Authority
- CA
- Canada
- Prior art keywords
- exosomes
- antibodies
- ngal
- immunopurification
- urine sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/054187 WO2013041913A1 (en) | 2011-09-22 | 2011-09-22 | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2849577A1 true CA2849577A1 (en) | 2013-03-28 |
Family
ID=47913944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2849577A Abandoned CA2849577A1 (en) | 2011-09-22 | 2011-09-22 | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140329334A1 (https=) |
| EP (1) | EP2758774A4 (https=) |
| JP (1) | JP5893742B2 (https=) |
| KR (1) | KR20140076571A (https=) |
| CN (1) | CN103917869A (https=) |
| AU (1) | AU2011377379A1 (https=) |
| BR (1) | BR112014006741A2 (https=) |
| CA (1) | CA2849577A1 (https=) |
| HK (1) | HK1199754A1 (https=) |
| IL (1) | IL231626A0 (https=) |
| IN (1) | IN2014DN03194A (https=) |
| MX (1) | MX2014003422A (https=) |
| PH (1) | PH12014500650A1 (https=) |
| RU (1) | RU2014115999A (https=) |
| WO (1) | WO2013041913A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6297676B2 (ja) | 2013-05-06 | 2018-03-20 | 日立化成株式会社 | 標的分子を捕捉するためのデバイス及び方法 |
| FR3014198B1 (fr) * | 2013-12-03 | 2017-03-03 | Biomerieux Sa | Procede d'isolement d'exosomes |
| EP3169691B1 (en) * | 2014-07-17 | 2020-09-02 | The Trustees Of The University Of Pennsylvania | Methods for using exosomes to monitor transplanted organ status |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| US20170315134A1 (en) * | 2014-11-11 | 2017-11-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US10370719B2 (en) | 2014-11-12 | 2019-08-06 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016140388A1 (ko) * | 2015-03-05 | 2016-09-09 | 경북대학교 산학협력단 | 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법 |
| US20160320390A1 (en) * | 2015-05-01 | 2016-11-03 | Morehouse School Of Medicine | Compositions and methods for capturing exosomes |
| WO2017027858A1 (en) * | 2015-08-12 | 2017-02-16 | The Trustees Of Columbia University In The City Of New York | Methods of treating volume depletion and kidney injury |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| JP6531987B2 (ja) * | 2015-10-01 | 2019-06-19 | 国立大学法人名古屋大学 | 腎疾患診断のためのエクソソーム回収法 |
| CN105441578B (zh) * | 2016-01-19 | 2018-08-31 | 中南大学湘雅二医院 | 尿液外泌体microRNA分子标志物的应用及制备的试剂盒 |
| JP7064665B2 (ja) | 2016-03-07 | 2022-05-11 | ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル | 非侵襲的分子対照 |
| CN106053811A (zh) * | 2016-06-05 | 2016-10-26 | 浙江大学 | 一种尿液外泌体elisa的检测方法及其应用 |
| RU2647327C2 (ru) * | 2016-07-05 | 2018-03-15 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО КубГМУ Минздрава России) | Способ ранней диагностики хронической болезни почек у пациентов с хронической обструктивной болезнью легких |
| JP2019168223A (ja) * | 2016-08-12 | 2019-10-03 | 公立大学法人和歌山県立医科大学 | エクソソームの膜に存在するタンパク質の検出方法 |
| CN109425742A (zh) * | 2017-08-23 | 2019-03-05 | 迪亚莱博（张家港）生物科技有限公司 | 一种化学发光法快速检测水通道蛋白1的试剂盒 |
| JPWO2019045049A1 (ja) * | 2017-09-01 | 2020-12-03 | 学校法人帝京大学 | 腎尿細管細胞特異的発現ベクター |
| RU2702023C1 (ru) * | 2018-08-17 | 2019-10-04 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ диагностики острого повреждения почек после органосохраняющего хирургического лечения локализованного рака почки |
| ES2968898T3 (es) * | 2019-06-06 | 2024-05-14 | Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz | Método in vitro para detectar enfermedad renal |
| EP3904883A1 (en) * | 2020-04-07 | 2021-11-03 | Sciomics GmbH | Prediction and early diagnosis of acute kidney injury |
