CA2847328A1 - Oral formulations containing hyaluronic acid for sustained drug release - Google Patents
Oral formulations containing hyaluronic acid for sustained drug release Download PDFInfo
- Publication number
- CA2847328A1 CA2847328A1 CA2847328A CA2847328A CA2847328A1 CA 2847328 A1 CA2847328 A1 CA 2847328A1 CA 2847328 A CA2847328 A CA 2847328A CA 2847328 A CA2847328 A CA 2847328A CA 2847328 A1 CA2847328 A1 CA 2847328A1
- Authority
- CA
- Canada
- Prior art keywords
- tablet
- capsule
- hyaluronic acid
- salt
- hyaluronate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960001027 opium Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229930015710 phenanthrene alkaloid Natural products 0.000 description 1
- 125000001792 phenanthrenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 238000009475 tablet pressing Methods 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11179819.5 | 2011-09-02 | ||
| EP11179819 | 2011-09-02 | ||
| PCT/EP2012/066975 WO2013030348A1 (en) | 2011-09-02 | 2012-08-31 | Oral formulations containing hyaluronic acid for sustained drug release |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2847328A1 true CA2847328A1 (en) | 2013-03-07 |
Family
ID=46755026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2847328A Abandoned CA2847328A1 (en) | 2011-09-02 | 2012-08-31 | Oral formulations containing hyaluronic acid for sustained drug release |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20140302131A1 (enExample) |
| EP (1) | EP2750665A1 (enExample) |
| KR (1) | KR20140058581A (enExample) |
| CN (1) | CN103781473A (enExample) |
| AU (1) | AU2012300815A1 (enExample) |
| CA (1) | CA2847328A1 (enExample) |
| IL (1) | IL230787A0 (enExample) |
| IN (1) | IN2014CN02343A (enExample) |
| WO (1) | WO2013030348A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114767649A (zh) * | 2021-12-22 | 2022-07-22 | 北京佗林医药科技有限公司 | 一种顺式透明质酸六糖的制剂及其制备方法 |
| EP4487834A1 (en) | 2023-07-07 | 2025-01-08 | NuPep AS | Consensus peptides in hya |
| EP4487863A1 (en) | 2023-07-07 | 2025-01-08 | NuPep AS | Consensus peptides in hya for use in treating degenerated joints |
| EP4739277A1 (en) | 2023-07-07 | 2026-05-13 | NuPep AS | Consensus peptides in hya |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60251898A (ja) | 1984-05-25 | 1985-12-12 | Shiseido Co Ltd | 醗酵法によるヒアルロン酸の製造方法 |
| IT1271001B (it) | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| WO1997028828A1 (en) | 1996-02-09 | 1997-08-14 | Amgen Boulder Inc. | Composition comprising interleukin-1 inhibitor and controlled release polymer |
| DK0941349T3 (da) | 1996-11-18 | 2004-02-09 | Novozymes Biotech Inc | Fremgangsmåde til fremstilling af polypeptider i surfactinmutanter af Bacillusceller |
| JP4234803B2 (ja) * | 1997-10-27 | 2009-03-04 | 久光製薬株式会社 | 薬物放出速度が制御された医薬組成物 |
| ATE284954T1 (de) | 1997-10-31 | 2005-01-15 | Univ Oklahoma | Hyaluronan synthase gen und seine verwendung |
| CA2326821C (en) | 1998-04-02 | 2010-09-28 | The Board Of Regents Of The University Of Oklahoma | Nucleic acid encoding hyaluronan synthase and methods of use |
| US6444447B1 (en) | 1998-11-11 | 2002-09-03 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| JP2005525091A (ja) | 2001-12-21 | 2005-08-25 | ノボザイムス バイオポリマー アクティーゼルスカブ | 組換え宿主細胞におけるヒアルロナンの生成方法 |
| WO2003061626A1 (en) | 2002-01-18 | 2003-07-31 | Control Delivery Systems, Inc. | Polymeric gel system for the controlled delivery of codrugs |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
-
2012
- 2012-08-31 WO PCT/EP2012/066975 patent/WO2013030348A1/en not_active Ceased
- 2012-08-31 AU AU2012300815A patent/AU2012300815A1/en not_active Abandoned
- 2012-08-31 EP EP12751545.0A patent/EP2750665A1/en not_active Withdrawn
- 2012-08-31 KR KR1020147005084A patent/KR20140058581A/ko not_active Withdrawn
- 2012-08-31 CA CA2847328A patent/CA2847328A1/en not_active Abandoned
- 2012-08-31 US US14/342,486 patent/US20140302131A1/en not_active Abandoned
- 2012-08-31 CN CN201280042014.9A patent/CN103781473A/zh active Pending
- 2012-08-31 IN IN2343CHN2014 patent/IN2014CN02343A/en unknown
-
2014
- 2014-02-03 IL IL230787A patent/IL230787A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140058581A (ko) | 2014-05-14 |
| CN103781473A (zh) | 2014-05-07 |
| EP2750665A1 (en) | 2014-07-09 |
| IL230787A0 (en) | 2014-03-31 |
| AU2012300815A1 (en) | 2014-02-20 |
| US20140302131A1 (en) | 2014-10-09 |
| WO2013030348A1 (en) | 2013-03-07 |
| IN2014CN02343A (enExample) | 2015-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170831 |