CA2846218C - Cell-penetrating peptides having a central hydrophobic domain - Google Patents
Cell-penetrating peptides having a central hydrophobic domain Download PDFInfo
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- CA2846218C CA2846218C CA2846218A CA2846218A CA2846218C CA 2846218 C CA2846218 C CA 2846218C CA 2846218 A CA2846218 A CA 2846218A CA 2846218 A CA2846218 A CA 2846218A CA 2846218 C CA2846218 C CA 2846218C
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
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| US201161528804P | 2011-08-30 | 2011-08-30 | |
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| GBGB1115014.1A GB201115014D0 (en) | 2011-08-30 | 2011-08-30 | Peptides |
| GBGB1211740.4A GB201211740D0 (en) | 2012-07-03 | 2012-07-03 | Peptides |
| GB1211740.4 | 2012-07-03 | ||
| PCT/GB2012/052116 WO2013030569A2 (en) | 2011-08-30 | 2012-08-29 | Peptides |
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| JP (1) | JP6077543B2 (OSRAM) |
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| ES (1) | ES2876939T3 (OSRAM) |
| IN (1) | IN2014MN00357A (OSRAM) |
| WO (1) | WO2013030569A2 (OSRAM) |
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| EP3094379A4 (en) | 2014-01-13 | 2017-06-28 | Berg LLC | Enolase 1 (eno1) compositions and uses thereof |
| EP3151848A4 (en) * | 2014-06-06 | 2018-01-24 | Vivoscript, Inc. | Methods for repairing cartilage damage |
| CN111388680B (zh) * | 2015-01-28 | 2024-01-05 | 中国科学院天津工业生物技术研究所 | 一种多肽复合物作为多肽或蛋白质药物载体的应用、方法及其融合蛋白复合物 |
| GB2545898B (en) * | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| EP4085920A1 (en) * | 2016-01-06 | 2022-11-09 | Stealth BioTherapeutics Inc. | Methods for the treatment of duchenne muscular dystrophy |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| KR102329187B1 (ko) | 2016-04-29 | 2021-11-22 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 인간 lmna를 표적화하는 올리고뉴클레오타이드 유사체 |
| SMT202200173T1 (it) | 2016-06-01 | 2022-05-12 | Athira Pharma Inc | Composti |
| AU2017291960B2 (en) | 2016-07-05 | 2024-03-14 | Biomarin Technologies B.V. | Pre-mRNA splice switching or modulating oligonucleotides comprising bicyclic scaffold moieties, with improved characteristics for the treatment of genetic disorders |
| SG11201906200WA (en) | 2017-01-06 | 2019-08-27 | Avidity Biosciences Llc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| WO2018150196A1 (en) * | 2017-02-17 | 2018-08-23 | Oxford University Innovation Limited | Cell penetrating peptides modified by glycosylation |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Ｎｒｆ２路徑的新穎化合物 |
| WO2019070962A1 (en) * | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | BICYCLIC PEPTIDE INHIBITORS |
| CN108070025B (zh) * | 2017-10-24 | 2019-11-19 | 中山大学附属口腔医院 | 一种细胞穿透肽和细胞穿透肽复合物及二者的应用 |
| WO2019148195A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of cal-pdz binding domain |
| JP2021521794A (ja) * | 2018-04-26 | 2021-08-30 | サレプタ セラピューティクス， インコーポレイテッド | 筋ジストロフィーに対するエクソンスキッピングオリゴマーおよびオリゴマーコンジュゲート |
| US11559586B2 (en) * | 2018-05-22 | 2023-01-24 | Children's Medical Center Corporation | Nanoparticles for treatment of choroidal neovascularization and other indications |
| GB201812980D0 (en) * | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| GB201812972D0 (en) * | 2018-08-09 | 2018-09-26 | Univ Oxford Innovation Ltd | Cell-penetrating peptides |
| BR112021010982A2 (pt) | 2018-12-07 | 2021-08-31 | Oxford University Innovation Limited | Ligantes |
| JP7481694B2 (ja) * | 2019-01-30 | 2024-05-13 | 国立研究開発法人国立精神・神経医療研究センター | 核酸送達複合体 |
| GB201911403D0 (en) * | 2019-08-09 | 2019-09-25 | Univ Oxford Innovation Ltd | Conjugate and uses thereof |
| IL310185A (en) | 2021-07-16 | 2024-03-01 | Academisch Ziekenhuis Leiden | Oligonucleotide for inhibiting quaking activity |
| EP4389893A4 (en) | 2021-08-21 | 2025-09-10 | Takeda Pharmaceuticals Co | PEPTIDE-DRUG CONJUGATE BINDING HUMAN TRANSFERRIN RECEPTOR |
| AU2023265171A1 (en) | 2022-05-06 | 2024-11-07 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Oligonucleotide |
| GB202216207D0 (en) * | 2022-11-01 | 2022-12-14 | Univ Oxford Innovation Ltd | Shortened cell-penetrating peptides |
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| CZ20011671A3 (cs) | 1998-11-13 | 2001-10-17 | Cyclacel Limited | Peptidová nosná skupina pro transport |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| AU2008271050B2 (en) | 2007-06-29 | 2014-11-06 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20110130346A1 (en) | 2008-05-30 | 2011-06-02 | Isis Innovation Limited | Peptide conjugates for delvery of biologically active compounds |
| EP2283029A1 (en) * | 2008-06-04 | 2011-02-16 | Medical Research Council | Peptides |
| US20120309684A1 (en) | 2009-11-30 | 2012-12-06 | Isis Innovation Limited | Conjugates for delivery of biologically active compounds |
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| US20140342992A1 (en) | 2014-11-20 |
| WO2013030569A3 (en) | 2013-06-13 |
| AU2012300633B2 (en) | 2017-04-27 |
| CN103998458A (zh) | 2014-08-20 |
| EP2751128A2 (en) | 2014-07-09 |
| AU2012300633A1 (en) | 2014-03-06 |
| JP2014526238A (ja) | 2014-10-06 |
| ES2876939T3 (es) | 2021-11-15 |
| US9302014B2 (en) | 2016-04-05 |
| EP2751128B1 (en) | 2021-03-03 |
| IN2014MN00357A (OSRAM) | 2015-06-19 |
| CA2846218A1 (en) | 2013-03-07 |
| WO2013030569A2 (en) | 2013-03-07 |
| AU2012300633A8 (en) | 2014-05-29 |
| BR112014004902B1 (pt) | 2022-02-08 |
| BR112014004902A2 (pt) | 2017-07-04 |
| CN103998458B (zh) | 2018-10-09 |
| JP6077543B2 (ja) | 2017-02-08 |
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