| RU2765678C1 (ru) * | 2020-12-21 | 2022-02-01 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом |
| CN113189321B (zh) * | 2021-04-12 | 2024-06-25 | 攸太科技(台州)有限公司 | 一种尿液检测方法 |
| WO2024085722A1 (ko) * | 2022-10-20 | 2024-04-25 | 건국대학교 산학협력단 | 신장 질환의 조기 진단을 위한 바이오마커 조성물 및 이를 이용한 신장 질환의 조기 진단에 필요한 정보를 제공하는 방법 |
| KR20250003155A (ko) * | 2023-06-30 | 2025-01-07 | 연세대학교 산학협력단 | 급성신손상의 회복에 대한 정보 제공 방법 및 이를 이용한 키트 |
| CN116883739B (zh) * | 2023-07-10 | 2026-04-10 | 中国医学科学院生物医学工程研究所 | 一种基于图像识别的尿隐血分类方法和系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US20040241176A1 (en) * | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| WO2004013152A2 (en) * | 2002-08-06 | 2004-02-12 | Duke University | Novel targets for lithium therapy |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| US8758991B2 (en) * | 2006-04-26 | 2014-06-24 | University Of Louisville Research Foundation, Inc. | Isolation of membrane vesicles from biological fluids and methods of using same |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| US20110124519A1 (en) * | 2008-03-18 | 2011-05-26 | Frank Walter Falkenberg | Method of assessing kidney function in a human subject |
| CA2742291A1 (en) * | 2008-11-05 | 2010-05-14 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, andmethods of enrichment, analysis and use |
| GB2463401B (en) * | 2008-11-12 | 2014-01-29 | Caris Life Sciences Luxembourg Holdings S A R L | Characterizing prostate disorders by analysis of microvesicles |
| CN102292637B (zh) * | 2008-11-21 | 2015-08-05 | 法蒂亚公司 | 用于检测或监测急性肾损伤的方法、装置和试剂盒 |
| GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
| EP2433137B1 (en) * | 2009-05-18 | 2015-07-29 | Washington University | Methods of renal cancer detection |
-
2011
- 2011-09-22 US US14/346,679 patent/US20140329334A1/en not_active Abandoned
- 2011-09-22 BR BR112014006741A patent/BR112014006741A2/pt not_active IP Right Cessation
- 2011-09-22 KR KR1020147009382A patent/KR20140076571A/ko not_active Withdrawn
- 2011-09-22 HK HK15100094.8A patent/HK1199754A1/xx unknown
- 2011-09-22 EP EP20110872834 patent/EP2758774A4/en not_active Withdrawn
- 2011-09-22 WO PCT/IB2011/054187 patent/WO2013041913A1/en not_active Ceased
- 2011-09-22 CN CN201180074742.3A patent/CN103917869A/zh active Pending
- 2011-09-22 RU RU2014115999/15A patent/RU2014115999A/ru unknown
- 2011-09-22 CA CA2849577A patent/CA2849577A1/en not_active Abandoned
- 2011-09-22 AU AU2011377379A patent/AU2011377379A1/en not_active Abandoned
- 2011-09-22 PH PH1/2014/500650A patent/PH12014500650A1/en unknown
- 2011-09-22 MX MX2014003422A patent/MX2014003422A/es not_active Application Discontinuation
- 2011-09-22 JP JP2014531321A patent/JP5893742B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-20 IL IL231626A patent/IL231626A0/en unknown
- 2014-04-22 IN IN3194DEN2014 patent/IN2014DN03194A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014DN03194A (https=) | 2015-05-22 |
| HK1199754A1 (en) | 2015-07-17 |
| EP2758774A1 (en) | 2014-07-30 |
| MX2014003422A (es) | 2014-10-13 |
| BR112014006741A2 (pt) | 2017-03-28 |
| US20140329334A1 (en) | 2014-11-06 |
| WO2013041913A1 (en) | 2013-03-28 |
| EP2758774A4 (en) | 2015-04-29 |
| IL231626A0 (en) | 2014-05-28 |
| KR20140076571A (ko) | 2014-06-20 |
| PH12014500650A1 (en) | 2014-06-02 |
| RU2014115999A (ru) | 2015-10-27 |
| AU2011377379A1 (en) | 2014-04-10 |
| CN103917869A (zh) | 2014-07-09 |
| JP5893742B2 (ja) | 2016-03-23 |
| JP2014528076A (ja) | 2014-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170922 |